Results 21 to 30 of about 427,218 (207)

G protein-coupled receptor kinase 2 promotes cardiac hypertrophy.

PLoS ONE, 2017
The increase in protein activity and upregulation of G-protein coupled receptor kinase 2 (GRK2) is a hallmark of cardiac stress and heart failure. Inhibition of GRK2 improved cardiac function and survival and diminished cardiac remodeling in various ...
Philipp Schlegel, Julia Reinkober, Eric Meinhardt, Henrike Tscheschner, Erhe Gao, Sarah M Schumacher, Ancai Yuan, Johannes Backs, Patrick Most, Thomas Wieland, Walter J Koch, Hugo A Katus, Philip W Raake   +12 more
doaj   +1 more source

G Protein Coupled Receptor Kinase 3 Regulates Breast Cancer Migration, Invasion, and Metastasis. [PDF]

PLoS ONE, 2016
Triple negative breast cancer (TNBC) is a heterogeneous disease that has a poor prognosis and limited treatment options. Chemokine receptor interactions are important modulators of breast cancer metastasis; however, it is now recognized that quantitative
Matthew J Billard, David J Fitzhugh, Joel S Parker, Jaime M Brozowski, Marcus W McGinnis, Roman G Timoshchenko, D Stephen Serafin, Ruth Lininger, Nancy Klauber-Demore, Gary Sahagian, Young K Truong, Maria F Sassano, Jonathan S Serody, Teresa K Tarrant   +13 more
doaj   +1 more source

A G protein-gated K channel is activated via beta 2-adrenergic receptors and G beta gamma subunits in Xenopus oocytes [PDF]

, 1995
In many tissues, inwardly rectifying K channels are coupled to seven- helix receptors via the Gi/Go family of heterotrimeric G proteins. This activation proceeds at least partially via G beta gamma subunits.
Dascal, Nathan, Davidson, Norman, Labarca, Cesar, Lester, Henry A., Lim, Nancy Fidler   +4 more
core   +2 more sources

Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle. [PDF]

, 2020
In vascular smooth muscle cells (VMSCs), the stimulation of store-operated channels (SOCs) mediate Ca2+ influx pathways which regulate important cellular functions including contraction, proliferation, migration, and growth that are associated with the ...
Albert, AP, Baudel, MASM-A, Large, WA, Shi, J   +3 more
core   +1 more source

GIT1 protects against breast cancer growth through negative regulation of Notch

Nature Communications, 2022
Notch signalling is reported to be hyperactivated in oestrogen receptor-negative (ER-) breast cancer. Here the authors show that G protein-coupled receptor kinase-interacting protein 1 (GIT1) negatively regulates Notch signalling and tumour growth in ER-
Songbai Zhang, Ayako Miyakawa, Malin Wickström, Cecilia Dyberg, Lauri Louhivuori, Manuel Varas-Godoy, Kati Kemppainen, Shigeaki Kanatani, Dagmara Kaczynska, Ivar Dehnisch Ellström, Lotta Elfman, Pauliina Kronqvist, Heli Repo, Katsuhiko Mikoshiba, Cecilia Sahlgren, John Inge Johnsen, Per Uhlén   +16 more
doaj   +1 more source

G-protein-coupled receptor kinase 5 polymorphism and Takotsubo cardiomyopathy. [PDF]

, 2015
BACKGROUND: Takotsubo cardiomyopathy (TTC) is an increasingly reported clinical syndrome that mimics acute myocardial infarction without obstructive coronary artery disease and is characterized by transient systolic dysfunction of the apical and/or ...
Arvigo, L, ASSENNATO, Pasquale, Bova, M, Evola, S, Giambanco, F, Giambanco, S, Guglielmo, M, LIO, Domenico, NOVO, Giuseppina, NOVO, Salvatore, Sutera, MR, VACCARINO, Loredana   +11 more
core   +1 more source

Regulation Role of Non-Rhodopsin G Protein-coupled Receptor Kinases on Tumor

Zhongliu Fangzhi Yanjiu, 2019
G protein-coupled receptor kinases (GRKs) are involved in a wide range of cellular physiology and pathological activities by specifically phosphorylating activated G-protein coupled receptors (GPCRs) to terminate GPCR signaling and phosphorylating non ...
LI Ruirui, JIANG Xiaoshan
doaj   +1 more source

G Protein-Coupled Estrogen Receptor: Rapid Effects on Hippocampal-Dependent Spatial Memory and Synaptic Plasticity

Frontiers in Endocrinology, 2020
In the hippocampus, estrogen regulates gene transcription linked to neuronal growth, neuroprotection, and the maintenance of memory function (1–3). The mechanism is likely to involve genomic regulation through classic estrogen receptor (ER) signaling ...
Ashok Kumar, Thomas C. Foster
doaj   +1 more source

G Protein-Coupled Receptor Kinase 4 [PDF]

Hypertension, 2015
The kidney plays an important role in the long-term control of blood pressure and is the major organ involved in the regulation of sodium homeostasis.1 The inappropriate sodium retention in hypertension results from enhanced renal sodium transport per se or a failure to respond appropriately to signals that decrease renal sodium transport in the face ...
Jian, Yang, Van Anthony M, Villar, John E, Jones, Pedro A, Jose, Chunyu, Zeng   +4 more
openaire   +2 more sources

Reciprocal regulation of PKA and rac signaling [PDF]

, 2013
Activated G protein-coupled receptors (GPCRs) and receptor tyrosine kinases relay extracellular signals through spatial and temporal controlled kinase and GTPase entities.
A. Riml, Baillie, Bhola, Birukova, Cook, Cuevas, Daaka, Delcourt, Dewire, Dorsam, Dumaz, E. Stefan, Eblen, G. S. Baillie, Gerits, Gloerich, Hafner, Hoffmann, Howe, Jaffe, K. R. Liedl, Kinderman, King, Kraynov, Kumar, Ligr, Malbon, Manser, Molli, Nika, Pierce, R. G. Huber, Sahai, Sch  fer, Scott, Smith, Stefan, Stork, T. Valovka, Taylor, Thaker, V. A. Bachmann, Wang, Wennerberg, Wong, Zenke, Zhang, Zhao   +47 more
core   +1 more source