Results 121 to 130 of about 219,640 (255)
The controlled pH-based crystallization approach with acetic acid to the pharmaceutical interesting metastable polymorph II of the API γ-aminobutyric acid (GABA), which is hitherto accessible by sublimation under reduced pressure and high temperature, is
Laura Lamkowski (9034439) +2 more
core +1 more source
Opsoclonus in Pediatric Patients: Differential Diagnosis and a Practical Approach to Evaluation
Annals of the Child Neurology Society, EarlyView.ABSTRACT Opsoclonus is an ocular dyskinesia characterized by involuntary, arrhythmic, multidirectional saccades. In pediatrics, opsoclonus is most commonly attributed to the rare neuroinflammatory disorder opsoclonus‐myoclonus‐ataxia syndrome (OMAS), typically considered a paraneoplastic syndrome associated with neural crest tumors. However, opsoclonus
Aubrey C. Reed +5 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.A mechanistic CNS PBPK model framework was applied to eight antipsychotic D2 receptor ligands, comparing brain extracellular fluid (brainECF) and brain cell membrane (brainM) as biophase for predicting human receptor occupancy compared against PET neuroimaging data. BrainM concentrations showed improved agreement with PET‐derived receptor occupancy for
Divakar Budda +2 more
wiley +1 more source
The antioxidant activity and protective effect against LPS -induced microglia toxicity of GABA tea
, 2011 [[abstract]]GABA as a kind of tea contains a high amount of γ-amino butyric acid (γ-aminobutyric acid, GABA) natural tea products. Dr. Tian Jin Chi in the Japanese (1987) study the process of how to preserve fresh ingredients Fresh Tea Leaves, and found ...
CHANG JUNE-SHAN
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Developmental Dynamics, EarlyView.Abstract The sea anemone, Nematostella vectensis, has been used as a model organism in developmental biology studies for many years. This estuarine species has the notable capacity to regenerate its full body plan from small pieces throughout life. Nematostella have been described as having a great degree of cellular plasticity.
Patrick A. Lewis +3 more
wiley +1 more source
GABAergic inhibition controls neural gain in inferior colliculus neurons sensitive to interaural time differences [PDF]
, 2005 We investigated the role of GABAergic inhibition on the responses of inferior colliculus (IC) neurons sensitive to interaural time differences (ITDs) in anesthetized guinea pigs.
Ingham, NJ, Mcalpine, D
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The EuroBiotech JournalBackground/aim: Acetaminophen is frequently used as an analgesic during pregnancy. The purpose of the present study was to evaluate the effects of acetaminophen administered to pregnant mice on the fetal brain, attention, memory, and learning functions ...
Göl Mehmet Fatih +8 more
doaj +1 more source
Exploring the efficacy and safety of perampanel in epilepsia partialis continua: A case series
Epileptic Disorders, EarlyView.Abstract Background Epilepsia partialis continua (EPC) is a form of focal motor status epilepticus (SE), which is commonly drug‐resistant requiring treatment with multiple antiseizure medications (ASM). There are no established guidelines for pharmacological management.
Setareh Lahsaee +3 more
wiley +1 more source
Epileptic Disorders, EarlyView.Abstract Pathogenic SV2A gene variants have been reported as causes of epilepsy and are often associated with drug resistance and susceptibility to fever‐related seizures. No highly effective treatments have been established for this condition. We report a female patient with a family history of epilepsy who developed generalized seizures associated ...
Takayuki Mori +4 more
wiley +1 more source
The pharmacokinetics and neuropharmacological action of the new antiepileptic drugs vigabatrin and levetiracetam. [PDF]
, 2007 Epilepsy affects approximately 1% of the world population and is the most serious neurological conditions. In the UK, 30-35,000 new cases of epilepsy are diagnosed each year, resulting in a prevalence of 300,000 nationwide.
Tong, X.
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