Results 161 to 170 of about 425,489 (192)
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G-Protein-Coupled Receptor Kinase 2 and Hypertension
High Blood Pressure & Cardiovascular Prevention, 2013Numerous factors partake in the fine-tuning of arterial blood pressure. The heptahelical G-protein-coupled receptors (GPCRs) represent one of the largest classes of cell-surface receptors. Further, ligands directed at GPCRs account for nearly 30 % of current clinical pharmaceutical agents available.
SANTULLI, GAETANO +2 more
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G protein-coupled receptor kinase 2 (GRK2): mechanisms of regulation and physiological functions [PDF]
FEBS Letters, 1998 G protein‐coupled receptor kinase 2 (GRK2) plays a key role in determining the rate and extent of G protein‐coupled receptor (GPCR) desensitization and resensitization. Recent data indicate that GRK2 activity, subcellular distribution and expression are tightly regulated.
Anna M Aragay, Federico Mayor
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A role for G protein‐coupled receptor kinase 2 in mechanical allodynia
European Journal of Neuroscience, 2007AbstractInflammation and nerve injury can both induce mechanical allodynia via mechanisms involving the production of pro‐inflammatory cytokines and increased neuronal activity. Many neurotransmitters involved in pain signal via G protein‐coupled receptors (GPCRs).
Wendy, Kleibeuker +7 more
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G protein-coupled receptor kinase 2 (GRK2) in migration and inflammation
Archives of Physiology and Biochemistry, 2008G protein-coupled receptor kinase 2 (GRK2) is a key modulator of G protein-coupled receptors and other plasma membrane receptors stimulated by chemotactic messengers. On top of that, GRK2 has been reported to interact with a variety of signal transduction proteins related to cell migration such as MEK, Akt, PI3Kgamma or GIT.
Petronila, Penela +7 more
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Extracellular signal-regulated kinases control expression of G protein-coupled receptor kinase 2 (GRK2) [PDF]
FEBS Letters, 2002 G protein‐coupled receptor kinase 2 (GRK2) phosphorylates G protein‐coupled receptors resulting in uncoupling from G proteins. Receptors modulate GRK2 expression, however the mechanistic basis for this effect is largely unknown. Here we report a novel mechanism by which receptors use the extracellular signal‐regulated kinase (ERK) cascade to regulate ...
Juliane Theilade
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G Protein-Coupled Receptor Kinase 2 in Patients With Acute Myocardial Infarction
The American Journal of Cardiology, 2011Lymphocyte G protein-coupled receptor kinase 2 (GRK2) levels are increased in patients with chronic heart failure, and in this condition, they correlate with cardiac function. The aim of this study was to assess the prognostic role of GRK2 during acute cardiac dysfunction in humans.
SANTULLI, GAETANO +6 more
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MAP kinase protects G protein-coupled receptor kinase 2 from proteasomal degradation
Biochemical and Biophysical Research Communications, 2005The G protein-coupled receptor kinase 2 (GRK2) phosphorylates and shuts down signaling from 7-transmembrane receptors (7TMs). Although, receptor activity controls GRK2 expression levels, the underlying molecular mechanisms are poorly understood. We have previously shown that extracellular signal-regulated kinase (ERK1/2) activation increases GRK2 ...
Juliane, Theilade +3 more
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Role of G Protein–Coupled Receptor Kinase 2 and Arrestins in β-Adrenergic Receptor Internalization
Trends in Cardiovascular Medicine, 1998G protein-coupled receptors (GPCRs) mediate the action of messengers that are key modulators of the function, growth, and differentiation of cardiac and vascular cells. A general feature of GPCRs is the existence of complex regulatory mechanisms that modulate receptor responsiveness and underlie important physiologic phenomena such as signal ...
F, Mayor, P, Penela, A, Ruiz-Gómez
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Opioid Receptor Types Selectively Cointernalize with G Protein-Coupled Receptor Kinases 2 and 3
The Journal of Pharmacology and Experimental Therapeutics, 2002Activation of G protein-coupled receptors (GPCRs) may bring about their disappearance from the cell membrane, and it is commonly accepted that G protein-coupled receptor kinases (GRKs) play a key function in this mechanism. Opioid receptors belong to the family of GPCRs and are substrates of GRKs.
Rüdiger, Schulz +2 more
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β2-Adrenergic receptors and G-protein-coupled receptor kinase 2 in rabbit pleural mesothelium
Respiratory Physiology & Neurobiology, 2010Former studies on net rate of liquid absorption from small Ringer or 1% albumin-Ringer hydrothoraces in rabbits indicated that Na+ transport and solute-coupled liquid absorption by mesothelium is increased by pleural liquid dilution, and stimulation of β2-adrenoreceptors (β2AR).
C. Sironi +5 more
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