Results 151 to 160 of about 427,218 (207)

The structure of the skeletal and nonskeletal muscle calcium channel [PDF]

, 1989
Biel, Martin, Felbel, J., Flockerzi, Veit, Gehring, U., Hofmann, Franz, Nastainczyk, E., Regulla, S., Ruth, Peter, Schneider, T.   +8 more
core   +1 more source

G Protein-Coupled Receptor Kinase 4 [PDF]

, 2020
openaire   +1 more source

Development of a new class of potent and highly selective G protein-coupled receptor kinase 5 inhibitors and structural insight from crystal structures of inhibitor complexes. [PDF]

Eur J Med Chem
Chen Y, Sonawane A, Manda R, Gadi RK, Tesmer JJG, Ghosh AK.   +5 more
europepmc   +1 more source

Editorial: GPCRs: signal transduction

Frontiers in Molecular Biosciences
Nicole Perry-Hauser, Nicole Perry-Hauser, Stuart Maudsley, Yamina A. Berchiche, Lauren M. Slosky   +4 more
doaj   +1 more source

G-Protein-Coupled Receptor Kinase-Interacting Protein 1 (GIT1) Promotes Head and Neck Squamous Cell Carcinoma Metastases via Activating the PI3K/AKT/mTOR Signal Pathway.

Comput Math Methods Med, 2022
Xu R, Xu R, Wang Y, Wang W, Jiang L, Gong S.   +5 more
europepmc   +1 more source

G protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling hub. [PDF]

Cell Mol Life Sci, 2019
Penela P, Ribas C, Sánchez-Madrid F, Mayor F.   +3 more
europepmc   +1 more source

Signalling mechanisms used by the orexin-1 receptor [PDF]

Peltonen, Hanna
core  

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G protein—coupled receptor kinases

Cell, 1993
G protein‐coupled receptor kinases (GRKs) constitute a family of six mammalian serine/threonine protein kinases that phosphorylate agonist-bound, or activated, G protein‐coupled receptors (GPCRs) as their primary substrates. GRK-mediated receptor phosphorylation rapidly initiates profound impairment of receptor signaling, or desensitization.
openaire   +2 more sources

Regulation of G Protein-Coupled Receptor Kinases

Trends in Cardiovascular Medicine, 2000
G protein-coupled receptor kinases (GRKs) specifically interact with the agonist-activated form of G protein-coupled receptors (GPCRs) to effect receptor phosphorylation and desensitization. Recent studies demonstrate that GRK function is a highly regulated process, and it is perhaps in this manner that a handful of GRKs (7 have been identified to date)
R B, Penn, A N, Pronin, J L, Benovic
openaire   +2 more sources