Results 251 to 260 of about 5,882,179 (311)

G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis

, 2012
Patrick M. Giguère, Matthew J. Billard, Geneviève Laroche, Brian K. Buckley, Roman G. Timoshchenko, Marcus W. McGinnis, Denise Esserman, Oded Foreman, Peng Liu, David P. Siderovski, Teresa K. Tarrant   +10 more
openalex   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Structural insights into ligand recognition and G protein preferences across histamine receptors. [PDF]

Commun Biol
Matsuzaki Y, Sano FK, Oshima HS, Akasaka H, Kobayashi K, Tanaka T, Itoh Y, Shihoya W, Kise Y, Kusakizako T, Inoue A, Nureki O.   +11 more
europepmc   +1 more source

Crystallization Scale Preparation of a Stable GPCR Signaling Complex between Constitutively Active Rhodopsin and G-Protein

, 2014
Shoji Maeda, Dawei Sun, Ankita Singhal, Marcello Foggetta, Georg H. Schmid, J. Standfuss, Michael Hennig, Roger Dawson, Dmitry B. Veprintsev, Gebhard F. X. Schertler   +9 more
openalex   +2 more sources

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Developing inhibitors of the guanosine triphosphate hydrolysis accelerating activity of Regulator of G protein Signaling-14. [PDF]

J Biol Chem
Agogo-Mawuli PS, Sadiya I, Abramyan TM, Bosch DE, Emmitte KA, Colón-Pérez LM, Kosloff M, Siderovski DP.   +7 more
europepmc   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Ciliary G-Protein Coupled Receptor Signaling in Polycystic Kidney Disease. [PDF]

Int J Mol Sci
Buqaileh R, Alshriem LA, AbouAlaiwi W.
europepmc   +1 more source

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, EarlyView.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

G protein-mediated signal transduction: a molecular choreography of G protein activation after GTP binding

Signal Transduction and Targeted Therapy
Evi Kostenis, Lars Jürgenliemke, Judith Alenfelder   +2 more
doaj   +1 more source