Results 371 to 380 of about 1,156,973 (433)
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Crystal structure of rhodopsin: A G protein-coupled receptor.
Science, 2000Heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) respond to a variety of different external stimuli and activate G proteins.
K. Palczewski +11 more
semanticscholar +1 more source
Current Biology, 1992
The diversity of the G protein-coupled receptor superfamily is now being realised with the molecular cloning of DNA encoding many new receptors and receptor subfamilies. The existing pharmacological definitions of receptor subtypes have been extended dramatically with identification of additional subtypes at the molecular level.
John Shine, Tiina P. Iismaa
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The diversity of the G protein-coupled receptor superfamily is now being realised with the molecular cloning of DNA encoding many new receptors and receptor subfamilies. The existing pharmacological definitions of receptor subtypes have been extended dramatically with identification of additional subtypes at the molecular level.
John Shine, Tiina P. Iismaa
openaire +3 more sources
Pharmacogenetics of the G Protein-Coupled Receptors
2014Pharmacogenetics investigates the influence of genetic variants on physiological phenotypes related to drug response and disease, while pharmacogenomics takes a genome-wide approach to advancing this knowledge. Both play an important role in identifying responders and nonresponders to medication, avoiding adverse drug reactions, and optimizing drug ...
M. D. Thompson +6 more
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G Protein-Coupled Receptor Pharmacogenetics [PDF]
, 2008 Common G protein-coupled receptor (GPCR) gene variants that encode receptor proteins with a distinct sequence may alter drug efficacy without always resulting in a disease phenotype. GPCR genetic loci harbor numerous variants, such as DNA insertions or deletions and single-nucleotide polymorphisms that alter GPCR expression and function, thereby ...
Katherine A. Siminovitch +2 more
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G-protein-coupled receptors and cancer [PDF]
Nature Reviews Cancer, 2007 G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved in signal transmission, have recently emerged as crucial players in tumour growth and metastasis. Malignant cells often hijack the normal physiological functions of GPCRs to survive, proliferate autonomously, evade the immune system, increase their blood supply ...
Robert T. Dorsam, J. Silvio Gutkind
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G protein-coupled receptors in rheumatology
Nature Reviews Rheumatology, 2014G protein-coupled receptors (GPCRs) are transmembrane receptor proteins that allow the transfer of signals across the cell membrane. In addition to their physiological role, GPCRs are involved in many pathophysiological processes including pathways relevant in rheumatoid arthritis (RA), osteoarthritis (OA) and psoriatic arthritis.
Elena Neumann +2 more
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The role of receptor kinases and arrestins in G protein-coupled receptor regulation.
Annual Review of Pharmacology and Toxicology, 1998G protein-coupled receptors (GPRs) play a key role in controlling hormonal regulation of numerous second-messenger pathways. However, following agonist activation, most GPRs rapidly lose their ability to respond to hormone.
J. Krupnick, J. Benovic
semanticscholar +1 more source
2012
G protein coupled receptors play an important role due to physiological and pathophysiological processes and are responsible for signal transduction in the cell. Furthermore, about 30 % of drugs, present on market, address G protein coupled receptors. First, the families for classification of G protein coupled receptors are presented.
Andrea Strasser, Hans-Joachim Wittmann
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G protein coupled receptors play an important role due to physiological and pathophysiological processes and are responsible for signal transduction in the cell. Furthermore, about 30 % of drugs, present on market, address G protein coupled receptors. First, the families for classification of G protein coupled receptors are presented.
Andrea Strasser, Hans-Joachim Wittmann
openaire +2 more sources
Dimerization of G-Protein-Coupled Receptors
Journal of Medicinal Chemistry, 2001The evolutionary trace (ET) method, a data mining approach for determining significant levels of amino acid conservation, has been applied to over 700 aligned G-protein-coupled receptor (GPCR) sequences. The method predicted the occurrence of functionally important clusters of residues on the external faces of helices 5 and 6 for each family or ...
Christopher Higgs +8 more
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G-Protein-Coupled Receptor Microarrays
ChemBioChem, 2002Membrane-bound proteins represent the single most important class of drug targets. Arraying these proteins is difficult because they typically need to be embedded in membranes to maintain their correctly folded conformations. We describe here the fabrication of microarrays consisting of G-protein-coupled receptors (GPCRs)--the single largest family of ...
Anthony G. Frutos +2 more
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