Results 41 to 50 of about 396,098 (353)

Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. [PDF]

, 2009
Activation of Hedgehog (Hh) signaling requires the transmembrane protein Smoothened (Smo), a member of the G-protein coupled receptor superfamily. In mammals, Smo translocates to the primary cilium upon binding of Hh ligands to their receptor, Patched ...
Chen, Miao-Hsueh, Chuang, Pao-Tien, Wilson, Christopher W   +2 more
core   +3 more sources

PKA regulatory subunits mediate synergy among conserved G-protein-coupled receptor cascades [PDF]

, 2011
G-protein-coupled receptors sense extracellular chemical or physical stimuli and transmit these signals to distinct trimeric G-proteins. Activated Gα-proteins route signals to interconnected effector cascades, thus regulating thresholds, amplitudes and ...
A Arnsten, A Levchenko, B Moepps, B Nyfeler, C Gales, C Parent, CC Malbon, CW Dessauer, DA Walsh, E Rozengurt, E Stefan, ER Kandel, FD Smith, G Griffioen, G Pineyro, GH Nguyen, H Tamaki, I Remy, J Lyons, J Wu, JD Hildebrandt, JD Scott, JG Baker, JL Hartman, JM Canaves, KL Dodge-Kafka, KL Eckel-Mahan, KL Pierce, L Birnbaumer, L Bobrovskaya, L Lignitto, M Freissmuth, M Leduc, MC Theodoropoulou, MK Malleshaiah, N Barkai, N Gerits, N Kannan, O Brandman, P François, PH Ear, PJ Stork, Q Ni, R Lappano, R Wetzker, RJ Lefkowitz, RK Sunahara, RT Dorsam, SK Ogden, SM Pontier, SR Neves, SS Taylor, T Jin, TM Yi, W Wong, Y Daaka, Y Huang, Z Farfel, ZG Goldsmith   +58 more
core   +2 more sources

Functional analysis of a human A1 adenosine receptor/green fluorescent protein/Gi1α fusion protein following stable expression in CHO cells [PDF]

, 1999
Fusion proteins between the human A1 adenosine receptor and the pertussis toxin resistant (Cys351Gly) mutant of the G-protein α subunit Gi1α (A1/Gi), and between the human A1 adenosine receptor, the Aequorea victoria green fluorescent protein (GFP) and ...
Bevan, Nicola, Coote, Jim, Drmota, Tomas, Milligan, Graeme, Palmer, Tim, Rees, Stephen, Wise, Alan   +6 more
core   +1 more source

GRKs as Modulators of Neurotransmitter Receptors

Cells, 2020
Many receptors for neurotransmitters, such as dopamine, norepinephrine, acetylcholine, and neuropeptides, belong to the superfamily of G protein-coupled receptors (GPCRs). A general model posits that GPCRs undergo two-step homologous desensitization: the
Eugenia V. Gurevich, Vsevolod V. Gurevich   +1 more
doaj   +1 more source

Csk, a Critical Link of G Protein Signals to Actin Cytoskeletal Reorganization [PDF]

, 2002
Heterotrimeric G proteins can signal to reorganize the actin cytoskeleton, but the mechanism is unclear. Here we report that, in tyrosine kinase Csk-deficient mouse embryonic fibroblast cells, G protein (Gβγ, Gα12, Gα13, and Gαq)-induced, and G protein ...
Ali, Shariq, Cole, Philip A., Huang, Jianyun, Huang, Xin-Yun, Lowry, William E., Ma, Yong-Chao, Okada, Masato, Wang, Dongxia, Williams, Daniel M.   +8 more
core   +1 more source

Ligand-induced dynamics of heterotrimeric G protein-coupled receptor-like kinase complexes.

PLoS ONE, 2017
BackgroundArabidopsis, 7-transmembrane Regulator of G signaling protein 1 (AtRGS1) modulates canonical G protein signaling by promoting the inactive state of heterotrimeric G protein complex on the plasma membrane.
Meral Tunc-Ozdemir, Alan M Jones
doaj   +1 more source

Yeast Ste2 receptors as tools for study of mammalian protein kinases and adaptors involved in receptor trafficking [PDF]

, 2006
BACKGROUND: Mammalian receptors that couple to effectors via heterotrimeric G proteins (e.g., beta (2)-adrenergic receptors) and receptors with intrinsic tyrosine kinase activity (e.g., insulin and IGF-I receptors) constitute the proximal points of two ...
Malbon, Craig C, Shumay, Elena, Wang, Hsien-yu, Yin, Dezhong   +3 more
core   +2 more sources

The Origin and Evolution of G Protein-Coupled Receptor Kinases

PLoS ONE, 2012
G protein-coupled receptor (GPCR) kinases (GRKs) play key role in homologous desensitization of GPCRs. GRKs phosphorylate activated receptors, promoting high affinity binding of arrestins, which precludes G protein coupling. Direct binding to active GPCRs activates GRKs, so that they selectively phosphorylate only the activated form of the receptor ...
Vsevolod V. Gurevich, Eugenia V. Gurevich, Arcady Mushegian   +2 more
openaire   +5 more sources

A G protein-gated K channel is activated via beta 2-adrenergic receptors and G beta gamma subunits in Xenopus oocytes [PDF]

, 1995
In many tissues, inwardly rectifying K channels are coupled to seven- helix receptors via the Gi/Go family of heterotrimeric G proteins. This activation proceeds at least partially via G beta gamma subunits.
Dascal, Nathan, Davidson, Norman, Labarca, Cesar, Lester, Henry A., Lim, Nancy Fidler   +4 more
core   +2 more sources

Regulation of G Protein-coupled Receptor Kinases by Caveolin [PDF]

Journal of Biological Chemistry, 1999
G protein-coupled receptor kinases (GRKs) have been principally characterized by their ability to phosphorylate and desensitize G protein-coupled receptors. However, recent studies suggest that GRKs may have more diverse protein/protein interactions in cells.
Michael P. Lisanti, Jeffrey L. Benovic, Christopher V. Carman   +2 more
openaire   +3 more sources