Results 221 to 230 of about 246,187 (261)

G Protein-Coupled Receptor Kinases

2005
As the largest family of membrane receptors, G protein-coupled receptors (GPCRs) transduce a large number of extracellular signals from hormones, neurotransmitters, chemokines, and other environmental stimuli to the interior of cells and play fundamental roles in the regulation of cellular functions.
Lan Ma, Jingxia Gao, Xiaoqing Chen
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Regulation of G Protein-Coupled Receptor Kinases by Phospholipids

Current Medicinal Chemistry, 2012
G protein coupled-receptor (GPCR) kinases (GRKs) initiate the deactivation of GPCRs by phosphorylating their cytoplasmic loops and C-terminal tails. They are regulated not only by allosteric interactions with activated GPCRs, but also by the membrane environment itself.
K T, Homan, A, Glukhova, J J G, Tesmer
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G-Protein–coupled receptor kinase expression in hypertension

Clinical Pharmacology & Therapeutics, 1999
In human hypertension we have recently identified an increase in lymphocyte G-protein receptor kinase-2 (GRK-2) protein expression, the key protein regulating the interaction between G-protein-coupled receptors and activation of adenylyl cyclase. However, it was not known whether this increase in GRK-2 protein expression was attributable to regulation ...
R, Gros, C M, Tan, J, Chorazyczewski, D J, Kelvin, J L, Benovic, R D, Feldman   +5 more
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Regulation of G Protein-Coupled Receptors by Receptor Kinases and Arrestins

1995
Publisher Summary This chapter discusses the regulation of G protein-coupled receptors by receptor kinases and arrestins. Signal transduction through seven-transmembrane domain or serpentine receptors, which is mediated by guanine nucleotide-binding (G) proteins, accounts for a significant fraction of all signaling in the body.
R, Sterne-Marr, J L, Benovic
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G Protein-Coupled Receptor Kinases and Hypertension

High Blood Pressure & Cardiovascular Prevention, 2006
The understanding of molecular mechanisms of complex physiological phenomena, such as cardiac contractile function or blood pressure homeostasis, has generated the need for a new generation of scientists who must be able to conjugate intrinsic biological mechanisms and clinical manifestations of disease.
Iaccarino G., Campanile A., Santulli G., Zuppieri F., Koch W. J.   +4 more
openaire   +3 more sources

Tyrosine Kinase Receptor Transactivation Associated to G Protein- Coupled Receptors

Current Drug Targets, 2010
G protein-coupled receptors (GPCRs) comprise a large family of membrane receptors involved in signal transduction. These receptors are linked to a variety of physiological and biological processes such as regulation of neurotransmission, growth, cell differentiation and oncogenesis among others.
Vanessa, Almendro, Susana, García-Recio, Pedro, Gascón   +2 more
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Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and ß-arrestin proteins

Progress in Neurobiology, 2002
Sequestration of G protein-coupled receptors from the cell surface is a commonly observed phenomenon following agonist-stimulation. This process is now believed to be important for receptor resensitization as well as for signal transduction. Over the years, numerous studies have aimed at understanding the molecular mechanisms underlying internalization.
Audrey, Claing, Stéphane A, Laporte, Marc G, Caron, Robert J, Lefkowitz   +3 more
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Regulation of G protein-coupled receptor kinase 2

2002
Publisher Summary G protein-coupled receptor kinase 2 (GRK2) was originally termed a “β-adrenergic receptor kinase” (βARK) because it was purified as a kinase of the adrenergic β 2 receptor, and the adrenergic β 2 receptor was the only known substrate of GRK2. GRK2 is now known to phosphorylate different kinds of G protein-coupled receptors (GPCRs),
Tatsuya, Haga, Kazuko, Haga, Kimihiko, Kameyama, Hirofumi, Tsuga, Norihiro, Yoshida   +4 more
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G Protein‐Coupled Receptor Kinases

Journal of Neurochemistry, 1994
T, Haga, K, Haga, K, Kameyama
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Targeting G protein-coupled receptor kinases (GRKs) to G protein-coupled receptors.

Current opinion in endocrine and metabolic research
G protein-coupled receptors (GPCRs) interact with three protein families following agonist binding: heterotrimeric G proteins, G protein-coupled receptor kinases (GRKs) and arrestins. GRK-mediated phosphorylation of GPCRs promotes arrestin binding to uncouple the receptor from G protein, a process called desensitization, and for many GPCRs, arrestin ...
Sarah M, Sulon, Jeffrey L, Benovic
openaire   +1 more source