Results 211 to 220 of about 246,187 (261)

Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils

Advanced Science, EarlyView.
We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr, Anne Schmitz, Meshkat Dinarvand, Franziska Wulfert, Sangeetha Shankar, Bjoern F. Hill, Michael Wojak, Juliana Gretz, Marie Britz, Elsa Neubert, Magdalena Shumanska, Sofia Kaushik, Linda Kartaschew, Ivan Bogeski, James Daniel, Sebastian Jung, Johannes Eble, Guido Wabnitz, Luise Erpenbeck, Sebastian Kruss   +19 more
wiley   +1 more source

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Regulation of G Protein-Coupled Receptor Kinases

Trends in Cardiovascular Medicine, 2000
G protein-coupled receptor kinases (GRKs) specifically interact with the agonist-activated form of G protein-coupled receptors (GPCRs) to effect receptor phosphorylation and desensitization. Recent studies demonstrate that GRK function is a highly regulated process, and it is perhaps in this manner that a handful of GRKs (7 have been identified to date)
R B, Penn, A N, Pronin, J L, Benovic
openaire   +2 more sources

G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins

Canadian Journal of Physiology and Pharmacology, 1996
G-protein-coupled receptors (GPCRs) represent a large family of proteins that transduce extracellular signals to the interior of cells. Signalling through these receptors rapidly desensitized primarily as the consequence of receptor phosphorylation, but receptor sequestration and downregulation can also contribute to this process.
S S, Ferguson, L S, Barak, J, Zhang, M G, Caron   +3 more
openaire   +2 more sources

G protein—coupled receptor kinases

Cell, 1993
G protein‐coupled receptor kinases (GRKs) constitute a family of six mammalian serine/threonine protein kinases that phosphorylate agonist-bound, or activated, G protein‐coupled receptors (GPCRs) as their primary substrates. GRK-mediated receptor phosphorylation rapidly initiates profound impairment of receptor signaling, or desensitization.
openaire   +2 more sources

Characterization of G protein-coupled receptor kinases

2002
Publisher Summary A basic feature of most cells is the ability to dynamically regulate their responsiveness to extracellular stimuli. Numerous stimuli transmit their signals via interaction with cell surface G protein-coupled receptors (GPCRs). GPCRs are subject to three principal modes of regulation: (1) desensitization, the process by which a ...
Alexey N, Pronin, Robert P, Loudon, Jeffrey L, Benovic   +2 more
openaire   +2 more sources

G-protein-coupled receptor kinases and the heart

Trends in Cardiovascular Medicine, 1995
The family of G-protein-coupled receptors includes many well-studied members, such as the adrenergic and the muscarinic acetylcholine receptors. These receptors are regulated by multiple mechanisms that serve to adapt their expression and their function to a rapidly changing environment.
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Targeting G protein-coupled receptor kinases to their receptor substrates

Journal of Membrane Biology, 1997
Membrane association is essential for GRK function and because of this the GRKs have evolved complex regulatory mechanisms for associating with the membrane. Although the GRKs are highly homologous, each kinase utilizes a distinct mechanism for associating with the membrane, which makes it unique within the family.
R H, Stoffel, J A, Pitcher, R J, Lefkowitz   +2 more
openaire   +2 more sources

G Protein Coupled Receptor Kinases

2007
G protein-coupled receptor kinases (GRKs) belong to the AGC family of serine/threonine kinases. They phosphorylate agonist-activated G protein-coupled receptors (hence the name). This phosphorylation triggers the binding of arrestins to the receptors.
Cornelius Krasel, Martin J. Lohse
openaire   +1 more source

Peptide inhibitors of G protein-coupled receptor kinases

Biochemical Pharmacology, 2005
G protein-coupled receptor kinases (GRKs) are regulatory enzymes involved in the modulation of seven-transmembrane-helix receptors. In order to develop specific inhibitors for these kinases, we synthesized and investigated peptide inhibitors derived from the sequence of the first intracellular loop of the beta2-adrenergic receptor.
Rainer, Winstel, Hans-Georg, Ihlenfeldt, Günther, Jung, Cornelius, Krasel, Martin J, Lohse   +4 more
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Pathophysiological roles of G-protein-coupled receptor kinases

Cellular Signalling, 2005
G-protein-coupled receptor kinases (GRKs) interact with the agonist-activated form of G-protein-coupled receptors (GPCRs) to effect receptor phosphorylation and to initiate profound impairment of receptor signalling, or desensitization. GPCRs form the largest family of cell surface receptors known and defects in GRK function have the potential ...
Thierry, Métayé, Hélène, Gibelin, Rémy, Perdrisot, Jean-Louis, Kraimps   +3 more
openaire   +2 more sources