Results 231 to 240 of about 830,364 (264)
Some of the next articles are maybe not open access.
G protein—coupled receptor kinases
Cell, 1993G protein‐coupled receptor kinases (GRKs) constitute a family of six mammalian serine/threonine protein kinases that phosphorylate agonist-bound, or activated, G protein‐coupled receptors (GPCRs) as their primary substrates. GRK-mediated receptor phosphorylation rapidly initiates profound impairment of receptor signaling, or desensitization.
openaire +2 more sources
Yeast Assays for G-Protein-Coupled Receptors
Receptors and Channels, 2002The functional coupling of heterologous G protein-coupled receptors (GPCRs) to the pheromone-response pathway of the budding yeast Saccharomyces cerevisiae is well established as an experimental system for ligand identification and for characterizing receptor pharmacology and signal transduction mechanisms.
S J, Dowell, A J, Brown
openaire +3 more sources
Oligomerisation of G-protein-coupled receptors
Journal of Cell Science, 2001ABSTRACT A range of approaches have recently provided evidence that G-protein-coupled receptors can exist as oligomeric complexes. Both homo-oligomers, comprising multiple copies of the same gene product, and hetero-oligomers containing more than one receptor have been detected.
openaire +2 more sources
G‐Protein–Coupled Receptor Deorphanizations
2005G protein–coupled receptors (GPCRs) are major regulators of intercellular interactions. They initiate these actions by being activated by a wide variety of natural ligands. Historically, ligands were discovered first, but the advent of molecular biology reversed this trend.
Yumiko, Saito, Olivier, Civelli
openaire +2 more sources
Ubiquitination of G-Protein-Coupled Receptors
2004In this chapter we describe methods for detecting the ubiquitination state of G-protein-coupled receptors (GPCRs). This involves coexpression of a GPCR with an epitope-tagged ubiquitin construct in a heterologous expression system. Modification by ubiquitin of the GPCR resulting from agonist activation is detected by immunoprecipation and subsequent ...
Adriano, Marchese, Jeffrey L, Benovic
openaire +2 more sources
Adrenergic Receptors As Models For G Protein-Coupled Receptors
Annual Review of Neuroscience, 1992Approximately 80% of known hormones and neurotransmitters activate cellular signal transduction mechanisms by activating G protein-coupled receptors (Birnbaumer et al 1990). Studying the structure and function of these receptors has been challenging because they are not naturally abun dant proteins and they require a lipid environment to be fully ...
openaire +2 more sources
Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-Vornhagen +2 more
exaly