Results 31 to 40 of about 728,478 (309)
Diabetes, 2012 Interest in how the gut microbiome can influence the metabolic state of the host has recently heightened. One postulated link is bacterial fermentation of “indigestible” prebiotics to short-chain fatty acids (SCFAs), which in turn modulate the release of
G. Tolhurst +9 more
semanticscholar +1 more source
Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor
Science, 2020 Choosing the drug to fit the protein Many approved drugs bind to G protein–coupled receptors (GPCRs). A challenge in targeting GPCRs is that different ligands preferentially activate different signaling pathways.
Carl-Mikael Suomivuori +10 more
semanticscholar +1 more source
Crystallization of G Protein-Coupled Receptors [PDF]
, 2013 Oligomerization is one of several mechanisms that can regulate the activity of G protein-coupled receptors (GPCRs), but little is known about the structure of GPCR oligomers. Crystallography and NMR are the only methods able to reveal the details of receptor-receptor interactions at an atomic level, and several GPCR homodimers already have been ...
David, Salom +2 more
openaire +2 more sources
Targeting G protein-coupled receptor for pain management
Brain Circulation, 2017 Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage. Great progress has been made in understanding the important roles of various G protein-coupled receptors in the
Hongyan Li +4 more
doaj +1 more source
The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids*
Journal of Biological Chemistry, 2003 GPR40 is a member of a subfamily of homologous G protein-coupled receptors that include GPR41 and GPR43 and that have no current function or ligand ascribed.
C. Briscoe +20 more
semanticscholar +1 more source
High capacity in G protein-coupled receptor signaling
Nature Communications, 2018 G protein-coupled receptors (GPCRs) activate intracellular signalling pathways upon extracellular stimulation. Here authors record single cell responses of GPCR signalling which allows the direct estimation of its channel capacity for each cell along ...
Amiran Keshelava +6 more
doaj +1 more source
AXOR12, a Novel Human G Protein-coupled Receptor, Activated by the Peptide KiSS-1*
Journal of Biological Chemistry, 2001 A novel human G protein-coupled receptor named AXOR12, exhibiting 81% homology to the rat orphan receptor GPR54, was cloned from a human brain cDNA library.
A. Muir +21 more
semanticscholar +1 more source
G-protein-coupled receptor kinases
Kidney International, 1996 beta-Adrenergic receptors are prototypes of the many G-protein-coupled receptors. Activation and inactivation of these receptors are regulated by multiple mechanisms which can affect either their function or their expression. The most obvious changes of such receptor systems are induced by activation of the receptors themselves by their respective ...
Lohse, Martin J. +3 more
openaire +2 more sources
Powdered G-Protein-Coupled Receptors [PDF]
The Journal of Physical Chemistry Letters, 2016 Preparation and storage of functional membrane proteins such as G-protein-coupled receptors (GPCRs) are crucial to the processes of drug delivery and discovery. Here, we describe a method of preparing powdered GPCRs using rhodopsin as the prototype. We purified rhodopsin in CHAPS detergent with low detergent to protein ratio so the bulk of the sample ...
Suchithranga M D C, Perera +2 more
openaire +2 more sources
Fluorescent leukotriene B4: potential applications
Journal of Lipid Research, 2005 Leukotriene B4 (LTB4) is a potent lipid mediator of inflammation that acts primarily via a seven-transmembrane-spanning, G-protein-coupled receptor denoted BLT1. Here, we describe the synthesis and characterization of fluorescent analogs of LTB4 that are
Alan Sabirsh +5 more
doaj +1 more source