Results 61 to 70 of about 536,609 (348)

Agonist-induced internalization and desensitization of the apelin receptor [PDF]

, 2016
Apelin acts via the G protein-coupled apelin receptor (APJ) to mediate effects on cardiovascular and fluid homeostasis. G protein-coupled receptor (GPCR) trafficking has an important role in the regulation of receptor signalling pathways and cellular ...
Lolait, Stephen J., McArdle, Craig A., O'Carroll, Anne-Marie, Pope, George R., Tilve, Sharada   +4 more
core   +2 more sources

Regulation of G Protein-coupled Receptor Kinases by Caveolin [PDF]

Journal of Biological Chemistry, 1999
G protein-coupled receptor kinases (GRKs) have been principally characterized by their ability to phosphorylate and desensitize G protein-coupled receptors. However, recent studies suggest that GRKs may have more diverse protein/protein interactions in cells.
C V, Carman, M P, Lisanti, J L, Benovic
openaire   +2 more sources

Phosphatidylinositol 4,5-Bisphosphate (PIP2)-enhanced G Protein-coupled Receptor Kinase (GRK) Activity: LOCATION, STRUCTURE, AND REGULATION OF THE PIP2 BINDING SITE DISTINGUISHES THE GRK SUBFAMILIES*

Journal of Biological Chemistry, 1996
The G protein-coupled receptor kinases (GRKs) phosphorylate agonist occupied G protein-coupled receptors and play an important role in mediating receptor desensitization.
J. Pitcher, Z. Fredericks, W. C. Stone, R. Premont, R. Stoffel, W. Koch, R. Lefkowitz   +6 more
semanticscholar   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Caveolae-Independent Activation of Protein Kinase A in Rat Neonatal Myocytes

Journal of Pharmacological Sciences, 2005
Cardiomyocytes express both β1- and β2-adrenergic receptors, and these receptors play a differential role in chronotropic and inotropic effects of the heart. Caveolae are known as an important regulator of G-protein-coupled receptor signaling.
Masashi Fukutomi, Motohiro Nishida, Yoshiko Maruyama, Hiroyuki Kobayashi, Hitoshi Kurose   +4 more
doaj   +1 more source

Endothelial APC/PAR1 distinctly regulates cytokine-induced pro-inflammatory VCAM-1 expression

Frontiers in Molecular Biosciences, 2023
Introduction: Dysfunction of the endothelium impairs its’ protective role and promotes inflammation and progression of vascular diseases. Activated Protein C (APC) elicits endothelial cytoprotective responses including barrier stabilization, anti ...
Cierra A. Birch, Helen Wedegaertner, Helen Wedegaertner, Lennis B. Orduña-Castillo, Monica L. Gonzalez Ramirez, Huaping Qin, JoAnn Trejo   +6 more
doaj   +1 more source

The Basal Thermal Sensitivity of the TRPV1 Ion Channel Is Determined by PKCβII [PDF]

, 2014
Copyright © 2014 the authors 0270-6474/14/348246-13$15.00/0.Peer reviewedPublisher ...
Hasan, Raquibul, Li, Lin, Zhang, Xuming
core   +1 more source

G Protein-Coupled Receptor Kinases Take Central Stage

Cells, 2022
The relevance of the family of G protein-coupled receptor kinases (GRKs) is based on its key participation in the regulation and intracellular dynamics of the largest family of membrane receptors, namely G protein-coupled receptors (GPCRs) [...]
Federico Mayor, Cristina Murga
openaire   +6 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

l-DOPA reverses the MPTP-induced elevation of the arrestin2 and GRK6 expression and enhanced ERK activation in monkey brain

Neurobiology of Disease, 2005
Dysregulation of dopamine receptors (DARs) is believed to contribute to Parkinson disease (PD) pathology. G protein-coupled receptors (GPCR) undergo desensitization via activation-dependent phosphorylation by G protein-coupled receptor kinases (GRKs ...
E. Bezard, C.E. Gross, Li Qin, V.V. Gurevich, J.L. Benovic, E.V. Gurevich   +5 more
doaj   +1 more source