Results 21 to 30 of about 522,827 (307)

G Protein-Coupled Estrogen Receptor: Rapid Effects on Hippocampal-Dependent Spatial Memory and Synaptic Plasticity

Frontiers in Endocrinology, 2020
In the hippocampus, estrogen regulates gene transcription linked to neuronal growth, neuroprotection, and the maintenance of memory function (1–3). The mechanism is likely to involve genomic regulation through classic estrogen receptor (ER) signaling ...
Ashok Kumar, Thomas C. Foster
doaj   +1 more source

Reciprocal regulation of PKA and rac signaling [PDF]

, 2013
Activated G protein-coupled receptors (GPCRs) and receptor tyrosine kinases relay extracellular signals through spatial and temporal controlled kinase and GTPase entities.
A. Riml, Baillie, Bhola, Birukova, Cook, Cuevas, Daaka, Delcourt, Dewire, Dorsam, Dumaz, E. Stefan, Eblen, G. S. Baillie, Gerits, Gloerich, Hafner, Hoffmann, Howe, Jaffe, K. R. Liedl, Kinderman, King, Kraynov, Kumar, Ligr, Malbon, Manser, Molli, Nika, Pierce, R. G. Huber, Sahai, Sch  fer, Scott, Smith, Stefan, Stork, T. Valovka, Taylor, Thaker, V. A. Bachmann, Wang, Wennerberg, Wong, Zenke, Zhang, Zhao   +47 more
core   +1 more source

G Protein-Coupled Receptor Kinase 2 (GRK2) as a Potential Therapeutic Target in Cardiovascular and Metabolic Diseases

Frontiers in Pharmacology, 2019
G protein-coupled receptor kinase 2 (GRK2) is a central signaling node involved in the modulation of many G protein-coupled receptors (GPCRs) and also displaying regulatory functions in other cell signaling routes.
C. Murga, Alba C. Arcones, Marta Cruces-Sande, A. Briones, M. Salaices, Federico Mayor, Jr.   +5 more
semanticscholar   +1 more source

Comparison of MEK/ERK pathway inhibitors on the upregulation of vascular G-protein coupled receptors in rat cerebral arteries [PDF]

, 2010
Organ culture is an in vitro method for investigating cellular mechanisms involved in upregulation of vasocontractile G-protein coupled receptors. We hypothesize that mitogen-activated-protein kinase (MEK) and/or extracellular-signal-regulated kinase ...
Ansar, S., Edvinsson, L., Sandhu, Hardip
core   +1 more source

Selective Regulation of Gαq/11 by an RGS Domain in the G Protein-coupled Receptor Kinase, GRK2*

Journal of Biological Chemistry, 1999
G protein-coupled receptor kinases (GRKs) are well characterized regulators of G protein-coupled receptors, whereas regulators of G protein signaling (RGS) proteins directly control the activity of G protein α subunits.
C. Carman, J. Parent, P. Day, A. Pronin, P. M. Sternweis, P. Wedegaertner, A. Gilman, J. Benovic, T. Kozasa   +8 more
semanticscholar   +1 more source

G-protein-coupled receptor kinase 5 polymorphism and Takotsubo cardiomyopathy. [PDF]

, 2015
BACKGROUND: Takotsubo cardiomyopathy (TTC) is an increasingly reported clinical syndrome that mimics acute myocardial infarction without obstructive coronary artery disease and is characterized by transient systolic dysfunction of the apical and/or ...
Arvigo, L, ASSENNATO, Pasquale, Bova, M, Evola, S, Giambanco, F, Giambanco, S, Guglielmo, M, LIO, Domenico, NOVO, Giuseppina, NOVO, Salvatore, Sutera, MR, VACCARINO, Loredana   +11 more
core   +1 more source

Disentangling bias between Gq, GRK2, and arrestin3 recruitment to the M3 muscarinic acetylcholine receptor

eLife, 2021
G protein-coupled receptors (GPCRs) transmit extracellular signals to the inside by activation of intracellular effector proteins. Different agonists can promote differential receptor-induced signaling responses – termed bias – potentially by eliciting ...
Anja Flöser, Katharina Becker, Evi Kostenis, Gabriele König, Cornelius Krasel, Peter Kolb, Moritz Bünemann   +6 more
doaj   +1 more source

Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell. [PDF]

, 2018
G protein-coupled receptors (GPCRs) transduce pleiotropic intracellular signals in a broad range of physiological responses and disease states. Activated GPCRs can undergo agonist-induced phosphorylation by G protein receptor kinases (GRKs) and second ...
Chowdhury, Dhrubajyoti, Deng, Yawen, Hell, Johannes W, Navedo, Manuel F, Nieves-Cintron, Madeline, Qi, Jinyi, Shen, Ao, Shi, Qian, Xiang, Yang K   +8 more
core   +3 more sources

Agonist-induced internalization and desensitization of the apelin receptor [PDF]

, 2016
Apelin acts via the G protein-coupled apelin receptor (APJ) to mediate effects on cardiovascular and fluid homeostasis. G protein-coupled receptor (GPCR) trafficking has an important role in the regulation of receptor signalling pathways and cellular ...
Lolait, Stephen J., McArdle, Craig A., O'Carroll, Anne-Marie, Pope, George R., Tilve, Sharada   +4 more
core   +2 more sources

Ginsenoside Rg1 activates ligand-independent estrogenic effects via rapid estrogen receptor signaling pathway

Journal of Ginseng Research, 2019
Background: Ginsenoside Rg1 was shown to exert ligand-independent activation of estrogen receptor (ER) via mitogen-activated protein kinase–mediated pathway.
Quan-Gui Gao, Li-Ping Zhou, Vien Hoi-Yi Lee, Hoi-Yi Chan, Cornelia Wing-Yin Man, Man-Sau Wong   +5 more
doaj   +1 more source