Results 261 to 270 of about 426,123 (306)

Selective Lipolysis by Photoactivation of Chaperone‐Mediated Autophagy Using Adipocyte Membrane‐Coated Nanoparticle in Hydrogel

Advanced Materials, EarlyView.
Adipocyte membrane‐coated nanoparticles loaded with rosiglitazone in hydrogel offer an alternative approach to conventional obesity treatments. This system selectively targets adipocytes, inducing lipolysis by activating chaperone‐mediated autophagy through mild photothermal stimulation.
Jaehyun Choi, Junho Byun, Dongyoon Kim, Qiaoyun Li, Dongun Jin, Yeong‐jin Choi, Ho Sang Jung, Jaiwoo Lee, Yu‐Kyoung Oh   +8 more
wiley   +1 more source

Small-Molecule G Protein-Coupled Receptor Kinase Inhibitors Attenuate G Protein-Coupled Receptor Kinase 2-Mediated Desensitization of Vasoconstrictor-Induced Arterial Contractions. [PDF]

Mol Pharmacol, 2018
Rainbow RD, Brennan S, Jackson R, Beech AJ, Bengreed A, Waldschmidt HV, Tesmer JJG, Challiss RAJ, Willets JM.   +8 more
europepmc   +1 more source

DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications

Advanced Materials, EarlyView.
DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding, Bing Liu, Andreas Peil, Sisi Fan, Jie Chao, Na Liu   +5 more
wiley   +1 more source

Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors. [PDF]

ACS Med Chem Lett, 2019
Rowlands RA, Cato MC, Waldschmidt HV, Bouley RA, Chen Q, Avramova L, Larsen SD, Tesmer JJG, White AD.   +8 more
europepmc   +1 more source

Interactions Between Active Matters and Endogenous Fields

Advanced Materials, EarlyView.
This review synthesizes endogenous field information and computational methods in contexts such as cancer, wounds, and biofilms. It organizes NAMs and AAMs by sensing, transmitting, and executing functions, compares their limitations, and from these contrasts proposes design strategies for next‐generation AAMs, offering perspectives to foster ...
Jinwei Lin, Qiaoxin Guan, Jiangqi Feng, Shuqin Chen, Leilei Xu, Jianguo Guan, Samuel Sánchez   +6 more
wiley   +1 more source

Peer Review #1 of "Molecular characterization of G-protein-coupled receptor (GPCR) and protein kinase A (PKA) cDNA in Perinereis aibuhitensis and expression during benzo(a)pyrene exposure (v0.1)"

, 2019
Huang Yi, Jia Sun, Ping Han, Heling Zhao, Mengting Wang, Zhou Yibing, Yang Dazuo, Huan Zhao   +7 more
openalex   +1 more source

Wireless Acousto‐Piezoelectric Conduit with Aligned Nanofibers for Neural Regeneration

Advanced Materials, EarlyView.
An ultrasound‐driven, highly aligned piezoelectric nanofiber‐based nerve guidance conduit (APNF‐NGC) designed for effective peripheral nerve repair has been demonstrated in this study. Featuring aligned topology, cell‐adhesive surfaces, and an axial electric field, the APNF‐NGC collectively promotes significant nerve regeneration.
Sera Jeon, Dabin Kim, Min‐Young Jo, Chae‐Min Ryu, Daniel Sanghyun Cho, Byung‐Ok Choi, Jae Kwang Kim, Miso Kim, Sang‐Woo Kim   +8 more
wiley   +1 more source

LDI, A Lipid Droplet Inhibitor, Disrupts Lipid Accumulation and Modulates Hepatic Lipid Profiles in Fatty Liver

Advanced Materials, EarlyView.
The lipid droplet inhibitor (LDI), templated with large‐pore mesoporous silica and functionalized with PKCα C1A and lipase, targets lipid degradation in fatty liver. The LDI maintains stable association with lipid droplets, thereby suppressing their formation and expansion.
Seunghee Kim, Yeojin Kim, Sanjita Paudel, In Young Kang, Suyeon Kim, Jeesoo Kim, Sunmi Park, Seung‐Hoi Koo, Hyun Sung Kim, Dae Won Jun, Jinyoung Park, Hyunbeom Lee, Joonseok Lee   +12 more
wiley   +1 more source

Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4

, 2015
Samantha J. Allen, Gopal Parthasarathy, Paul L. Darke, Ronald E. Diehl, Rachael E. Ford, Dawn L. Hall, S.A. Johnson, John C. Reid, Keith Rickert, Jennifer M. Shipman, S.M. Soisson, Paul Zuck, Sanjeev Munshi, Kevin J. Lumb   +13 more
openalex   +1 more source