Results 31 to 40 of about 589,835 (315)

Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies [PDF]

, 2012
Modelling class B G-protein-coupled receptors (GPCRs) using class A GPCR structural templates is difficult due to lack of homology. The plant GPCR, GCR1, has homology to both class A and class B GPCRs. We have used this to generate a class A–
Poyner, David, Reynolds, Christopher A., Hay, Debbie L., Poyner, David R, Barwell, James, Upton, Graham J.G., Poyner, David R., Reeves, Philip J., Upton, Graham J. G., Taddese, Bruck, Reeves, Philip J, Reynolds, Christopher A, Conner, Alex C., Hay, Debbie L, Conner, Alex C, Vohra, Shabana, Upton, Graham JG   +16 more
core   +1 more source

Competing G protein‐coupled receptor kinases balance G protein and β‐arrestin signaling

Molecular Systems Biology, 2012
Seven‐transmembrane receptors (7TMRs) are involved in nearly all aspects of chemical communications and represent major drug targets. 7TMRs transmit their signals not only via heterotrimeric G proteins but also through β‐arrestins, whose recruitment to ...
Domitille Heitzler, Guillaume Durand, Nathalie Gallay, Aurélien Rizk, Seungkirl Ahn, Jihee Kim, Jonathan D Violin, Laurence Dupuy, Christophe Gauthier, Vincent Piketty, Pascale Crépieux, Anne Poupon, Frédérique Clément, François Fages, Robert J Lefkowitz, Eric Reiter   +15 more
doaj   +1 more source

Significance of G Protein-Coupled Estrogen Receptor in the Pathophysiology of Irritable Bowel Syndrome, Inflammatory Bowel Diseases and Colorectal Cancer

Frontiers in Endocrinology, 2020
The regulatory role of estrogens and nuclear estrogen receptors, i. e., estrogen receptor α and β has been reported in gastrointestinal diseases. However, the contribution of G protein-coupled estrogen receptor, the membrane-bound estrogen receptor, is ...
Damian Jacenik, Wanda M. Krajewska
doaj   +1 more source

Evolution of vertebrate GnRH receptors from the perspective of a basal vertebrate

Frontiers in Endocrinology, 2012
This minireview provides the current status on gonadotropin-releasing hormone receptors (GnRH-R) in vertebrates, from the perspective of a basal vertebrate, the sea lamprey, and provides an evolutionary scheme based on the recent advance of whole genome ...
Stacia A Sower, Wayne A Decatur, Nerine T Joseph, Mihael eFreamat   +3 more
doaj   +1 more source

Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget’s Disease of Bone

Cells, 2023
Paget’s Disease of Bone (PDB) is a metabolic bone disease that is characterized by dysregulated osteoclast function leading to focal abnormalities of bone remodeling. It can lead to pain, fracture, and bone deformity. G protein-coupled receptor kinase 3 (
Emily M. Rabjohns, Rishi R. Rampersad, Arin Ghosh, Katlyn Hurst, Amanda M. Eudy, Jaime M. Brozowski, Hyun Ho Lee, Yinshi Ren, Anthony Mirando, Justin Gladman, Jessica L. Bowser, Kathryn Berg, Sachin Wani, Stuart H. Ralston, Matthew J. Hilton, Teresa K. Tarrant   +15 more
doaj   +1 more source

G Protein–Coupled Receptor Deorphanizations [PDF]

Annual Review of Pharmacology and Toxicology, 2013
G protein–coupled receptors (GPCRs) are major regulators of intercellular interactions. They initiate these actions by being activated by a wide variety of natural ligands. Historically, ligands were discovered first, but the advent of molecular biology reversed this trend.
Olivier, Civelli, Rainer K, Reinscheid, Yan, Zhang, Zhiwei, Wang, Robert, Fredriksson, Helgi B, Schiöth   +5 more
openaire   +2 more sources

The Expression Pattern of Adhesion G Protein-Coupled Receptor F5 Is Related to Cell Adhesion and Metastatic Pathways in Colorectal Cancer—Comprehensive Study Based on In Silico Analysis

Cells, 2022
Adhesion G protein-coupled receptor F5 (ADGRF5) is involved inthe neoplastic transformation of some cancer types. However, the significance of ADGRF5 expression signature and the impact of signaling pathways mediated by ADGRF5 during neoplastic ...
Huining Kang, Jakub Fichna, Ksenia Matlawska-Wasowska, Damian Jacenik   +3 more
doaj   +1 more source

G-protein-coupled receptors at a glance [PDF]

Journal of Cell Science, 2003
[No abstract available]
Wesley K, Kroeze, Douglas J, Sheffler, Bryan L, Roth   +2 more
openaire   +2 more sources

G-protein-coupled receptor kinases

Kidney International, 1996
beta-Adrenergic receptors are prototypes of the many G-protein-coupled receptors. Activation and inactivation of these receptors are regulated by multiple mechanisms which can affect either their function or their expression. The most obvious changes of such receptor systems are induced by activation of the receptors themselves by their respective ...
Lohse, Martin J., Krasel, Cornelius, Winstel, Rainer, Mayor, Federico   +3 more
openaire   +2 more sources

Trafficking of G Protein–Coupled Receptors [PDF]

Circulation Research, 2006
G protein–coupled receptors (GPCRs) play an integral role in the signal transduction of an enormous array of biological phenomena, thereby serving to modulate at a molecular level almost all components of human biology. This role is nowhere more evident than in cardiovascular biology, where GPCRs regulate such core measures of cardiovascular function ...
Drake, Matthew T, Shenoy, Sudha K, Lefkowitz, Robert J   +2 more
openaire   +2 more sources