Results 81 to 90 of about 343,837 (291)

A tight coupling between β\u3csub\u3e2\u3c/sub\u3eY97 and β\u3csub\u3e2\u3c/sub\u3eF200 of the GABA\u3csub\u3eA\u3c/sub\u3e receptor mediates GABA binding [PDF]

, 2011
The GABAA receptor is an oligopentameric chloride channel that is activated via conformation changes induced upon the binding of the endogenous ligand, GABA, to the extracellular inter-subunit interfaces. Although dozens of amino acid residues at the α/β
Laha, Kurt T., Tran, Phu N., Wagner, David A.   +2 more
core   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy

Advanced Science, EarlyView.
This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao, Qingqing Zhou, Mengli Li, Wen Zou, Zhenzhong Zhang, Jinjin Shi, Junjie Liu   +6 more
wiley   +1 more source

Current concepts of pathogenesis of depressive disorder: A literature review

Research Results in Pharmacology
Introduction: Despite the high prevalence of depressive disorders, the pathogenesis of depression has not been fully established. Recently, a significant number of works have been published demonstrating mechanisms of development of this pathology that ...
Alexander A. Spasov, Dmitriy V. Maltsev, Maria O. Maltseva   +2 more
doaj   +1 more source

Decreased serum level of gamma-amino butyric acid in egyptian infertile females with polycystic ovary syndrome is correlated with dyslipidemia, total testosterone and 25(OH) vitamin D levels [PDF]

Journal of Medical Biochemistry, 2019
Background: Polycystic ovary syndrome (PCOS) is one of the most common female endocrine disorders around the world. Increasing evidence suggests that neurotransmitter Gamma-aminobutyric acid (GABA) is involved in the pathogenesis of PCOS through its ...
Radwan Rasha A., Abuelezz Nermeen Z., Abdelraouf Sahar M., Bakee Engy M., Abd-El-rahman Abdullah A.   +4 more
doaj  

An Automated Organotypic SCN Culture System Revealing Novel Insights into VIP Regulation of Circadian Rhythm

Advanced Science, EarlyView.
An Automated ex vivo culture system BaSIC, tailored for SCN slices and cell culture, which automates medium exchange and ensures a stable internal environment is developed. BaSIC enables real‐time observation of tissue/cell responses to diverse but programmed stimuli.
Kui Han, Meimei Liao, Jingpeng Zhang, Ruoyu Zhong, Long Mei, Dapeng Ju, Eric Erquan Zhang, Yanyi Huang   +7 more
wiley   +1 more source

Isolation and Production of γ-Aminobutyric Acid (GABA) from Lactic Acid Bacteria from Seredele, a Balinese Fermented Soybean

Agritech
γ-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter with beneficial effects on human health. Therefore, this study aimed to isolate lactic acid bacteria (LAB) from seredele, a Balinese fermented soybean, with GABA-producing potential.
Ida Bagus Agung Yogeswara, Ni Wayan Nursini, Purwaningtyas Kusumaningsih, I Gusti Ayu Kusumawati   +3 more
doaj   +1 more source

Aging and GABA

Aging, 2018
sponsorship: This work was supported by the Research Fund KU Leuven (C16/15/070) and the Research Foundation Flanders (FWO) grant (G089818N) and Excellence of Science grant (EOS 30446199, MEMODYN) awarded to SPS. CM is funded by an aspirant fellowship of the Research Foundation Flanders (FWO).
Cuypers, Koen, Maes, Celine, Swinnen, Stephan   +2 more
openaire   +3 more sources

Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model

Advanced Science, EarlyView.
Transplantation of medial ganglionic eminence (MGE) interneuron progenitors into APP/PS1 cortices restored the slow oscillation characteristic of Alzheimer's disease. Donor cells survived, migrated, and matured into functional GABAergic interneurons, forming synaptic connections.
Shinya Yokomizo, Megi Maci, April M. Stafford, Morgan R. Miller, Stephen J. Perle, Shuzo Inagaki, Shusaku Takahashi, Heather Brown‐Harding, Linda Liang, Alex Lovely, Moustafa Algamal, Rebecca L. Gillani, Theodore J. Zwang, Douglas Richardson, Janice R. Naegele, Daniel Vogt, Ksenia V. Kastanenka   +16 more
wiley   +1 more source

Bibliometric Analysis on GABA-A Receptors Research Based on CiteSpace and VOSviewer

Journal of Pain Research, 2023
Xufeng Yu,1,* Zhan Gao,1,* Mingzhou Gao,2 Mingqi Qiao1 1College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, People’s Republic of China; 2Innovation Research Institute of ...
Yu X, Gao Z, Gao M, Qiao M
doaj