Nanobodies to Study G Protein-Coupled Receptor Structure and Function.
Annual Review of Pharmacology and Toxicology, 2017 Ligand-induced activation of G protein-coupled receptors (GPCRs) is a key mechanism permitting communication between cells and organs. Enormous progress has recently elucidated the structural and dynamic features of GPCR transmembrane signaling ...
A. Manglik, B. Kobilka, J. Steyaert
semanticscholar +1 more source
Regulators of G protein signalling proteins in the human myometrium [PDF]
, 2009 The contractile state of the human myometrium is controlled by extracellular signals that promote relaxation or contraction. Many of these signals function through G proteincoupled receptors at the cell surface, stimulating heterotrimeric G proteins and ...
Abramow-Newerly +52 more
core +1 more source
Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance
Molecular Oncology, EarlyView.In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang +8 more
wiley +1 more source
Frontiers in Endocrinology, 2018 Gonadotropin-releasing hormone (GnRH) neurons originate outside the central nervous system (CNS) in the nasal placode where their migration to the basal forebrain is dependent on the integration of multiple signaling cues during development.
Darwin O. Larco +5 more
doaj +1 more source
G protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling hub
Cellular and Molecular Life Sciences, 2019 Accumulating evidence indicates that G protein-coupled receptor kinase 2 (GRK2) is a versatile protein that acts as a signaling hub by modulating G protein-coupled receptor (GPCR) signaling and also via phosphorylation or scaffolding interactions with an
P. Penela +3 more
semanticscholar +1 more source
GAP-43 augments G protein-coupled receptor transduction in Xenopus laevis oocytes. [PDF]
, 1993 Stephen M. Strittmatter +4 more
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Theory for the optimal detection of time-varying signals in cellular sensing systems [PDF]
arXiv, 2019 Living cells often need to measure chemical concentrations that vary in time. To this end, they deploy many resources, e.g. receptors, downstream signaling molecules, time and energy. Here, we present a theory for the optimal design of a large class of sensing systems that need to detect time-varying signals, a receptor driving a push-pull network. The
arxiv
Molecular Oncology, EarlyView.This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou +13 more
wiley +1 more source
Mutation of a highly conserved acidic residue present in the second intracellular loop of G-protein-coupled receptors does not impair hormone binding or signal transduction of the luteinizing hormone/chorionic gonadotropin receptor. [PDF]
, 1993 Z Wang, H Wang, Mario Ascoli
openalex +1 more source
Moving Signals and Their Measured Frequencies [PDF]
arXiv, 2012 Classical Doppler Effect of light propagation can be calculated by making any one of the two assumptions a) Light propagates at the speed c with respect to the source or b) Light propagates at the speed c with respect to the receptor. We show that the ratio of the two calculated classical Doppler Effects, with propagation speed c in the source inertial
arxiv