Results 51 to 60 of about 246,187 (261)

NMDA receptor regulation of levodopa-induced behavior and changes in striatal G protein-coupled receptor kinase 6 and ß-arrestin-1 expression in parkinsonian rats

Clinical Interventions in Aging, 2013
Na Wu, Lu Song, Xinxin Yang, Weien Yuan, Zhenguo Liu Department of Neurology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China Background: Parkinson’s disease is a neurodegenerative ...
Wu N, Song L, Yang X, Yuan W, Liu Z
doaj  

Insulin signaling inhibits the 5-HT_2C receptor in choroid plexus via MAP kinase

BMC Neuroscience, 2003
Background G protein-coupled receptors (GPCRs) interact with heterotrimeric GTP-binding proteins (G proteins) to modulate acute changes in intracellular messenger levels and ion channel activity.
Guan Kunliang, DePaoli-Roach Anna A, Marshall Mark S, Bye Leighan S, Zhang Shengwen, Hurley Joyce H, Fox Aaron P, Yu Lei   +7 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

The RAF Kinase Inhibitor Protein (RKIP): Good as Tumour Suppressor, Bad for the Heart

Cells, 2022
The RAF kinase inhibitor protein, RKIP, is a dual inhibitor of the RAF1 kinase and the G protein-coupled receptor kinase 2, GRK2. By inhibition of the RAF1-MAPK (mitogen-activated protein kinase) pathway, RKIP acts as a beneficial tumour suppressor.
Joshua Abd Alla, Ursula Quitterer
doaj   +1 more source

Peptide substrates for G protein‐coupled receptor kinase 2 [PDF]

FEBS Letters, 2014
G protein‐coupled receptor kinases (GRKs) control the signaling and activation of G protein‐coupled receptors through phosphorylation. In this study, consensus substrate motifs for GRK2 were identified from the sequences of GRK2 protein substrates, and 17 candidate peptides were synthesized to identify peptide substrates with high affinity for GRK2 ...
Asai, Daisuke, Toita, Riki, Murata, Masaharu, Katayama, Yoshiki, Nakashima, Hideki, Kang, Jeong-Hun   +5 more
openaire   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Beyond cAMP: The Regulation of Akt and GSK3 by Dopamine Receptors

Frontiers in Molecular Neuroscience, 2011
Brain dopamine receptors have been prefered targets for numerous pharmacological compounds developed for the treatment of various neuropsychiatric disorders.
Jean-Martin eBeaulieu, Thomas eDel' Guidice, Tatiana eSotnikova, Morgane eLemasson, Raul eGainetdinov   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Aldosterone Jeopardizes Myocardial Insulin and β-Adrenergic Receptor Signaling via G Protein-Coupled Receptor Kinase 2

Frontiers in Pharmacology, 2019
Hyperaldosteronism alters cardiac function, inducing adverse left ventricle (LV) remodeling either via increased fibrosis deposition, mitochondrial dysfunction, or both.
Alessandro Cannavo, Alessandro Cannavo, Federica Marzano, Andrea Elia, Daniela Liccardo, Leonardo Bencivenga, Giuseppina Gambino, Claudia Perna, Antonio Rapacciuolo, Antonio Cittadini, Nicola Ferrara, Nicola Ferrara, Nazareno Paolocci, Nazareno Paolocci, Walter J. Koch, Giuseppe Rengo, Giuseppe Rengo   +16 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source