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Critical reviews in food science and nutrition, 2023
Gamma-aminobutyric acid (GABA) is a naturally occurring potential bioactive compound present in plants, microorganisms, animals, and humans. Especially, as a main inhibitory neurotransmitter in the central nervous system, GABA possesses a broad spectrum ...
D. Hou +6 more
semanticscholar +1 more source
Gamma-aminobutyric acid (GABA) is a naturally occurring potential bioactive compound present in plants, microorganisms, animals, and humans. Especially, as a main inhibitory neurotransmitter in the central nervous system, GABA possesses a broad spectrum ...
D. Hou +6 more
semanticscholar +1 more source
Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis
Cell, 2017 Andhira Vieira +2 more
exaly +2 more sources
GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease
Nature Medicine, 2014 Seonmi Jo, Oleg Yarishkin, Mijeong Park
exaly +2 more sources
The role of GABA in the pathophysiology and treatment of anxiety disorders.
Psychopharmacology bulletinMechanisms underlying the pathological characteristics of the various anxiety disorders have yet to be fully elucidated. One of the most widely accepted mediators known to play a central role in the pathophysiology of anxiety disorders is the g ...
C. Nemeroff
semanticscholar +1 more source
Locating GABA in GABA receptor binding sites
Biochemical Society Transactions, 2009The Cys-loop family of ligand-gated ion channels contains both vertebrate and invertebrate members that are activated by GABA (γ-aminobutyric acid). Many of the residues that are critical for ligand binding have been identified in vertebrate GABAA and GABAC receptors, and specific interactions between GABA and some of these residues have been ...
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Glia, 1994
AbstractGABA receptors are distributed widely throughout the central nervous system on a variety of cell types. It has become increasingly clear that astrocytes, both in cell culture and tissue slices, express abundant GABAA receptors. In astrocytes, GABA activates Cl−‐specific channels that are modulated by barbiturates and benzodiazepines; however ...
D D, Fraser +2 more
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AbstractGABA receptors are distributed widely throughout the central nervous system on a variety of cell types. It has become increasingly clear that astrocytes, both in cell culture and tissue slices, express abundant GABAA receptors. In astrocytes, GABA activates Cl−‐specific channels that are modulated by barbiturates and benzodiazepines; however ...
D D, Fraser +2 more
openaire +2 more sources
Current Medical Research and Opinion, 2002
Neuroprotective agents inhibit reactions in the brain ischaemic injury cascade which lead to neuronal death. Gamma-aminobutyric acid (GABA) is a naturally occurring inhibitory neurotransmitter that increases chloride influx into the neuron and counteracts the toxic effects of glutamate.
Anand, Vaishnav, Helmi L, Lutsep
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Neuroprotective agents inhibit reactions in the brain ischaemic injury cascade which lead to neuronal death. Gamma-aminobutyric acid (GABA) is a naturally occurring inhibitory neurotransmitter that increases chloride influx into the neuron and counteracts the toxic effects of glutamate.
Anand, Vaishnav, Helmi L, Lutsep
openaire +2 more sources
GABA Transporters and GABA-Transaminase as Drug Targets
Current Drug Target -CNS & Neurological Disorders, 2003The fine-tuning and homeostatic balance of the GABAergic inhibitory tone in the central nervous system (CNS) is a prerequisite for controlling the excitatory neurotransmission. This principal mechanism for controlling excitation is inhibition which has been the topic of intensive research covering all known functional entities of the GABAergic synapse.
Alan, Sarup +2 more
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1979
In summary, several branched-chain fatty acids appeared to be competitive inhibitors of GABA-T and non-competitive inhibitors of SSADH. These compounds produce an increase in brain GABA level, and for two of these it was shown that the increase differs among various brain areas. An increase of GABA cannot be obtained by inhibition of SSADH.
L, Ciesielski +8 more
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In summary, several branched-chain fatty acids appeared to be competitive inhibitors of GABA-T and non-competitive inhibitors of SSADH. These compounds produce an increase in brain GABA level, and for two of these it was shown that the increase differs among various brain areas. An increase of GABA cannot be obtained by inhibition of SSADH.
L, Ciesielski +8 more
openaire +2 more sources