Results 91 to 100 of about 105,256 (293)

Structure‐Function Integration in 2D Hybrid Perovskite for Fast Neutron and Gamma Ray Discrimination

open access: yesAdvanced Science, EarlyView.
Using an in situ seed‐assisted cooling method, large (28 × 7 × 3 mm3) (GABA)2PbBr4 single crystals are grown, featuring hydrogen‐rich organic layers and a dense PbBr4 framework. This architecture enables efficient γ‐ray absorption, fast‐neutron sensitivity, and clear n/γ pulse‐shape discrimination (FOM up to 1.74), highlighting its potential as a ...
Yingming Wang   +15 more
wiley   +1 more source

Differential roles of EA‐TRAPed cells in the anterior cingulate cortex across various intervention times in inflammatory pain

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The cumulative effect of EA analgesia is partially attributed to the activation of EA‐TRAPed cells in ACC. Multiple EA sessions and single EA sessions activated different neuronal populations in the ACC. The enhanced analgesic effect of multiple EA sessions may be attributed to an increase in the proportion of GABAergic neurons within the ACC. Abstract
Zi Guo   +8 more
wiley   +1 more source

Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-A

open access: yesJournal of Biomedical Science, 2012
Abstact Background Gamma amino butyric acid (GABA), the principal inhibitory neurotransmitter in the cerebral cortex, maintains the inhibitory tones that counter balances neuronal excitation. When this balance is perturbed, seizures may ensue. Methods In
Mathew Jobin   +4 more
doaj   +1 more source

Specific regulation of mechanical nociception by Gβ5 involves GABA-B receptors. [PDF]

open access: yesJCI Insight, 2023
Pandey M   +14 more
europepmc   +1 more source

Back Again to the Future: A New Era for Cerebroprotection

open access: yesAnnals of Neurology, EarlyView.
Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley   +1 more source

GABA-A receptor differences in Schizophrenia

open access: yes, 2020
A loss of GABA signaling is a prevailing hypothesis for the pathogenesis of schizophrenia. Preclinical studies indicate that blockade of the α5 subtype of the GABA receptor (α5-GABA ARs) leads to behavioral phenotypes associated with schizophrenia, and postmortem evidence indicates lower hippocampal α5-GABA ARs protein and mRNA levels in schizophrenia.
Reis Marques, Tiago   +9 more
openaire   +1 more source

Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice

open access: yesAnnals of Neurology, EarlyView.
A Objective The ketogenic diet, a high‐fat, low‐carbohydrate regimen, is often used to treat drug‐resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism of action remains unclear. β‐hydroxybutyrate, a primary circulating ketone body produced by the ketogenic diet, may mediate its ...
Soudabeh Naderi   +10 more
wiley   +1 more source

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