Results 81 to 90 of about 258,602 (310)

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Pharmacological Discrimination of Effects of MK801 on Thalamocortical, Mesothalamic, and Mesocortical Transmissions

Biomolecules, 2019
N-methyl-d-aspartate/glutamate receptor (NMDAR) is one of the major voltage-sensitive ligand-gated cation channel. Several noncompetitive NMDAR antagonists contribute to pathophysiology of schizophrenia and mood disorders; however, the effects of ...
Motohiro Okada, Kouji Fukuyama, Tomosuke Nakano, Yuto Ueda   +3 more
doaj   +1 more source

Latency and amplitude of the stop-signal P3 event-related potential are related to inhibitory GABA_aactivity in primary motor cortex [PDF]

, 2020
Megan Hynd, Cheol Soh, Benjamin O. Rangel, Jan R. Wessel   +3 more
openalex   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, EarlyView.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

Allele‐Specific Regulation of PAXIP1‐AS1 by SMC3/CEBPB at rs112651172 in Psychiatric Disorders Drives Synaptic and Behavioral Dysfunctions in Mice

Advanced Science, EarlyView.
This study identifies a functional noncoding variant, rs112651172 (C/G), that drives allele‐specific expression of PAXIP1‐AS1 in monozygotic twin pairs discordant for schizophrenia and bipolar disorder. The risk G allele enhances CEBPB binding, leading to lncRNA upregulation, CNTNAP3 derepression, and synaptic and behavioral deficits in mice.
Chaoying Ni, He Chen, Qiaqi Chen, Yangyang Liao, Yunqian Wang, Linyan Ye, Xiaohui Wu, Hongyu Ni, Tingyun Jiang, Shufen Li, Qiong Yang, Hong Xue, Zhongju Wang, Feng Yi, Cunyou Zhao   +14 more
wiley   +1 more source

Efecto antagonista del flumazenil sobre el isoflurano en la emersión de la anestesia general [PDF]

Revista Chilena de Anestesia, 2020
Jonathan De Freitas H., Javier Eduardo Moreno Sánchez, María Victoria Amaro S.   +2 more
doaj   +1 more source

Influence of Harvesting Time on Phytochemical Content of Colored Brown and Parboiled Rice

AGRIVITA Journal of Agricultural Science
Colored rice receives more attention from consumers because of its high phytochemicals and antioxidant activity beneficial to health. The aims of this investigation were to quantify the important phytochemicals and antioxidant activity in three varieties
Nattareeporn Rodnuch, Kiattisak Burum, Chorkaew Aninbon   +2 more
doaj   +1 more source

Multiscale Cell–Cell Interactive Spatial Transcriptomics Analysis

Advanced Science, EarlyView.
In this study, we present the MultiScale Cell‐Cell Interactive Spatial Transcriptomics Analysis method, which unites the strengths of spatially resolved deep learning techniques with a topological representation of multi‐scale cell‐cell similarity relations.
Sean Cottrell, Guo‐Wei Wei
wiley   +1 more source

Analysis of the protective effects of γ-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice

Pharmaceutical Biology, 2019
Context: Compounds to treat hypothyroidism in the absence of cardiac side effects are urgently required. In this regard, γ-aminobutyric acid (GABA) has gained interest due to its anti-anxiolytic, antihypertensive and antioxidant properties, and reported ...
Haoyue Yang, Ronge Xing, Song Liu, Huahua Yu, Pengcheng Li   +4 more
doaj   +1 more source

Effect of Phytohormones of Kinetin and Epibrassinolide on Content and Intracellular Localization of Glucosides and Free Amino Acids in Pea Plants Cells (Pisum sativum L.)

International Journal of Secondary Metabolite, 2018
During injection of kinetin and epibrassinolide in pea seedlings (Pisum sativum L.) an increase of content of specific for this compound isosuccinimide-β-glucoside (IS-glucoside) for 15-30%, ethyl-β-glucoside for 40-80%, GABA free amino acids, glutamate ...
Antonina N. Ershova, Natalia Vinokurova   +1 more
doaj   +1 more source