Results 161 to 170 of about 728,478 (309)

The Diverse Roles of Arrestin Scaffolds in G Protein–Coupled Receptor Signaling

Pharmacological Reviews, 2017
Y. Peterson, L. Luttrell
semanticscholar   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling. [PDF]

Elife
Biswas K, Moore C, Rogers H, Wani KA, Mushtaq A, Pukkila-Worley R, Higgins DP, Walker AK, Mullen GP, Rand JB, Francis MM.   +10 more
europepmc   +1 more source

G Protein-Coupled Receptor Allosterism and Complexing

Pharmacological Reviews, 2002
A. Christopoulos, T. Kenakin
semanticscholar   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

A heteromeric TRP channel that functions as a WNT-activated G protein-coupled receptor. [PDF]

Nat Commun
Hardy EP, Haider AN, Patel MM, Nesin V, Hoang HTM, Gostynska SE, Berry WL, Pioszak AA, Ahmad M, Parnell SC, Tsiokas L.   +10 more
europepmc   +1 more source

Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents.

Cell Metabolism, 2006
H. Overton, A. J. Babbs, S. Doel, M. Fyfe, Lisa S Gardner, Graeme Griffin, H. Jackson, M. J. Procter, C. Rasamison, Mads Tang-Christensen, P. Widdowson, G. Williams, C. Reynet   +12 more
semanticscholar   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

A Novel Anti-Fibrotic Role of G-Protein-Coupled Receptor 119 in Hepatic Stellate Cells. [PDF]

Biomol Ther (Seoul)
Park J, Lee MH, Kim HY, Kim HS, Kim SK, Yang JW, Kang KW.   +6 more
europepmc   +1 more source