Results 81 to 90 of about 171,989 (360)

Wireless In Situ Catalytic Electron Signaling‐Mediated Transcriptomic Reprogramming for Neuron Regeneration via Adaptable Antennas

Advanced Science, EarlyView.
A wireless‐charging sustained oxygen release from conductive microgels (SOCO) served as an antenna and an on‐demand O2 release for nerve regeneration is developed. Introducing “electromagnetic messenger”, using external alternating magnetic field (AMF) to enhance catalytic oxygen release and electrical stimulation to promote the reconstruction of blood
Hoi Man Iao, Chih‐Ying Chen, Ya‐Hui Lin, Wan‐Chi Pan, Chun‐Yi Liang, Hsiu‐Ching Liu, Lo‐Jei Ching, Pei‐Yu Weng, Min‐Ren Chiang, Ru‐Siou Hsu, Tsu‐Chin Chou, I‐Chi Lee, Lun‐De Liao, Li‐An Chu, Shih‐Hwa Chiou, Shang‐Hsiu Hu   +15 more
wiley   +1 more source

In intact islets interstitial GABA activates GABA(A) receptors that generate tonic currents in α-cells. [PDF]

PLoS ONE, 2013
In the rat islets γ-aminobutyric acid (GABA) is produced by the β-cells and, at least, the α-cells express the GABA(A) receptors (GABA(A) channels). In this study, we examined in intact islets if the interstitial GABA activated the GABA(A) receptors.
Yang Jin, Sergiy V Korol, Zhe Jin, Sebastian Barg, Bryndis Birnir   +4 more
doaj   +1 more source

An Amygdala‐hippocampus Circuit for Endocannabinoid Modulation of Anxiety Avoidance

Advanced Science, EarlyView.
This study employs three synapse‐specific endocannabinoids (eCB) probes to monitor dynamic eCB release, activate CB1Rs and knockdown 2‐AG biosynthesis enzymes in glutamatergic anterior basolateral amygdala ‐ ventral hippocampus (aBLA–vHPC) circuit. At aBLA–vHPC circuits, activation of CB1Rs reduce anxiety avoidance, and knockdown of eCB biosynthesis ...
Bao Xue, Mao‐Xing Zhang, Xiao‐Chen Bi, Shou‐Peng Lai, Xin‐Tian Bie, Yuan Dong, Jian‐Feng Li, Fang Gao, Xia Zhang, Ying Wang   +9 more
wiley   +1 more source

Role of GABA receptors in fetal lung development in rats. [PDF]

PLoS ONE, 2010
Fluid accumulation is critical for lung distension and normal development. The multi-subunit γ-amino butyric acid type A receptors (GABAA) mainly act by mediating chloride ion (Cl-) fluxes.
Narendranath Reddy Chintagari, Nili Jin, Li Gao, Yang Wang, Dong Xi, Lin Liu   +5 more
doaj   +1 more source

Interaction of GABA and Excitatory Amino Acids in the Basolateral Amygdala: Role in Cardiovascular Regulation [PDF]

, 1997
Activation of the amygdala in rats produces cardiovascular changes that include increases in heart rate and arterial pressure as well as behavioral changes characteristic of emotional arousal.
Cook, Jennifer C., Gregg, Adam E., Sanders, Brian J., Soltis, Robert P.   +3 more
core   +2 more sources

Engineering Adenine Deaminase TadA for Precise and PAM‐Flexible Point Mutagenesis and Gradient‐Tuning Endogenous Protein Design

Advanced Science, EarlyView.
Base editing enables precise nucleotide substitutions but limited by bystander editing. This study engineers plant base editors by fusing optimized TadA variants with PAM‐flexible SpRY nickase, enabling A‐to‐G, C‐to‐T, and dual‐base conversions in a highly condensed window (≤3 nucleotides). Additionally, TadDBE (TadA Dual‐Base Editor)‐mediated directed
Kangli Sun, Si Cheng, Nan Chai, Jianing Mi, Ruixiang Zhang, Qian Qian, Zhiye Zheng, Ke Chen, Dongchang Zeng, Xin Peng, Mengyuan Shen, Degui Zhou, Qinlong Zhu, Qi Liu, Jiantao Tan   +14 more
wiley   +1 more source

Ethanol activation of protein kinase A regulates GABA-A receptor subunit expression in the cerebral cortex and contributes to ethanol-induced hypnosis

Frontiers in Neuroscience, 2012
Protein kinases are implicated in neuronal cell functions such as modulation of ion channel function, trafficking and synaptic excitability. Both protein kinase C (PKC) and A (PKA) are involved in regulation of γ-aminobutyric acid type A (GABA-A ...
Sandeep eKumar, Qinglu eRen, Jonathan eBeckley, Todd eO'Buckley, Eduardo eGigante, Jessica eSanterre, David F Werner, A Leslie eMorrow   +7 more
doaj   +1 more source

GABA Receptors and the Pharmacology of Sleep

, 2017
Current GABAergic sleep-promoting medications were developed pragmatically, without making use of the immense diversity of GABAA receptors. Pharmacogenetic experiments are leading to an understanding of the circuit mechanisms in the hypothalamus by which zolpidem and similar compounds induce sleep at α2βγ2-type GABAA receptors.
Wisden, W, Yu, X, Franks, NP
openaire   +5 more sources

The cumulative analgesic effect of repeated electroacupuncture is modulated by Adora3 in the SCDH of mice with neuropathic pain

Animal Models and Experimental Medicine, EarlyView.
Neuropathic pain management via repeated electroacupuncture. Abstract Background Existing remedial approaches for relieving neuropathic pain (NPP) are challenging and open the way for alternative therapeutic measures such as electroacupuncture (EA). The mechanism underlying the antinociceptive effects of repeated EA sessions, particularly concerning ...
Faisal Ayub Kiani, Hao Li, Panpan Guo, Qiulin Zhang, Mahmoud M. Abouelfetouh, Mingxing Ding, Yi Ding   +6 more
wiley   +1 more source

Selective loss of GABAB receptors in orexin/hypocretin-producing neurons results in disrupted sleep/wakefulness architecture [PDF]

, 2007
We generated mice with a selective loss of GABAB receptors in orexin neurons. Orexin neurons in these GABAB1^-/-(orexin) mice showed reduced responsiveness to GABA_A receptor agonists due to a ...
Bernard Bettler, Hitomi Takahira, Ken-ichi Yagami, Masashi Yanagisawa, Mika Nomiyama, Noriko Hirashima, Satoru Takahashi, Satoshi Kunita, Taizo Matsuki, Takeshi Sakurai, Thomas Kilduff   +10 more
core   +1 more source