Results 211 to 220 of about 1,031,574 (396)

Characterization of the GTPγS release function of a G protein-coupled receptor. [PDF]

Nat Commun
Bohn LM, Stahl EL.
europepmc   +1 more source

Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.

Journal of Clinical Investigation, 2000
Yujing Liu, R. Wada, T. Yamashita, Yide Mi, C. Deng, J. P. Hobson, Hans M. Rosenfeldt, V. Nava, Sung-suk Chae, M. Lee, Catherine H. Liu, T. Hla, S. Spiegel, R. Proia   +13 more
semanticscholar   +1 more source

Towards deorphanizing G protein-coupled receptors of Schistosoma mansoni using the MALAR yeast two-hybrid system [PDF]

, 2019
Oliver Weth, Simone Haeberlein, Martin Haimann, Yinjie Zhang, Christoph G. Grevelding   +4 more
openalex   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Structure-function of the G protein-coupled receptor superfamily.

Annual Review of Pharmacology and Toxicology, 2013
V. Katritch, V. Cherezov, R. Stevens
semanticscholar   +1 more source

Mining of assembled expressed sequence tag (EST) data for protein families: Application to the G protein-coupled receptor superfamily [PDF]

, 2000
Darrell Conklin
openalex   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

G-protein-coupled receptor diversity and evolution in the closest living relatives of metazoa. [PDF]

Elife
Garcia De Las Bayonas A, King N.
europepmc   +1 more source

Structure of a β1-adrenergic G-protein-coupled receptor

Nature, 2008
Tony Warne, M. Serrano-Vega, J. Baker, R. Moukhametzianov, P. Edwards, R. Henderson, A. Leslie, C. Tate, G. Schertler   +8 more
semanticscholar   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source