Results 321 to 330 of about 171,989 (360)
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Bicuculline and Central GABA Receptors
Nature, 1970WE are unable to accept the implication by Krnjevic and his associates1 that we erred in reporting2 bicuculline to be a relatively specific antagonist of γ-aminobutyric acid (GABA) in the central nervous system of the cat.
David R. Curtis +3 more
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GABA and Its Receptors in Epilepsy
2004Gamma-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the mammalian brain. It acts through 2 classes of receptors, GABAA receptors that are ligand-operated ion channels and the G-protein-coupled metabotropic GABAB receptors. Impairment of GABAergic transmission by genetic mutations or application of GABA receptor antagonists ...
Susanne Pirker +3 more
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Presynaptic Ionotropic GABA Receptors
2007Following the classical work on presynaptic inhibition in the spinal cord, recent work has revealed an astonishing abundance and diversity of presynaptic ionotropic GABA receptors. While modern techniques allow for detailed studies at the cellular and molecular level in almost all regions of the CNS, our understanding of the function of such receptors ...
Sergej Kolbaev +2 more
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Benzodiazepine interactions with GABA receptors
Neuroscience Letters, 1984Benzodiazepines (BZs) produce most, if not all, of their pharmacological actions by specifically enhancing the effects of endogenous and exogenous GABA that are mediated by GABAA receptors. This potentiation consists in an increase of the apparent affinity of GABA for increasing chloride conductance without increase in its efficacy and, on the single ...
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2014
Glutamate and GABA receptors are amino acid neurotransmitters present in the central nervous system. They are involved with nociception at multiple levels. Glutamate causes excitation and GABA causes inhibition.
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Glutamate and GABA receptors are amino acid neurotransmitters present in the central nervous system. They are involved with nociception at multiple levels. Glutamate causes excitation and GABA causes inhibition.
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1990
Publisher Summary This chapter focuses on receptors for the neurotransmitter molecule GABA (γ-aminobutyric acid) with particular emphasis on insect GABA receptors. It discusses GABA receptors of the insect nervous system and insect muscle. GABAergic neurons are found in the brain, spinal cord, and ganglia of the mammalian nervous system. Ionophoretic
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Publisher Summary This chapter focuses on receptors for the neurotransmitter molecule GABA (γ-aminobutyric acid) with particular emphasis on insect GABA receptors. It discusses GABA receptors of the insect nervous system and insect muscle. GABAergic neurons are found in the brain, spinal cord, and ganglia of the mammalian nervous system. Ionophoretic
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Interaction of Steroids with the GABA-A Receptor
Current Topics in Medicinal Chemistry, 2002Over the last two decades there has been a resurgence of interest in steroids as potential therapeutics for central nervous system disorders. This interest followed the discovery that neurosteroids and neuroactive steroids are potent modulators of GABA(A) receptor function.
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2016
GABAergic neurons including Purkinje cells play critical roles in cerebellar neuronal circuits. In the cerebellar cortex, molecular layer interneurons (stellate and basket cells) provide feedforward inhibitory loops between parallel fibers and Purkinje cells, and granular layer interneurons (Golgi cells) form feedback inhibition loops between granule ...
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GABAergic neurons including Purkinje cells play critical roles in cerebellar neuronal circuits. In the cerebellar cortex, molecular layer interneurons (stellate and basket cells) provide feedforward inhibitory loops between parallel fibers and Purkinje cells, and granular layer interneurons (Golgi cells) form feedback inhibition loops between granule ...
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Annals of the New York Academy of Sciences, 1990
Peter C. Waldmeier, P. A. Baumann
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Peter C. Waldmeier, P. A. Baumann
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