Structural basis for activation and potentiation in a human α5β3 GABA<sub>A</sub> receptor. [PDF]
Nat CommunCowgill J +4 more
europepmc +1 more source
The multiple hit model of infantile and epileptic spasms: The 2025 update
Epilepsia Open, EarlyView.Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou +6 more
wiley +1 more source
Ketogenic diet for infantile epileptic spasms
Epilepsia Open, EarlyView.Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury +3 more
wiley +1 more source
GABA-mediated regulation of lipid metabolism: a conserved relation with diverse physiological significances. [PDF]
Front PhysiolPradhan S +4 more
europepmc +1 more source
Epilepsy surgery: From bench to the clinics
Epilepsia Open, EarlyView.Abstract Objective Recent advances in epilepsy surgery in patients with intractable epilepsy make it possible to study the mechanism of epilepsy in human brains. However, the true extent and propagation of each epileptogenic area from the epileptogenic focus in each patient is still difficult to perform “epilepsy cure” by surgery.
Tatsuya Tanaka
wiley +1 more source
Network functional connectivity and anterior cingulate cortex gamma-aminobutyric acid in antipsychotic medication-naïve first-episode psychosis patients. [PDF]
Psychol MedSamson GD +5 more
europepmc +1 more source
Neonatal seizures and GABAergic drugs: Scylla and Charybdis?
Epilepsia Open, EarlyView.Abstract Neonates have a high incidence of seizures that are frequently difficult to control with conventional first‐line anti‐seizure medications, which are gamma‐aminobutyric acid (GABA) agonists. The reasons for this clinical problem are multifold but are likely related to the unique physiology of the immature nervous system. Specifically, the early
Kerry W. Thompson +2 more
wiley +1 more source
Age-dependent alterations in anterior cingulate excitation-inhibition balance in major depressive disorder revealed by 7-Tesla magnetic resonance spectroscopy. [PDF]
Neuroimage ClinYoshihara Y +9 more
europepmc +1 more source
Epilepsia Open, EarlyView.Abstract Objective Cenobamate (CNB) is an effective antiseizure medication, though its mechanisms of efficacy remain incompletely understood. We assessed changes in cortical responses to transcranial magnetic stimulation (TMS) following CNB treatment.
Silvano R. Gefferie +7 more
wiley +1 more source
BioResourcesThe effect of Callicarpa kwangtungensis Chun (CKC) was evaluated in Pilocarpine (P350, 350 mg/kg)-induced epilepsy in mice. The behavioral patterns of experimental mice were investigated by the number of convulsed animals, survivors, after P350-induced ...
Shiqing Li +5 more
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