Results 291 to 300 of about 807,055 (385)

Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors

Cell, 2017
X. E. Zhou, Yuanzheng He, Parker W. de Waal, Xiang Gao, Yanyong Kang, N. Van Eps, Yanting Yin, K. Pal, Devrishi Goswami, Thomas A. White, A. Barty, Naomi R. Latorraca, H. Chapman, Wayne L Hubbell, R. Dror, Raymond C. Stevens, V. Cherezov, V. Gurevich, Patrick R. Griffin, Oliver P. Ernst, K. Melcher, H. E. Xu   +21 more
semanticscholar   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Supramolecular assembly of novel achatin structurally similar peptide as potential G protein-coupled receptors anticancer ligands: focus on its pseudo-macrocycle nature. [PDF]

R Soc Open Sci
Bojarska J, Breza M, Jelemenska I, Madura I, Jafari S, Kaczmarek K, Ziora Z, Wolf W.   +7 more
europepmc   +1 more source

Cytoskeletal Reorganization by G Protein-Coupled Receptors Is Dependent on Phosphoinositide 3-Kinase γ, a Rac Guanosine Exchange Factor, and Rac

, 1998
D. Alice, Ara Metjian, Shubha Bagrodia, Stephen J. Taylor, Charles S. Abrams   +4 more
openalex   +1 more source

Activation of Platelet Function Through G Protein–Coupled Receptors

Circulation Research, 2006
S. Offermanns
semanticscholar   +1 more source

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source

Extracellular ATP increases agonist potency and reduces latency at class B G protein-coupled receptors. [PDF]

Mol Pharmacol
Zhu S, Yuan A, Duffy T, Kim BH, Ozawa T, Dixon SJ, Chidiac P.   +6 more
europepmc   +1 more source

Identification of amino acids essential for angulin‐1/3 binding of the tricellular tight junction binder, angubindin‐1

FEBS Open Bio, EarlyView.
Angubindin‐1 binds angulin‐1/‐3 at tricellular tight junctions, enhancing intestinal macromolecule permeation. Alanine scanning identified six essential residues (L562, L598, E638, V640, Y643, and K644) of angubindin‐1 critical for binding to angulin‐1/‐3 and permeation‐enhancing activity, providing insights for the development of targeted noninvasive ...
Taiki Kuzu, Yumi Iwashita, Keisuke Tachibana, Itsuki Nishino, Yuki Niwa, Atsuko Uyeda, Kazuki Matsuo, Masahiro Nagahama, Masuo Kondoh   +8 more
wiley   +1 more source

Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors

Science Signaling, 2015
I. Masuho, O. Ostrovskaya, Grant M. Kramer, Christopher D. Jones, Keqiang Xie, K. Martemyanov   +5 more
semanticscholar   +1 more source

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source