Results 11 to 20 of about 257,626 (261)

G PROTEIN–COUPLED RECEPTOR KINASES [PDF]

Annual Review of Biochemistry, 1998
G protein–coupled receptor kinases (GRKs) constitute a family of six mammalian serine/threonine protein kinases that phosphorylate agonist-bound, or activated, G protein–coupled receptors (GPCRs) as their primary substrates. GRK-mediated receptor phosphorylation rapidly initiates profound impairment of receptor signaling, or desensitization.
J A, Pitcher, N J, Freedman, R J, Lefkowitz   +2 more
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Targeting G protein–coupled receptor kinases to G protein–coupled receptors

Current Opinion in Endocrine and Metabolic Research, 2021
G protein-coupled receptors (GPCRs) interact with three protein families following agonist binding: heterotrimeric G proteins, G protein-coupled receptor kinases (GRKs) and arrestins. GRK-mediated phosphorylation of GPCRs promotes arrestin binding to uncouple the receptor from G protein, a process called desensitization, and for many GPCRs, arrestin ...
Sarah M, Sulon, Jeffrey L, Benovic
openaire   +3 more sources

G-Protein-Coupled Receptor Kinases in Hypertension [PDF]

High Blood Pressure & Cardiovascular Prevention, 2013
[No abstract available]
CARNEVALE, DANIELA, LEMBO, Giuseppe
openaire   +3 more sources

G-protein-coupled receptor kinases in inflammation and disease [PDF]

Genes & Immunity, 2015
G-protein-coupled receptor kinases (GRKs) are serine/threonine protein kinases originally discovered for their role in G-protein-coupled receptor (GPCR) phosphorylation. Recent studies have demonstrated a much broader function for this kinase family including phosphorylation of cytosolic substrates involved in cell signaling pathways stimulated by ...
Packiriswamy, Nandakumar, Parameswaran, Narayanan   +1 more
openaire   +2 more sources

G-protein-coupled receptor kinases

Kidney International, 1996
beta-Adrenergic receptors are prototypes of the many G-protein-coupled receptors. Activation and inactivation of these receptors are regulated by multiple mechanisms which can affect either their function or their expression. The most obvious changes of such receptor systems are induced by activation of the receptors themselves by their respective ...
Lohse, Martin J., Krasel, Cornelius, Winstel, Rainer, Mayor, Federico   +3 more
openaire   +2 more sources

G protein-coupled receptor kinase 2 promotes cardiac hypertrophy.

PLoS ONE, 2017
The increase in protein activity and upregulation of G-protein coupled receptor kinase 2 (GRK2) is a hallmark of cardiac stress and heart failure. Inhibition of GRK2 improved cardiac function and survival and diminished cardiac remodeling in various ...
Philipp Schlegel, Julia Reinkober, Eric Meinhardt, Henrike Tscheschner, Erhe Gao, Sarah M Schumacher, Ancai Yuan, Johannes Backs, Patrick Most, Thomas Wieland, Walter J Koch, Hugo A Katus, Philip W Raake   +12 more
doaj   +1 more source

G-protein-coupled receptor kinases

Trends in Biochemical Sciences, 1991
Rhodopsin kinase and the beta-adrenergic receptor kinase (beta ARK) catalyse the phosphorylation of the activated forms of the G-protein-coupled receptors, rhodopsin and the beta 2-adrenergic receptor (beta 2AR), respectively. The interaction between receptor and kinase is independent of second messengers and appears to involve a multipoint attachment ...
Palczewskl, Krzvsztof, Benovic, Jeffrey L   +1 more
openaire   +4 more sources

G Protein Coupled Receptor Kinase 3 Regulates Breast Cancer Migration, Invasion, and Metastasis. [PDF]

PLoS ONE, 2016
Triple negative breast cancer (TNBC) is a heterogeneous disease that has a poor prognosis and limited treatment options. Chemokine receptor interactions are important modulators of breast cancer metastasis; however, it is now recognized that quantitative
Matthew J Billard, David J Fitzhugh, Joel S Parker, Jaime M Brozowski, Marcus W McGinnis, Roman G Timoshchenko, D Stephen Serafin, Ruth Lininger, Nancy Klauber-Demore, Gary Sahagian, Young K Truong, Maria F Sassano, Jonathan S Serody, Teresa K Tarrant   +13 more
doaj   +1 more source

Regulation Role of Non-Rhodopsin G Protein-coupled Receptor Kinases on Tumor

Zhongliu Fangzhi Yanjiu, 2019
G protein-coupled receptor kinases (GRKs) are involved in a wide range of cellular physiology and pathological activities by specifically phosphorylating activated G-protein coupled receptors (GPCRs) to terminate GPCR signaling and phosphorylating non ...
LI Ruirui, JIANG Xiaoshan
doaj   +1 more source

GIT1 protects against breast cancer growth through negative regulation of Notch

Nature Communications, 2022
Notch signalling is reported to be hyperactivated in oestrogen receptor-negative (ER-) breast cancer. Here the authors show that G protein-coupled receptor kinase-interacting protein 1 (GIT1) negatively regulates Notch signalling and tumour growth in ER-
Songbai Zhang, Ayako Miyakawa, Malin Wickström, Cecilia Dyberg, Lauri Louhivuori, Manuel Varas-Godoy, Kati Kemppainen, Shigeaki Kanatani, Dagmara Kaczynska, Ivar Dehnisch Ellström, Lotta Elfman, Pauliina Kronqvist, Heli Repo, Katsuhiko Mikoshiba, Cecilia Sahlgren, John Inge Johnsen, Per Uhlén   +16 more
doaj   +1 more source