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Reducing GABA Receptors

Life Sciences, 2003
A number of important drugs act on GABA(A) receptors, pentameric GABA-gated chloride channels assembled from among 19 known subunits. In trying to discover the roles in the brain of the subunits and their combinations, with the goal of developing more selective drugs, one tool has been to reduce expression of the subunits and examine the functional ...
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GABA and GABA receptors in invertebrates

Seminars in Neuroscience, 1991
Abstract GABA is the major inhibitory transmitter at invertebrate synapses in both the central and peripheral nervous systems. The receptors for GABA are well characterised electrophysiologically in a wide variety of invertebrate organisms but their biochemical and pharmacological profiles are less well defined. In general invertebrate GABA receptors
openaire   +1 more source

The K+/Cl− co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation

Nature, 1999
C. Rivera   +8 more
semanticscholar   +1 more source

GABA

2022
Sireesha Murala   +3 more
openaire   +1 more source

Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor.

Science, 1986
Majewska   +4 more
semanticscholar   +1 more source

GABA-benzodiazepine receptors

American Journal of Psychiatry, 1992
openaire   +2 more sources

GABA-drug interactions

1987
γ-Aminobutyric acid is the major inhibitory neurotransmitter in the central nervous system and is widely utilized in virtually all anatomic regions of the brain and spinal cord [1,2]. In recent years, pharmacological evidence at all levels (organismal, tissue, cellular, and molecular) have implicated GABA in a variety of human clinical problems and ...
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Structural basis of GABA reuptake inhibition

Nature, 2022
Zenia Motiwala   +2 more
exaly  

GABA

2010
Husseini K. Manji   +58 more
openaire   +3 more sources

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