Results 271 to 280 of about 171,989 (360)

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

A GLP‐1R/Y1 receptor/Y2 receptor triple agonist decreases fentanyl‐evoked dopamine release in the nucleus accumbens and attenuates fentanyl taking and seeking in rats

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Emerging literature indicates that simultaneously targeting glucagon‐like peptide‐1 receptors (GLP‐1Rs) and neuropeptide Y receptors (Y1/Y2) may represent a new pharmacotherapeutic approach to treating opioid use disorder (OUD).
Antonia Caffrey, Enzo Lavecchia, Kylie S. Chichura, Matthew R. Hayes, Robert P. Doyle, Heath D. Schmidt   +5 more
wiley   +1 more source

Exploring the pathophysiology underlying clozapine‐induced enhancement of glutamatergic transmission through L‐glutamate and D‐serine release associated with pannexin1 hemichannels

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Clozapine, an approved antipsychotic for treatment‐resistant schizophrenia (TRS), enhances glutamatergic transmission by increasing exocytosis and non‐exocytosis glutamate release; however, its full action remained to be clarified.
Motohiro Okada, Ruri Okubo, Eishi Motomura   +2 more
wiley   +1 more source

From the gut to the brain, mechanisms and clinical applications of γ-aminobutyric acid (GABA) on the treatment of anxiety and insomnia. [PDF]

Front Neurosci
Jiang C, Chen Y, Sun T.
europepmc   +1 more source

Structure–activity relationship of the allosteric effects of ivermectin at human P2X4 and GABAA receptors

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Positive allosteric modulation of the P2X4 receptor is a potential route to providing cardiovascular benefit through enhancing flow‐dependent arterial vasodilation and providing cardioprotection. However, ligands that selectively enhance P2X4 activity are absent.
Jessica L. Meades, Marcella Bassetto, Marius C. Staiculescu, Gayathri Swaminath, Samuel J. Fountain   +4 more
wiley   +1 more source

Chronic α5-GABA-A Receptor Potentiation Promotes Mouse Adult Hippocampal Neurogenesis. [PDF]

Hippocampus
Prevot TD, Marcotte M, David DJ, Mendez-David I, Mian MY, Cook JM, Guilloux JP, Sibille E.   +7 more
europepmc   +1 more source

Repetitive Transcranial Magnetic Stimulation Induces Cognitive Recovery in Alzheimer's Disease via GABAergic Neuron Activation of the Cx3cl1‐Cx3cr1 Axis

Cell Proliferation, EarlyView.
Schematic diagram illustrating the molecular mechanisms of the Cx3cl1‐Cx3cr1 axis mediated by rTMS activation of GABAergic neurons in the process of cognitive function recovery in AD. ABSTRACT This study aimed to investigate the impact of repetitive transcranial magnetic stimulation (rTMS) on cognitive recovery in Alzheimer's disease (AD) by exploring ...
Yunxiao Kang, Jilun Liu, Yu Wang, Jiaying Wang, Jinyang Wang, Chenming Zhou, Rui Cui, Tianyun Zhang   +7 more
wiley   +1 more source

Dexmedetomidine promotes colorectal cancer progression mediated by gamma-aminobutyric acid signaling. [PDF]

Cancer Metab
Dong J, Wu Y, Che J, He Z, Zhang J.
europepmc   +1 more source

Enhanced GABAergic actions resulting from the coapplication of the steroid 3α-hydroxy-5α-pregnane-11,20-dione (alfaxalone) with propofol or diazepam [PDF]

, 2018
Akk, Gustav, Cao, Lily Q, Chakrabarti, Shampuma, Evers, Alex S, Germann, Allison L, Mennerick, Steven, Montana, Michael C, Shin, Daniel J, Wozniak, David F, Yuede, Carla M   +9 more
core   +1 more source