Results 311 to 320 of about 171,989 (360)
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Neurochemical Research, 1978
Physiologic-pharmacologic studies in vivo and with tissue cultures have revealed that synaptic GABA receptors exist in the vertebrate CNS. The GABA antagonist, bicuculline, can be used to detect synaptic GABA receptors in both the presence and absence of Na+, even though GABA binding to cerebral subcellular fractions occurs mainly to transport (uptake)
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Physiologic-pharmacologic studies in vivo and with tissue cultures have revealed that synaptic GABA receptors exist in the vertebrate CNS. The GABA antagonist, bicuculline, can be used to detect synaptic GABA receptors in both the presence and absence of Na+, even though GABA binding to cerebral subcellular fractions occurs mainly to transport (uptake)
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GABA Receptor molecules of insects
1993Receptors for 4-aminobutyric acid (GABA) have been identified in both central and peripheral nervous systems of several invertebrate phyla. To date, much of the information derived from physiological and biochemical studies on insect GABA receptors relates to GABA-gated chloride channels that show some similarities with vertebrate GABAA receptors. Like
Anthony, N. M. +2 more
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GABA and barbiturate receptors
Trends in Pharmacological Sciences, 1982Abstract Barbiturates potentiate GABA-mediated synaptic transmission in many areas of the CNS. Recent results from studies on the binding of radioactive GABA and phenobarbitone indicate that barbiturates act on a distinct class of receptors to decrease the rate of dissociation of GABA from certain receptors for this major inhibitory transmitter.
Max Willow, Graham A.R. Johnston
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A diversity of GABA receptors in the retina
Seminars in Cell & Developmental Biology, 1998GABA, a major inhibitory transmitter in the vertebrate retina, plays important roles in processing visual information. There are three functional families of retinal GABA receptors, the ionotropic GABAA and GABAC receptors and the metabotropic GABAB receptor. GABAC receptors are enriched in the retina, compared to other parts of the CNS.
Peter D. Lukasiewicz, Colleen R. Shields
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Locating GABA in GABA receptor binding sites
Biochemical Society Transactions, 2009The Cys-loop family of ligand-gated ion channels contains both vertebrate and invertebrate members that are activated by GABA (γ-aminobutyric acid). Many of the residues that are critical for ligand binding have been identified in vertebrate GABAA and GABAC receptors, and specific interactions between GABA and some of these residues have been ...
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2007
γ-Aminobutyric acid (GABA), an amino acid neurotransmitter, is widely distributed throughout the neuraxis. Two pharmacologically and molecularly distinct GABA receptors have been identified, GABAA and GABAB. GABAA receptors are pentameric ligand-gated chloride-ion channels, whereas GABAB receptors are heterodimeric G protein-coupled sites.
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γ-Aminobutyric acid (GABA), an amino acid neurotransmitter, is widely distributed throughout the neuraxis. Two pharmacologically and molecularly distinct GABA receptors have been identified, GABAA and GABAB. GABAA receptors are pentameric ligand-gated chloride-ion channels, whereas GABAB receptors are heterodimeric G protein-coupled sites.
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GABA-receptors in peripheral tissues
Life Sciences, 1990Gamma-aminobutyric acid (GABA) and its receptors are found in a wide range of peripheral tissues, including parts of the peripheral nervous system, endocrines, and non-neural tissues such as smooth muscle and the female reproductive system. In all these, both GABAA- and GABAB-receptor types are found, with good evidence for a physiological role in the ...
Jennifer Ong, David I.B. Kerr
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GABA Receptors and Phospholipids
1978The sodium-independent binding of GABA to certain membrane preparations from rat brain exhibits many of the properties of the interaction of GABA with postsynaptic receptors anticipated from in vivo studies (see papers by Enna and Olsen, this meeting).
S. M. E. Kennedy, Graham A.R. Johnston
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GABA-B Receptors in Drosophila
2010Drosophila melanogaster, the "fruit fly," is being increasingly used as an experimental model in neurosciences, including neuropharmacology. The advantages of Drosophila over typical mammalian models in neuropharmacology include better access to genetic manipulation and the availability of almost unlimited numbers of experimental subjects at relatively
Svetlana Dzitoyeva, Hari Manev
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Nonsynaptic Receptors for GABA and Glutamate
Current Topics in Medicinal Chemistry, 2006The concept of nonsynaptic communication between neurons, once a heretic idea, has become a self-evident fact during the almost forty years since its original discovery. In this review we investigate whether the archetypical synaptic transmitters of the central nervous system, Glu and GABA, can operate via nonsynaptic transmission.
Arpad Mike, E.S. Vizi
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