Results 281 to 290 of about 163,092 (297)
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GABA binding in mammalian brain: Inhibition by endogenous GABA
Life Sciences, 1980Abstract Sodium-independent binding of gamma aminobutyric acid (GABA) to receptor-like sites in mammalian brain homogenates was much greater in membrane fractions which had been thoroughly washed with buffer, or detergent, and frozen and thawed several times, than in fresh unwashed membranes.
D. V. Greenlee +4 more
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Neurosteroid modulation of allopregnanolone and GABA effect on the GABA-A receptor
Neuroscience, 2006The neurosteroid allopregnanolone (ALLO) or 3alpha-OH-5alpha-pregnane-20-one interacts with the GABA type A receptor chloride ion channel complex and enhances the effect of GABA. Animal and human studies suggest that ALLO plays an important role in several disorders including premenstrual syndrome, anxiety, and memory impairment.
Jessica Strömberg +4 more
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The depolarizing GABA response
Canadian Journal of Physiology and Pharmacology, 1997In some situations the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) elicits a hyperpolarizing response (H response) followed by a depolarizing response (D response) on cortical neurons. It has recently been established that the D response on hippocampal pyramidal cells is largely carried by bicarbonate ions (HCO3-).
Robert K. S. Wong, Katherine L. Perkins
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Future Medicinal Chemistry, 2011
The neurotransmitter GABA is the main inhibitory neurotransmitter of the CNS. It is estimated that 20-50% of all neuronal synapses are GABAergic. Distinct types of GABA receptor have been identified (GABA(A), GABA(B) and GABA(AOr) [GABA(C)]). The GABA(A) and GABA(AOr) variant found in the retina receptors (informally termed GABA(C)) are physiologically
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The neurotransmitter GABA is the main inhibitory neurotransmitter of the CNS. It is estimated that 20-50% of all neuronal synapses are GABAergic. Distinct types of GABA receptor have been identified (GABA(A), GABA(B) and GABA(AOr) [GABA(C)]). The GABA(A) and GABA(AOr) variant found in the retina receptors (informally termed GABA(C)) are physiologically
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The Neurobiology of Gaba Receptors
2006Gamma-aminobutyric acid (GABA) was first identified in 1950 (Roberts 1950; Awapara 1950) in brain extracts of various animal species and was subsequently found to be the principal inhibitory neurotransmitter in the central nervous system (CNS). GABA is synthesized as a result of decarboxylation of glutamic acid and is released by neurons into the ...
SANNA, ENRICO, FOLLESA, PAOLO, BIGGIO G.
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Effects of GABA-T inhibitors and GABA uptake blockers on gaba metabolism in vivo
Brain Research Bulletin, 1979P.V. Taberner, C.B. Charington
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Chapter 10 GABA and Neuroprotection
1996Publisher Summary Gamma aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in mammalian brain. GABA neurotransmission results in increased chloride flux across the postsynaptic membrane and hyperpolarization. In many ways, these actions counterbalance the physiological and toxic effects of glutamate.
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