Results 111 to 120 of about 1,248,743 (307)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Understanding interaction traps

, 2003
We propose the idea of an interaction trap as a consequence of dissonance (or “misunderstanding”) between users and systems. These result in inefficient or failed interactions that, from an objective viewpoint, could have been efficient and ...
Bryan-Kinns, N., Blandford, A., Thimbleby, H.   +2 more
core  

Replication of the association of common rs9939609 variant of FTO with increased BMI in an Australian adult twin population but no evidence for gene by environment (G × E) interaction

, 2009
Objective: To further investigate a common variant (rs9939609) in the fat mass- and obesity-associated gene (FTO), which recent genome-wide association studies have shown to be associated with body mass index (BMI) and obesity.
Martin, N. G., Lind, P. A., Montgomery, G. W., B K Cornes, Cornes, B., Cornes, B. K., Medland, S. E., Nyholt, D. R., Martin, N. G ., D R Nyholt, Nyholt, D.R., G W Montgomery, P A Lind, S E Medland, Montgomery, G. W ., N G Martin   +15 more
core   +1 more source

Genotype x Environment interaction for kernel yield in groundnut (Arachis hypogaea L.) [PDF]

Electronic Journal of Plant Breeding, 2010
Sixteen medium duration groundnut cultures were evaluated for kernel yield, stability and adaptation across fourenvironments. The G X E interaction was highly significant and both linear and non-linear component are equally importantfor yield stability ...
A. Mothilal, P. Vindhiya varman and N. Manivannan
doaj  

G x E interaction and stability analysis of promising rice cultures under different sowing dates during kharif

Electronic Journal of Plant Breeding, 2016
A field experiment was conducted with six advanced Rajendranagar rice cultures along with three popular varieties (BPT 5204, JGL-11470 and MTU-1010) as checks to estimate the stability parameters. The linear part of GxE interactions was significant for plant height, grains per panicle, 1000 grain weight and kernel length.
S. Vanisri, Ch. Surender Raju, Ch. Damodar Raju, P. Raghurami Reddy and, Y. Suryanarayana   +4 more
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Genotype x environment interaction and optimum resource allocation for yield and yield components of cassava

, 2014
Dry yield and yield components from 6 multilocational trials of cassava genotypes conducted for 3 years in Nigeria were used to study the nature and magnitude of genotype x environment (G x E) interaction and to determine the optimum resource allocation ...
Dixon, Alfred G.O., Nukenine, EN
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

G x E interactions and stability analysis for seed cotton yield and its components in cotton(Gossypium hirsutum L.)

Electronic Journal of Plant Breeding
A line x tester analysis using 10 lines and five testers were  carried out to study the stability of 50 hybrids over environments using three different sowing dates for seed cotton yield and its quantitative traits in cotton. The analysis of variance for stability revealed significant differences among the genotypes for all the characters when tested ...
null P. A. Vavdiya, null V. P. Chovatia, null N. M. Bhut, null G. D. Vadodariya   +3 more
openaire   +3 more sources