Results 241 to 250 of about 470,203 (387)

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, EarlyView.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source

Transcutaneous vagus nerve stimulation reduces total striatal GABA+ content, increases DLPFC Glu content, and facilitates early-phase motor learning. [PDF]

Front Hum Neurosci
Matsumura K, Matsuta H, Kawasoe R, Fumuro T, Matsushita K, Hata N, Asayama Y, Shimomura T, Fujiki M, Sugata H.   +9 more
europepmc   +1 more source

Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management

Journal of Applied Toxicology, EarlyView.
ABSTRACT Ivermectin is a widely used macrocyclic lactone with established efficacy against a broad range of parasitic infections in humans and animals and a long‐standing reputation for clinical safety. However, increasing evidence indicates that ivermectin can produce clinically relevant toxicity under specific conditions, particularly involving the ...
Serkan Yilmaz, Bayram Göktaş, İlker Ateş, Mustafa Çelik   +3 more
wiley   +1 more source

Chloride homeostasis dysfunction drives hyperactivation of corticotropin-releasing factor-expressing neurons in the amygdala in stress-induced hypertension. [PDF]

J Clin Invest
Ma H, Zhang Y, Guo X, Zhao Q, Yang P, Liu Y, Guan Y, Wei Y, Ma H.   +8 more
europepmc   +1 more source

GABA Depolarization Is Required for Experience-Dependent Synapse Unsilencing in Adult-Born Neurons [PDF]

, 2013
Jessica H. Chancey, Elena W Adlaf, Matthew C. Sapp, Phyllis C. Pugh, Jacques I. Wadiche, Linda Overstreet‐Wadiche   +5 more
openalex   +1 more source

GABA regulates synaptic integration of newly generated neurons in the adult brain

Nature, 2006
S. Ge, E. Goh, K. Sailor, Yasuji Kitabatake, G. Ming, Hongjun Song   +5 more
semanticscholar   +1 more source

Things We Do for No Reason™: Prescribing gabapentinoids for pain

Journal of Hospital Medicine, EarlyView.
Abstract Gabapentin and pregabalin are among the most frequently prescribed medications in the United States, with gabapentin in the top 10 and pregabalin in the top 100. Despite FDA approval for only select neuropathic conditions, most use is for off‐label pain indications.
Niti G. Patel, David Goese, Steven M. Belknap, Charles L. Madeira, Jeffrey H. Barsuk   +4 more
wiley   +1 more source

Effects of <i>in vitro</i> fermentation of <i>Astragalus</i> polysaccharide on gut microbiota and neurotransmitter metabolites in patients with major depressive disorder. [PDF]

Front Psychiatry
Lin C, Mi YW, Zheng HW, Hou YB, Hu JQ, Mao JX, Dai N, Fu CL, Li XQ, Ji YX.   +9 more
europepmc   +1 more source

Structure–Activity Studies of Cysteine‐Rich α‐Conotoxins that Inhibit High‐Voltage‐Activated Calcium Channels via GABA_B Receptor Activation Reveal a Minimal Functional Motif [PDF]

, 2016
Bodil B. Carstens, Géza Berecki, James T. Daniel, Han Siean Lee, Kathryn Jackson, Han‐Shen Tae, Mahsa Sadeghi, Joel Castro, Tracy O'Donnell, Annemie Deiteren, Stuart M. Brierley, David J. Craik, David J. Adams, Richard J. Clark   +13 more
openalex   +1 more source

Genetic and Molecular Regulation of Extrasynaptic GABA-A Receptors in the Brain: Therapeutic Insights for Epilepsy

Journal of Pharmacology and Experimental Therapeutics, 2018
Shu-Hui Chuang, D. Reddy
semanticscholar   +1 more source