Results 251 to 260 of about 21,426,917 (362)

Ribosomal protein L1 from Escherichia coli. Its role in the binding of tRNA to the ribosome and in elongation factor g-dependent gtp hydrolysis.

, 1983
Gernot Sander
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Novel atypical G protein-coupled receptor (GPCR)-arrestin complexes: a structural snapshot of the barcode hypothesis. [PDF]

Signal Transduct Target Ther
Filor JC, Matthees ESF, Hoffmann C.
europepmc   +1 more source

4-Deoxy-4-fluoro-D-mannose inhibits the glycosylation of the G protein of vesicular stomatitis virus.

, 1984
Thomas J. Grier, James R. Rasmussen
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Biased agonism of G protein-coupled receptors as a novel strategy for osteoarthritis therapy. [PDF]

Bone Res
Meng X, Qin L, Wang X.
europepmc   +1 more source

Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region

Nature, 2016
AJ Venkatakrishnan, X. Deupí, G. Lebon, G. Lebon, G. Lebon, F. Heydenreich, F. Heydenreich, F. Heydenreich, T. Flock, Tamara Miljuš, Tamara Miljuš, S. Balaji, M. Bouvier, Dmitry B. Veprintsev, Dmitry B. Veprintsev, C. Tate, G. Schertler, G. Schertler, M. Babu   +18 more
semanticscholar   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

G-Protein-Coupled Receptors in Chronic Kidney Disease Induced by Hypertension and Diabetes. [PDF]

Cells
Tang H, Li K, Shi Z, Wu J.
europepmc   +1 more source

Allosteric regulation of G protein-coupled receptor activity by phospholipids.

Nature Chemical Biology, 2016
R. Dawaliby, Cataldo Trubbia, C. Delporte, M. Masureel, P. van Antwerpen, B. Kobilka, C. Govaerts   +6 more
semanticscholar   +1 more source