Results 221 to 230 of about 536,609 (348)

G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation. [PDF]

Stem Cell Res Ther, 2022
Brozowski JM, Timoshchenko RG, Serafin DS, Allyn B, Koontz J, Rabjohns EM, Rampersad RR, Ren Y, Eudy AM, Harris TF, Abraham D, Mattox D, Rubin CT, Hilton MJ, Rubin J, Allbritton NL, Billard MJ, Tarrant TK.   +17 more
europepmc   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Structural insights into the catalytic cycle of G protein-coupled receptor kinase 5 and a possible regulatory site for potassium ion. [PDF]

J Biol Chem
Chen Y, Tesmer JJG.
europepmc   +1 more source

G protein-coupled receptor kinase 2 modifies the ability of Caenorhabditis elegans to survive oxidative stress. [PDF]

Cell Stress Chaperones, 2021
Henry SA, Crivello S, Nguyen TM, Cybulska M, Hoang NS, Nguyen M, Badial T, Emami N, Awada N, Woodward JF, So CH.   +10 more
europepmc   +1 more source

Designed Liquid Crystalline Nanoassemblies From Clinically Validated Polyunsaturated Lipids for Combined Antioxidant, Anti‐Apoptotic, and Neurotrophic Treatments

Advanced Healthcare Materials, EarlyView.
Ionizable lipid nanoparticles target multiple pathological pathways in neurodegeneration. The designed self‐assembled materials undergo a pH‐triggered structural transformation from a cubosome/hexosome coexistence to a hexosome phase, enhancing intracellular delivery of a multi‐target phytochemical formulation. The antioxidant‐loaded pH‐responsive LNPs
Thelma Akanchise, Fucen Luo, Borislav Angelov, Yuru Deng, Angelina Angelova   +4 more
wiley   +1 more source

The roles of G protein-coupled receptor kinase 2 in renal diseases. [PDF]

J Cell Mol Med
Du J, Wu X, Ni L.
europepmc   +1 more source

Characterization of the G protein-coupled receptor kinase 6 promoter reveals a functional CREB binding site. [PDF]

PLoS One, 2021
Stegen M, Engler A, Ochsenfarth C, Manthey I, Peters J, Siffert W, Frey UH.   +6 more
europepmc   +1 more source

One‐Step Microfluidic Manufactured Fucose‐Decorated Sweetosomes Choose the Time and the Road for Their Intracellular Journey to Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Sweetosomes, a new class of fucose‐decorated liposomes, are developed via a one‐step microfluidic process without surface chemistry. This study elucidates their main caveolae‐mediated entry and distinct endosomal trafficking. These nanostructures demonstrate superior endosomal escape, organelle acidity modulation, and prolonged plasma persistence ...
Mattia Tiboni, Mariele Montanari, Shiva Khorshid, Michele Verboni, Andrea Duranti, Simone Lucarini, Daniele Lopez, Annalisa Aluigi, Gianluca Morganti, Michele Menotta, Giovanna Panza, Daniel J. Klionsky, Barbara Canonico, Luca Casettari   +13 more
wiley   +1 more source

Canonical or non-canonical, all aspects of G protein-coupled receptor kinase 2 in heart failure. [PDF]

Acta Physiol (Oxf)
Kaplan A, El-Samadi L, Zahreddine R, Amin G, Booz GW, Zouein FA.   +5 more
europepmc   +1 more source

Generation of Highly Selective, Potent, and Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors. [PDF]

J Med Chem, 2021
Rowlands RA, Chen Q, Bouley RA, Avramova LV, Tesmer JJG, White AD.   +5 more
europepmc   +1 more source