Results 281 to 290 of about 470,203 (387)

Spectral Representation of Neurochemicals With Phase, Frequency Offset, and Lineshape Invariance: Application to JPRESS for In Vivo Concentration and T2 Mapping by Deep Learning

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Using artificial intelligence neural networks to generate a representation that maps the input directly to neurochemical concentrations and metabolite‐level average transverse relaxation times (T2). Methods The proposed model used time‐domain JPRESS data as input and was trained to be invariant to phase shifts, frequency offsets, and ...
Yan Zhang, Jun Shen
wiley   +1 more source

Medicines for Anxiety: A Hundred Years of Tranquillity and More to Come? [PDF]

Hum Psychopharmacol
Nutt D.
europepmc   +1 more source

GABA A receptors: subtypes provide diversity of function and pharmacology.

Neuropharmacology, 2009
R. Olsen, W. Sieghart
semanticscholar   +1 more source

Effect of Water Suppression and Metabolite Cycling on Quantification of 1H MRS Spectra in the Human Brain at 3 Tesla

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose This study investigates the effect of VAPOR water suppression and metabolite cycling on metabolite quantification and macromolecules in proton magnetic resonance spectroscopy. Methods Single‐voxel semi‐LASER spectra (TR/TE = 3000/28 ms) and metabolite‐nulled spectra (macromolecules) were acquired in five healthy subjects in the ...
Dinesh K. Deelchand, Pierre‐Gilles Henry   +1 more
wiley   +1 more source

Pacific Blue Derivatives of Paclitaxel as Fluorescent Probes of OATP1B-Type Transporters. [PDF]

Clin Transl Sci
Nepal MR, Xu Y, Jin Y, Hu P, Hu X, Rane DS, Andres AE, Ahmed EA, Steiger B, Sparreboom A, Peterson BR, Hu S.   +11 more
europepmc   +1 more source

Chronic gabapentinoid exposure may indirectly dysregulate GABA-A receptor signaling and inhibitory–excitatory balance; flumazenil could theoretically “reset” maladaptive GABA-A receptor states, reducing craving or withdrawal-related anxiety.

Mahdy A.A Osman
openalex   +1 more source

Modifying Antibiotic Activity of Synthetic Thiadiazine Analogs Against MDR Bacteria and ADMET Analysis

ChemistryOpen, EarlyView.
The study demonstrated that thidiazine compounds potentiated the action of antibiotics. The compounds associated with norfloxacin against S. aureus showed greater significance in relation to the other medications. The indiscriminate use of antibiotics has led to the selection of resistant bacterial strains, significantly reducing the effectiveness of ...
João Arthur de Oliveira Borges, Priscilla Ramos Freitas, Isaac Moura Araújo, Ray Silva de Almeida, Igor José dos Santos Nascimento, João Xavier de Araújo‐Júnior, Edeildo Ferreira da Silva‐Júnior, Thiago Mendonça de Aquino, Francisco Jaime Bezerra Mendonça Junior, Emmanuel Silva Marinho, Hélcio Silva dos Santos, Radosław Kowalski, Grażyna Kowalska, Henrique Douglas Melo Coutinho, Saulo Relison Tintino, Ana Carolina Justino de Araújo   +15 more
wiley   +1 more source

Application of γ-aminobutyric acid alleviates salinity-mediated growth decline and oxidative damage by increasing proline and antioxidant functioning in olive (Olea europaea L.). [PDF]

Front Plant Sci
Alnusaire TS.
europepmc   +1 more source