G-protein coupled receptor kinase-2 regulates the migration of chronic lymphocytic leukaemia cells to sphingosine-1 phosphate in vitro and their trafficking in vivo. [PDF]
Sci RepCassarino MC +14 more
europepmc +1 more source
Threonine 308 within a Putative Casein Kinase 2 Site of the Cytoplasmic Tail of Leukotriene B4 Receptor (BLT1) Is Crucial for Ligand-induced, G-protein-coupled Receptor-specific Kinase 6-mediated Desensitization [PDF]
, 2002 Rémi Gaudreau +4 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.A) SLM generates biomimetic bone scaffolds with consistent porosity but varying TPMS‐Gyroid unit cell designs (TG15, TG20, TG25, TG30). B) By enhancing the expression of ITGB1, TPMS‐Gyroid scaffolds can facilitate osteogenic differentiation in BMSCs and promote M2 polarization in macrophages.
Jing Wang +9 more
wiley +1 more source
Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy
Advanced Healthcare Materials, EarlyView.The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq +4 more
wiley +1 more source
Anabolic effects of a G protein–coupled receptor kinase inhibitor expressed in osteoblasts [PDF]
, 2002 Robert F. Spurney +6 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.A phosphodiester‐backboned bottlebrush polymer (pacDNA) engineered for aptamer delivery is presented. This design enhances aptamer stability, plasma pharmacokinetics, and target engagement in vivo. In AXL‐driven cancer models, pacDNA inhibits AXL signaling and reduces tumor growth, highlighting the promise of precision polymer scaffolds in aptamer ...
Tingyu Sun +13 more
wiley +1 more source
Development of a new class of potent and highly selective G protein-coupled receptor kinase 5 inhibitors and structural insight from crystal structures of inhibitor complexes. [PDF]
Eur J Med ChemChen Y +5 more
europepmc +1 more source
Extracellular signal‐regulated kinases control expression of G protein‐coupled receptor kinase 2 (GRK2) [PDF]
, 2002 Juliane Theilade +3 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.This study introduces a controllable degradation system for Mg‐based biomaterials using sputtering technology, marking a significant advancement in nerve regeneration research. The Mg‐sputtered nerve conduits demonstrate enhanced biocompatibility, biofunctionality, mechanical compatibility, and precise magnesium release, resulting in improved axonal ...
Hyewon Kim +12 more
wiley +1 more source