NSAIDS AS MODULATORS OF CATION CHANNELS: FENAMATES REPURPOSING IN CHANNELOPATHIES
ChemMedChem, Accepted Article.Cationic ion channels are transmembrane proteins that regulate the flux of cations (potassium, sodium, and calcium) across cell membrane, playing a pivotal role in many cellular functions. Disruptions of their activity can lead to the so‐called genetic or acquired channelopathies, a heterogeneous group of diseases that affect multiple human systems ...
Paola Laghetti +4 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Selective N‐methyl‐D‐aspartate receptor subunit 2b negative allosteric modulators (NR2B NAMs) are being explored as potential new treatment options for major depressive disorder (MDD). This Phase Ib, randomized, double‐blind, placebo‐controlled, parallel‐group trial was conducted in adults (N = 59) with moderate‐to‐severe MDD and insufficient response ...
Roger S. McIntyre +9 more
wiley +1 more source
Gama-aminobutyric acid (GABA) alleviates hepatic inflammation via GABA receptors/TLR4/NF-κB pathways in growing-finishing pigs generated by super-multiparous sows. [PDF]
Anim Nutr, 2022 Zhang S +6 more
europepmc +1 more source
The Depositional Record, EarlyView.A new classification for inland freshwater palaeowetlands to be used in the field or core laboratory by sedimentologists, providing examples from the Guadix Basin (southern Spain). Abstract Present wetlands have proven to be delicate, biodiverse ecosystems, that are natural sinks for CO2 and act as good indicators for climate changes.
S. Pla‐Pueyo +1 more
wiley +1 more source
High mRNA expression of GABA receptors in human sperm with oligoasthenoteratozoospermia and teratozoospermia and its association with sperm parameters and intracytoplasmic sperm injection outcomes. [PDF]
Clin Exp Reprod Med, 2021 Kaewman P +3 more
europepmc +1 more source
Seminars in epileptology: How to diagnose status epilepticus in adults and children
Epileptic Disorders, EarlyView.Abstract Status epilepticus (SE) can be regarded as the most severe expression of seizure activity characterized by a low probability of spontaneous cessation and mechanisms leading to metabolic and inflammatory derangements with increased risk of brain damage, alterations of neural networks, and potentially life‐threatening systemic complications ...
M. Leitinger +12 more
wiley +1 more source
The alpha1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala. [PDF]
, 2009 Synaptic plasticity in the amygdala is essential for emotional learning. Fear conditioning, for example, depends on changes in excitatory transmission that occur following NMDA receptor activation and AMPA receptor modification in this region.
Cook, James M +10 more
core
Epileptic Disorders, EarlyView.Abstract Objective Status non‐epilepticus is characterized by recurrent or prolonged psychogenic non‐epileptic seizures (PNES), which are often mistaken for status epilepticus (SE). This study focuses on the misdiagnosis of convulsive SE in patients whose seizures were of psychogenic origin.
Ronen Spierer, Moshe Herskovitz
wiley +1 more source
The distribution of GABA sensitivity on crayfish muscle receptor organs.
, 1976 William Craelius
openalex +1 more source
Pre- and postnatal development of GABA receptors in Macaca monkey visual cortex [PDF]
, 1991 C. Shaw +5 more
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