Results 111 to 120 of about 159,869 (159)

GABA and GABA receptors in invertebrates

Seminars in Neuroscience, 1991
Abstract GABA is the major inhibitory transmitter at invertebrate synapses in both the central and peripheral nervous systems. The receptors for GABA are well characterised electrophysiologically in a wide variety of invertebrate organisms but their biochemical and pharmacological profiles are less well defined. In general invertebrate GABA receptors
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Pharmacology of GABA

Clinical Neuropharmacology, 1982
GABA-ergic systems are involved in all the main functions of the brain. In most brain regions impairment of this system produces epileptic activity. GABA-mediated inhibitory function can be enhanced by drugs of at least seven different types. They act on the metabolism or synaptic release of GABA, or its reuptake into neurones of glia, or on various ...
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Locating GABA in GABA receptor binding sites

Biochemical Society Transactions, 2009
The Cys-loop family of ligand-gated ion channels contains both vertebrate and invertebrate members that are activated by GABA (γ-aminobutyric acid). Many of the residues that are critical for ligand binding have been identified in vertebrate GABAA and GABAC receptors, and specific interactions between GABA and some of these residues have been ...
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GABA agonists

Molecular and Cellular Biochemistry, 1981
This review describes the development of GABA receptor agonists with no detectable affinity for other recognition sites in GABA-mediated synapses. The key compounds are THIP, isoguvacine, and piperidine-4-sulphonic acid (P4S), developed via extensive structural modifications of the potent but not strictly specific GABA agonist muscimol.
P, Krogsgaard-Larsen, E, Falch
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Effects of γ-acetylenic GABA and γ-vinyl GABA on synaptosomal release and uptake of GABA

Biochemical Pharmacology, 1981
Abstract The effects of the irreversible inhibitors of GABA-transaminase (E.C.2.6.1.19), γ-acetylenic GABA (4-amino-hex-5-ynoic acid, RMI 71645) and γ-vinyl GABA (4-amino-hex-5-enoic acid, RMI 71754) on the release and uptake of endogenous and exogenous GABA by rat cerebral cortical synaptosomes were studied.
A S, Abdul-Ghani, P J, Norris, C C, Smith, H F, Bradford   +3 more
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GABA-noradrenergic interaction: Evidence for differential sites of action for GABA-A and GABA-B receptors

Journal of Neural Transmission, 1985
Treatment of mice with DSP4 (a neurotoxin that abolishes the presynaptic noradrenergic neuron; Dooley et al., 1983) resulted in: (A) a decrease in the Bmax for the low affinity GABA-B receptor site in the cerebral cortex and hippocampus, whereas the Bmax for the high affinity GABA-B receptor site was unaffected; (B) a greater potentiation of ...
P D, Suzdak, G, Gianutsos
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CHLORPROMAZINE AND GABA

Annals of the New York Academy of Sciences, 1969
H C, Agrawal, J M, Davis, E E, Haynes, W A, Himwich   +3 more
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GABA

British Journal of Pharmacology, 2006
S P H Alexander, A Mathie, J A Peters
  +4 more sources

The postnatal GABA shift: A developmental perspective

Neuroscience and Biobehavioral Reviews, 2021
Corette J Wierenga, Carlijn Peerboom
exaly  

GABA regulates IL-1β production in macrophages

Cell Reports, 2022
Yaoyao Xia, Yulong Yin, Wenkai Ren
exaly