Results 111 to 120 of about 2,290,618 (347)

Cancer Stem Cells are Depolarized Relative to Normal Stem Cells Derived from Human Livers

Annals of Hepatology, 2017
Introduction and aim. The inability to distinguish cancer (CSCs) from normal stem cells (NSCs) has hindered attempts to identify safer, more effective therapies for hepatocellular carcinoma (HCC).
Wendy Bautista, Jeremy Lipschitz, Andrew McKay, Gerald Y. Minuk   +3 more
doaj  

Segregation of acetylcholine and GABA in the rat superior cervical ganglia: functional correlation.

Frontiers in Cellular Neuroscience, 2016
Sympathetic neurons have the capability to segregate their neurotransmitters (NTs) and co-transmitters to separate varicosities of single axons; furthermore, in culture, these neurons can even segregate classical transmitters. In vivo sympathetic neurons
Diana eElinos, Raúl eRodríguez, Luis Andres Martínez, María Elena Zetina, Fredy eCifuentes, Miguel Angel Morales   +5 more
doaj   +1 more source

Successful seizure control with cenobamate in juvenile myoclonic epilepsy

Epileptic Disorders, EarlyView.
Dalma Tényi, Réka Horváth, József Janszky   +2 more
wiley   +1 more source

Peripheral-Type Benzodiazepine Receptor Antagonist Is Effective in Relieving Neuropathic Pain in Mice

Journal of Pharmacological Sciences, 2009
.: cDNA microarray analysis showed the expression of peripheral-type benzodiazepine receptor (PBR) mRNA is slightly enhanced in the spinal cord of mice with spinal nerve injury (SNL) as compared with sham-operated mice.
Daisuke Kondo, Hironao Saegusa, Ritsuko Yabe, Ichiro Takasaki, Takashi Kurihara, Shuqin Zong, Tsutomu Tanabe   +6 more
doaj  

Increased motor-impairing effects of the neuroactive steroid pregnanolone in mice with targeted inactivation of the GABAA receptor gamma2 subunit in the cerebellum

Frontiers in Pharmacology, 2016
Endogenous neurosteroids and neuroactive steroids have potent and widespread actions on the brain via inhibitory GABAA receptors. In recombinant receptors and genetic mouse models their actions depend on the alpha, beta and delta subunits of the receptor,
Elli Leppä, Anni-Maija Tuulikki Linden, M. Isabel Aller, Peer Wulff, Olga Vekovischeva, Bernhard Lüscher, Hartmut Lüddens, William Wisden, Esa R Korpi   +8 more
doaj   +1 more source

Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal.

Journal of Clinical Investigation, 2012
Glyoxalase 1 (Glo1) expression has previously been associated with anxiety in mice; however, its role in anxiety is controversial, and the underlying mechanism is unknown.
Margaret G. Distler, L. Plant, G. Sokoloff, A. Hawk, I. Aneas, G. Wuenschell, J. Termini, S. Meredith, Marcelo Araujo da Nóbrega, A. Palmer   +9 more
semanticscholar   +1 more source

Generation of recombinant antibodies to rat GABAA receptor subunits by affinity selection on synthetic peptides.

PLoS ONE, 2014
The abundance and physiological importance of GABAA receptors in the central nervous system make this neurotransmitter receptor an attractive target for localizing diagnostic and therapeutic biomolecules.
Sujatha P Koduvayur, Hélène A Gussin, Rajni Parthasarathy, Zengping Hao, Brian K Kay, David R Pepperberg   +5 more
doaj   +1 more source

Steroid Receptors and Vertebrate Evolution [PDF]

arXiv, 2019
Considering that life on earth evolved about 3.7 billion years ago, vertebrates are young, appearing in the fossil record during the Cambrian explosion about 542 to 515 million years ago. Results from sequence analyses of genomes from bacteria, yeast, plants, invertebrates and vertebrates indicate that receptors for adrenal steroids (aldosterone ...
arxiv  

Lack of tolerance to the separate or combined hypnotic actions of different partitions of Melissa officinalis (total, ethyl acetate, and aqueous) and methanolic partition of Albizia julibrissin

JSFA reports, EarlyView.
Abstract Objective The present study investigates the hypnotic action of the methanolic partition of Albizia julibrissin (MPAJ) and various partitions (total, ethyl acetate, and aqueous) of Melissa officinalis (MO) in mice. Methods Pentobarbital‐induced sleep (PIS) time prolongation was used to assess the hypnotic action of test compounds.
Mahshid Rashidi, Masoud Sadeghi‐Dinani, Mohammad Rabbani   +2 more
wiley   +1 more source

Kinetic properties of the GABAA receptor main conductance state of mouse spinal cord neurones in culture. [PDF]

, 1989
Robert L. Macdonald, Connie J. Rogers, Roy E. Twyman   +2 more
openalex   +1 more source