Results 181 to 190 of about 14,338,489 (301)

G Protein-Coupled Receptor Kinase 5 (GRK5) Modulates Nociceptin/Orphanin FQ Opioid (NOP) Receptor Desensitization in Rat Sympathetic Neurons. [PDF]

J Neurosci Res
Farrag M, Soliman M, Mahmoud S, Miller L, Herold PB, Brandt K, Ruiz-Velasco V.   +6 more
europepmc   +1 more source

Endothelin receptor B enhances liver injury and pro-inflammatory responses by increasing G-protein-coupled receptor kinase-2 expression in primary biliary cholangitis. [PDF]

Sci Rep, 2022
Xu G, Gong Y, Lu F, Wang B, Yang Z, Chen L, Min J, Cheng C, Jiang T.   +8 more
europepmc   +1 more source

Clinical characteristics and concordance of anti‐MDA5 autoantibodies: A multicentre Australian study

Arthritis Care &Research, Accepted Article.
Objectives In Australia, anti‐MDA5 antibodies are exclusively tested by line immunoblot assay (LIA). The clinical concordance of a LIA‐positive anti‐MDA5 result is unclear. We aimed to describe the clinical features and determine the clinical concordance of patients with anti‐MDA5 antibodies.
Syed B Ali, Thomas Khoo, Keeran Shivakumar, Adam Caroll, Lauren Hender, Dimitra Beroukas, Kim Griggs, Celina Jin, Theo De Malmanche, Jessica Day, Gabor Major, Vidya Limaye   +11 more
wiley   +1 more source

Pharmacological inhibition of G protein-coupled receptor kinase 5 decreases high-fat diet-induced hepatic steatosis in mice. [PDF]

Biochem Biophys Res Commun
Seramur ME, Sink S, Reeves TE, Solberg Woods LC, Chuang Key CC.   +4 more
europepmc   +1 more source

G-protein-coupled receptor kinase 4 causes renal angiotensin II type 2 receptor dysfunction by increasing its phosphorylation. [PDF]

Clin Sci (Lond), 2022
Zhang F, Lei L, Huang J, Wang W, Su Q, Yan H, Chen C, Zheng S, Ren H, Li Z, Jose PA, Hu Y, Si L, Zeng C, Yang J.   +14 more
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

The role of G protein-coupled receptor kinase 4 in cardiomyocyte injury after myocardial infarction. [PDF]

Eur Heart J, 2021
Li L, Fu W, Gong X, Chen Z, Tang L, Yang D, Liao Q, Xia X, Wu H, Liu C, Tian M, Zeng A, Zhou L, Jose PA, Chen K, Wang WE, Zeng C.   +16 more
europepmc   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

G-Protein-Coupled Receptor Kinase 2 Limits CCL21-Induced T Cell Migration via Phospholipase Cγ1. [PDF]

Receptors (Basel)
Sanchez A, Winebrenner CT, Garcia N, Kaiser B, Kilgore L, Cardona CI, Bassuk DW, Miller ME, Bill CA, Shannon LA, Wagener BM, Wagler A, Llano M, Bill CA, Vines CM.   +14 more
europepmc   +1 more source

The Hypertension Related Gene G-Protein Coupled Receptor Kinase 4 Contributes to Breast Cancer Proliferation. [PDF]

Breast Cancer (Auckl), 2021
Yue W, Tran HT, Wang JP, Schiermeyer K, Gildea JJ, Xu P, Felder RA.   +6 more
europepmc   +1 more source