Results 1 to 10 of about 396,098 (353)

Historical Perspective of the G Protein-Coupled Receptor Kinase Family [PDF]

Cells, 2021
Agonist activation of G protein-coupled receptors promotes sequential interaction of the receptor with heterotrimeric G proteins, G protein-coupled receptor kinases (GRKs), and arrestins. GRKs play a central role in mediating the switch from G protein to
Jeffrey L. Benovic
doaj   +5 more sources

Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases. [PDF]

Journal of Biological Chemistry, 1994
The thrombin receptor, a member of the seven membrane-spanning superfamily of G-protein coupled receptors, is activated by an irreversible proteolytic mechanism, but signaling by activated thrombin receptors shuts off soon after receptor activation. This shut-off mechanism is thought to be required for concentration-dependent responses to thrombin and ...
Kenji Ishii, J. Chen, Maki Ishii, Walter J. Koch, Neil J. Freedman, R J Lefkowitz, Shaun R. Coughlin   +6 more
openalex   +3 more sources

G protein-coupled receptor kinase 2 promotes cardiac hypertrophy. [PDF]

PLoS ONE, 2017
The increase in protein activity and upregulation of G-protein coupled receptor kinase 2 (GRK2) is a hallmark of cardiac stress and heart failure. Inhibition of GRK2 improved cardiac function and survival and diminished cardiac remodeling in various ...
Philipp Schlegel, Julia Reinkober, Eric Meinhardt, Henrike Tscheschner, Erhe Gao, Sarah M Schumacher, Ancai Yuan, Johannes Backs, Patrick Most, Thomas Wieland, Walter J Koch, Hugo A Katus, Philip W Raake   +12 more
doaj   +2 more sources

G‐protein coupled receptor kinases as modulators of G‐protein signalling

The Journal of Physiology, 1999
G‐protein coupled receptors (GPCRs) comprise one of the largest classes of signalling molecules. A wide diversity of activating ligands induce the active conformation of GPCRs and lead to signalling via heterotrimeric G‐proteins and downstream effectors.
Moritz Bünemann, Marie Thérèse Hosey
openalex   +5 more sources

Insulin signaling inhibits the 5-HT_2C receptor in choroid plexus via MAP kinase [PDF]

BMC Neuroscience, 2003
Background G protein-coupled receptors (GPCRs) interact with heterotrimeric GTP-binding proteins (G proteins) to modulate acute changes in intracellular messenger levels and ion channel activity.
Guan Kunliang, DePaoli-Roach Anna A, Marshall Mark S, Bye Leighan S, Zhang Shengwen, Hurley Joyce H, Fox Aaron P, Yu Lei   +7 more
doaj   +5 more sources

The Open Question of How GPCRs Interact with GPCR Kinases (GRKs)

Biomolecules, 2021
G protein-coupled receptors (GPCRs), which regulate a vast number of eukaryotic processes, are desensitized by various mechanisms but, most importantly, by the GPCR kinases (GRKs).
M. Claire Cato, Yu-Chen Yen, Charnelle J. Francis, Kaely E. Elkins, Afzaal Shareef, Rachel Sterne-Marr, John J. G. Tesmer   +6 more
doaj   +1 more source

Targeting G protein–coupled receptor kinases to G protein–coupled receptors

Current Opinion in Endocrine and Metabolic Research, 2021
G protein-coupled receptors (GPCRs) interact with three protein families following agonist binding: heterotrimeric G proteins, G protein-coupled receptor kinases (GRKs) and arrestins. GRK-mediated phosphorylation of GPCRs promotes arrestin binding to uncouple the receptor from G protein, a process called desensitization, and for many GPCRs, arrestin ...
Jeffrey L. Benovic, Sarah M. Sulon
openaire   +4 more sources

G PROTEIN–COUPLED RECEPTOR KINASES [PDF]

Annual Review of Biochemistry, 1998
G protein–coupled receptor kinases (GRKs) constitute a family of six mammalian serine/threonine protein kinases that phosphorylate agonist-bound, or activated, G protein–coupled receptors (GPCRs) as their primary substrates. GRK-mediated receptor phosphorylation rapidly initiates profound impairment of receptor signaling, or desensitization.
Robert J. Lefkowitz, Julie A. Pitcher, Neil J. Freedman   +2 more
openaire   +3 more sources

G-protein-coupled receptor kinases

Kidney International, 1996
beta-Adrenergic receptors are prototypes of the many G-protein-coupled receptors. Activation and inactivation of these receptors are regulated by multiple mechanisms which can affect either their function or their expression. The most obvious changes of such receptor systems are induced by activation of the receptors themselves by their respective ...
Federico Mayor, Martin J. Lohse, Cornelius Krasel, Rainer Winstel   +3 more
openaire   +4 more sources

G-Protein-Coupled Receptor Kinases in Hypertension [PDF]

High Blood Pressure & Cardiovascular Prevention, 2013
[No abstract available]
CARNEVALE, DANIELA, LEMBO, Giuseppe
openaire   +4 more sources