Results 11 to 20 of about 536,609 (348)

Regulation of Membrane Targeting of the G Protein-coupled Receptor Kinase 2 by Protein Kinase A and Its Anchoring Protein AKAP79 [PDF]

Journal of Biological Chemistry, 2001
The beta 2 adrenergic receptor (beta 2AR) undergoes desensitization by a process involving its phosphorylation by both protein kinase A (PKA) and G protein-coupled receptor kinases (GRKs). The protein kinase A-anchoring protein AKAP79 influences beta 2AR
Chen, Wei, Cong, Mei, Fraser, Iain D., Hu, Liaoyuan A., Lefkowitz, Robert J., Lin, Fang-Tsyr, Perry, Stepehn J., Pitcher, Julie A., Scott, John D.   +8 more
core   +2 more sources

Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1. [PDF]

Nature, 2021
G-protein-coupled receptor (GPCR) kinases (GRKs) selectively phosphorylate activated GPCRs, thereby priming them for desensitization1. Although it is unclear how GRKs recognize these receptors2–4, a conserved region at the GRK N terminus is essential for
Chen Q, Plasencia M, Li Z, Mukherjee S, Patra D, Chen CL, Klose T, Yao XQ, Kossiakoff AA, Chang L, Andrews PC, Tesmer JJG.   +11 more
europepmc   +2 more sources

G Protein-Coupled Receptor Kinase [PDF]

Definitions, 2020
openaire   +2 more sources

G protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling hub. [PDF]

Cell Mol Life Sci, 2019
Accumulating evidence indicates that G protein-coupled receptor kinase 2 (GRK2) is a versatile protein that acts as a signaling hub by modulating G protein-coupled receptor (GPCR) signaling and also via phosphorylation or scaffolding interactions with an
Penela P, Ribas C, Sánchez-Madrid F, Mayor F.   +3 more
europepmc   +2 more sources

Differential Signaling Profiles of MC4R Mutations with Three Different Ligands [PDF]

, 2020
The melanocortin 4 receptor (MC4R) is a key player in hypothalamic weight regulation and energy expenditure as part of the leptin-melanocortin pathway. Mutations in this G protein coupled receptor (GPCR) are the most common cause for monogenetic obesity,
Annibale, Paolo, Biebermann, Heike, Dimitriou, Ioanna Maria, Krude, Heiko, Kühnen, Peter, Lohse, Martin J., Paisdzior, Sarah, Scheerer, Patrick, Schöpe, Paul Curtis   +8 more
core   +3 more sources

G protein receptor kinase type 2: A novel target in cardiovascular drug development [PDF]

Hospital Pharmacology, 2014
In spite of significant advancement in pharmacotherapy, heart failure remains one of the main causes of death worldwide. The existing treatment of heart failure prolongs life span by slowing down the pathological process but does not induce heart healing.
Vasić Marko S., Japundžić-Žigon Nina M.   +1 more
doaj   +1 more source

Comparison of MEK/ERK pathway inhibitors on the upregulation of vascular G-protein coupled receptors in rat cerebral arteries [PDF]

, 2010
Organ culture is an in vitro method for investigating cellular mechanisms involved in upregulation of vasocontractile G-protein coupled receptors. We hypothesize that mitogen-activated-protein kinase (MEK) and/or extracellular-signal-regulated kinase ...
Ansar, S., Edvinsson, L., Sandhu, Hardip
core   +1 more source

G-protein-coupled receptor kinases

Trends in Biochemical Sciences, 1991
Rhodopsin kinase and the beta-adrenergic receptor kinase (beta ARK) catalyse the phosphorylation of the activated forms of the G-protein-coupled receptors, rhodopsin and the beta 2-adrenergic receptor (beta 2AR), respectively. The interaction between receptor and kinase is independent of second messengers and appears to involve a multipoint attachment ...
Palczewskl, Krzvsztof, Benovic, Jeffrey L   +1 more
openaire   +4 more sources

C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor

eLife, 2015
Rod photoreceptors generate measurable responses to single-photon activation of individual molecules of the G protein-coupled receptor (GPCR), rhodopsin.
Anthony W Azevedo, Thuy Doan, Hormoz Moaven, Iza Sokal, Faiza Baameur, Sergey A Vishnivetskiy, Kristoff T Homan, John JG Tesmer, Vsevolod V Gurevich, Jeannie Chen, Fred Rieke   +10 more
doaj   +1 more source

Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5. [PDF]

, 2017
The phosphorylation of agonist-occupied G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) functions to turn off G-protein signaling and turn on arrestin-mediated signaling.
Adams, Christopher M., Benovic, Jeffrey L., Betz, Robin M., Chung, Ka Young, Dror, Ron O., Du, Yang, Duc, Nguyen Minh, Kobilka, Brian K., Komolov, Konstantin E., Leib, Ryan D., Patra, Dhabaleswar, Rodrigues, João P.G.L.M., Skiniotis, Georgios   +12 more
core   +2 more sources