G protein-coupled receptor kinase

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Regulation of G protein-coupled receptor kinase 2

2002
Publisher Summary G protein-coupled receptor kinase 2 (GRK2) was originally termed a “β-adrenergic receptor kinase” (βARK) because it was purified as a kinase of the adrenergic β 2 receptor, and the adrenergic β 2 receptor was the only known substrate of GRK2. GRK2 is now known to phosphorylate different kinds of G protein-coupled receptors (GPCRs),
Tatsuya, Haga +4 more
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G Protein‐Coupled Receptor Kinases

Journal of Neurochemistry, 1994
T, Haga, K, Haga, K, Kameyama
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Targeting G protein-coupled receptor kinases (GRKs) to G protein-coupled receptors.

Current opinion in endocrine and metabolic research
G protein-coupled receptors (GPCRs) interact with three protein families following agonist binding: heterotrimeric G proteins, G protein-coupled receptor kinases (GRKs) and arrestins. GRK-mediated phosphorylation of GPCRs promotes arrestin binding to uncouple the receptor from G protein, a process called desensitization, and for many GPCRs, arrestin ...
Sarah M, Sulon, Jeffrey L, Benovic
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Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly

Chimeric antigen receptor T‐cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice

Ca-A Cancer Journal for Clinicians, 2023
Rujul Parikh
exaly

Critical care management of chimeric antigen receptor T‐cell therapy recipients

Ca-A Cancer Journal for Clinicians, 2022
Alexander Shimabukuro-Vornhagen, Victoria Metaxa, Elie Azoulay +2 more
exaly

G-protein-coupled receptor kinases and arrestins: regulators of G-protein-coupled receptor sequestration