Results 131 to 140 of about 3,042,012 (148)
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The role of G protein conformation in receptor–G protein selectivity
Nature Chemical Biology, 2023G protein-coupled receptors (GPCRs) selectively activate at least one of the four families of heterotrimeric G proteins, but the mechanism of coupling selectivity remains unclear. Structural studies emphasize structural complementarity of GPCRs and nucleotide-free G proteins, but selectivity is likely to be determined by transient intermediate-state ...
Wonjo Jang +4 more
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Current Opinion in Cell Biology, 1996
Over the past year, the thrust of work in the field of heterotrimeric G proteins has been primarily in the following areas: first, resolution of their three-dimensional structures by X-ray crystallography; second, elucidation of the effect of lipid modifications on the Galpha and Ggamma subunits; third, understanding the role of the Gbetagamma dimer in
Annette Gilchrist, Heidi E. Hamm
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Over the past year, the thrust of work in the field of heterotrimeric G proteins has been primarily in the following areas: first, resolution of their three-dimensional structures by X-ray crystallography; second, elucidation of the effect of lipid modifications on the Galpha and Ggamma subunits; third, understanding the role of the Gbetagamma dimer in
Annette Gilchrist, Heidi E. Hamm
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G Proteins and Phototransduction
Annual Review of Physiology, 2002▪ Abstract Phototransduction is the process by which a photon of light captured by a molecule of visual pigment generates an electrical response in a photoreceptor cell. Vertebrate rod phototransduction is one of the best-studied G protein signaling pathways. In this pathway the photoreceptor-specific G protein, transducin, mediates between the visual
Edward N. Pugh +2 more
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Trends in Pharmacological Sciences, 1999
Heterotrimeric G proteins couple membrane-bound heptahelical receptors to their cellular effector systems (ion channels or enzymes generating a second messenger). In current pharmacotherapy, the input to G protein-regulated signalling is typically manipulated by targeting the receptor with appropriate agonists or antagonists and, to a lesser extent, by
Elisa Bofill-Cardona +3 more
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Heterotrimeric G proteins couple membrane-bound heptahelical receptors to their cellular effector systems (ion channels or enzymes generating a second messenger). In current pharmacotherapy, the input to G protein-regulated signalling is typically manipulated by targeting the receptor with appropriate agonists or antagonists and, to a lesser extent, by
Elisa Bofill-Cardona +3 more
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G Protein-Coupled Receptors and G Proteins
2000G protein-coupled receptors (GPCRs) form a large and functionally diverse superfamily of cell membrane receptors. Many signaling cascades use GPCRs to convert a large diversity of external and internal stimuli including photons, odorants, and ions as well as hormones and neurotransmitter agonists into intracellular responses.
P. Michael Conn, Alfredo Ulloa-Aguirre
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G Protein-Coupled Receptors and G Proteins
1997G protein-coupled receptors (GPCRs) belong to a large class of membrane-spanning receptors. GPCRs function as antennae for external signals consisting of chemical ligands or photons (in the case of opsins). Once the external signal is received, it is transduced to a cytosolic G protein. Subsequently, the G protein itself becomes activated.
Gabriëlle M. Donné-Op den Kelder +2 more
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G-protein-independent signaling by G-protein-coupled receptors
Trends in Neurosciences, 2000Two classes of receptors transduce neurotransmitter signals: ionotropic receptors and heptahelical metabotropic receptors. Whereas the ionotropic receptors are structurally associated with a membrane channel, a mediating mechanism is necessary to functionally link metabotropic receptors with their respective effectors.
Heuss, C, Gerber, U
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G-Protein Subunit Dissociation Is not an Integral Part of G-Protein Action
ChemBioChem, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
Shoshana Klein, Alexander Levitzki
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New England Journal of Medicine, 1995
The award of the 1994 Nobel Prize in Physiology or Medicine to Alfred G. Gilman and Martin Rodbell for the discovery of G (guanine nucleotide–binding) proteins and their role in cellular signal tra...
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The award of the 1994 Nobel Prize in Physiology or Medicine to Alfred G. Gilman and Martin Rodbell for the discovery of G (guanine nucleotide–binding) proteins and their role in cellular signal tra...
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Nature Reviews Molecular Cell Biology, 2005
The focus of developmental biologists has expanded from the analysis of gene expression to include the analysis of cell signalling. Heterotrimeric G proteins (G proteins) mediate signalling from a superfamily of heptahelical receptors (G-protein-coupled receptors) to a smaller number of effector units that include adenylyl cyclases, phospholipase C and
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The focus of developmental biologists has expanded from the analysis of gene expression to include the analysis of cell signalling. Heterotrimeric G proteins (G proteins) mediate signalling from a superfamily of heptahelical receptors (G-protein-coupled receptors) to a smaller number of effector units that include adenylyl cyclases, phospholipase C and
openaire +2 more sources