Results 291 to 300 of about 818,382 (379)

Adhesion G Protein-Coupled Receptors as Drug Targets.

Annual Review of Pharmacology and Toxicology, 2018

semanticscholar   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Targeting G-protein-coupled receptors and gut microbiota: Ge-Lian Qi-Shen decoction elevates GLP-1 to combat non-alcoholic fatty liver disease. [PDF]

Chin Med
Ding M, Xiao Z, Hou X, Luo Z, Zhang Z, Guo M, Xu C, Xu R, Shan J, Peng H.   +9 more
europepmc   +1 more source

Pathway and mechanism of drug binding to G-protein-coupled receptors

Proceedings of the National Academy of Sciences of the United States of America, 2011
R. Dror, Albert C. Pan, Daniel H Arlow, D. Borhani, P. Maragakis, Yibing Shan, Huafeng Xu, D. Shaw   +7 more
semanticscholar   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Mechanisms of Peptide Agonist Dissociation and Deactivation of Adhesion G-Protein-Coupled Receptors. [PDF]

Biochemistry
Joshi K, Miao Y.
europepmc   +1 more source

G-protein coupled receptors [PDF]

Journal of Vascular Surgery, 2001
openaire   +1 more source

Serial Femtosecond Crystallography of G Protein-Coupled Receptors.

Annual Review of Biophysics, 2018
B. Stauch, V. Cherezov
semanticscholar   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Astrocytic G Protein-Coupled Receptors in Drug Addiction. [PDF]

Engineering (Beijing)
Zinsmaier AK, Nestler EJ, Dong Y.
europepmc   +1 more source