Desensitization of G protein-coupled receptors and neuronal functions.
Annual Review of Neuroscience, 2004 G protein-coupled receptors (GPCRs) have proven to be the most highly favorable class of drug targets in modern pharmacology. Over 90% of nonsensory GPCRs are expressed in the brain, where they play important roles in numerous neuronal functions.
R. Gainetdinov +4 more
semanticscholar +1 more source
Gain of function mutants: Ion channels and G protein-coupled receptors [PDF]
, 2000 Many ion channels and receptors display striking phenotypes for gain-of-function mutations but milder phenotypes for null mutations. Gain of molecular function can have several mechanistic bases: selectivity changes, gating changes including constitutive
Karschin, Andreas, Lester, Henry A.
core +1 more source
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, Volume 599, Issue 8, Page 1094-1112, April 2025.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
G protein-coupled receptors: the evolution of structural insight
AIMS Biophysics, 2017 G protein-coupled receptors (GPCR) comprise a diverse superfamily of over 800 proteins that have gained relevance as biological targets for pharmaceutical drug design.
Samantha B. Gacasan +2 more
doaj +1 more source
The mutational landscape of human olfactory G protein-coupled receptors
BMC Biology, 2021 Background Olfactory receptors (ORs) constitute a large family of sensory proteins that enable us to recognize a wide range of chemical volatiles in the environment.
Ramón Cierco Jimenez +6 more
doaj +1 more source
A universal lower bound on the free energy cost of molecular measurements [PDF]
Phys. Rev. E 95, 062410 (2017), 2016 The living cell uses a variety of molecular receptors to read and process chemical signals that vary in space and time. We model the dynamics of such molecular level measurements as Markov processes in steady state, with a coupling between the receptor and the signal. We prove exactly that, when the the signal dynamics is not perturbed by the receptors,
arxiv +1 more source
Cloning, characterization and expression of a G-protein-coupled receptor from Lymnaea stagnalis and identification of a leucokinin-like peptide, PSFHSWS amide as its endogenous ligand. [PDF]
, 1997 Neuropeptides are known to be important signaling molecules in several neural systems of the pond snailLymnaea stagnalis. Although the functions of these peptides have been studied in many neurons, the nature of the postsynaptic signal transduction is ...
Burke, J.F. +7 more
core +6 more sources
FEBS Letters, EarlyView.LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra +7 more
wiley +1 more source
Structure and dynamics of dynorphin peptide and its receptor [PDF]
arXiv, 2019 Dynorphin is a neuropeptide involved in pain, addiction and mood regulation. It exerts its activity by binding to the kappa opioid receptor (KOP) which belongs to the large family of G-protein coupled receptors. The dynorphin peptide was discovered in 1975, while its receptor was cloned in 1993.
arxiv
The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis [PDF]
, 2009 Platelets play a fundamental role in hemostasis and thrombosis. They are also involved in pathologic conditions resulting from blocked blood vessels, including myocardial infarction and ischemic stroke.
Abtahian +79 more
core +2 more sources