Results 121 to 130 of about 3,042,012 (148)

A High-Throughput Method for Screening Peptide Activators of G-Protein-Coupled Receptors. [PDF]

ACS Omega
Paudel YP, Valiente PA, Kim J, Kim PM.
europepmc   +1 more source

Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast cells and disease models. [PDF]

Signal Transduct Target Ther
Al Hamwi G, Alnouri MW, Verdonck S, Leonczak P, Chaki S, Frischbutter S, Kolkhir P, Matthey M, Kopp C, Bednarski M, Riedel YK, Marx D, Clemens S, Namasivayam V, Gattner S, Thimm D, Sylvester K, Wolf K, Kremer AE, De Jonghe S, Wenzel D, Kotańska M, Ali H, Herdewijn P, Müller CE.   +24 more
europepmc   +1 more source

Cryo-EM Structures and AlphaFold3 Models of Histamine Receptors Reveal Diverse Ligand Binding and G Protein Bias. [PDF]

Pharmaceuticals (Basel)
Chen A, Su C, Zhang Z, Zhang H.
europepmc   +1 more source

Emerging regulators of gastric cancer angiogenesis: Synergistic effects of regulator of G protein signaling 4 and midkine.

Cytojournal
He Y, Li H, Li K, Song H.
europepmc   +1 more source

Substrate-specific regulation of mTORC1 activity by G protein-coupled receptors

Atkinson SJ, Ritchie WV, Thompson K, Thompson D, Hislop JN, Hatakeyama R.   +5 more
europepmc   +1 more source

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G proteins

Trends in Biochemical Sciences, 1992
The family of heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) serves an essential role in transducing receptor-generated signals across the plasma membrane. Recent findings reveal unexpected functional roles for individual G protein subunits.
J R, Hepler, A G, Gilman
openaire   +4 more sources

G Proteins and G Protein-Coupled Receptors [PDF]

, 2002
Cells live in a constantly changing milieu. The structure and biochemical nature of this environment is dynamic and in order for normal cellular function to proceed in a manner appropriate for the benefit of the organism, cells must be able to access this changing information.
Marc G. Caron, Michael A. Shetzline
openaire   +1 more source

Heterotrimeric G protein activation by G-protein-coupled receptors [PDF]

Nature Reviews Molecular Cell Biology, 2008
Heterotrimeric G proteins have a crucial role as molecular switches in signal transduction pathways mediated by G-protein-coupled receptors. Extracellular stimuli activate these receptors, which then catalyse GTP-GDP exchange on the G protein alpha-subunit.
William M. Oldham, Heidi E. Hamm
openaire   +2 more sources

G Protein Pathways

Science, 2002
The heterotrimeric guanine nucleotide–binding proteins (G proteins) are signal transducers that communicate signals from many hormones, neurotransmitters, chemokines, and autocrine and paracrine factors. The extracellular signals are received by members of a large superfamily of receptors with seven membrane-spanning regions that activate the G ...
Prahlad T. Ram, Susana R. Neves, Ravi Iyengar   +2 more
openaire   +3 more sources