Results 111 to 120 of about 41,401 (221)

Population Pharmacokinetic–Pharmacodynamic Analysis of Zolpidem in Healthy Volunteers: Covariate Contributions to Variability in CNS Responses

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.
ABSTRACT Population pharmacokinetic–pharmacodynamic (PK–PD) modeling was used to explore covariate effects on zolpidem PKs and PDs in 30 healthy Korean volunteers (15 males, 15 females) who received a single 10 mg dose. The dataset included 325 PK observations and 388 observations each for the digit symbol substitution test (DSST), choice reaction time
Hyun Chul Kim, Jung Sunwoo, Seonghae Yoon, In‐Jin Jang, Jae‐Yong Chung   +4 more
wiley   +1 more source

Engaging Gut‐to‐Brain Signalling to Treat Alcohol Use Disorder

Addiction Biology, Volume 31, Issue 3, March 2026.
ABSTRACT According to the 2023 National Survey on Drug Use and Health (NSDUH), 28.9 million people ages 12 and older in the United States had alcohol use disorder (AUD) in the past year. Although chronic alcohol use contributes to numerous health disorders as well as being an economic burden, there are few medications approved for treatment of AUD, and
Paula L. Hoffman, Giordano de Guglielmo, Valentina Vengeliene, Wolfgang Kunze, Christina L. Lebonville, Jerome D. Swinny, Amanda J. Roberts, Olivier George, Karen‐Anne McVey Neufeld, Alexandra Dunbar, Laura M. Saba, Ruolin Ma, Leandro F. Vendruscolo, Howard C. Becker, Rainer Spanagel, Boris Tabakoff   +15 more
wiley   +1 more source

Electrophysiological sexual dimorphism as an early risk marker of alcohol use in adolescence: A longitudinal neuroimaging study

Addiction, Volume 121, Issue 3, Page 606-616, March 2026.
Abstract Aims To identify the brain activity profiles associated with alcohol consumption and to address its causes. Furthermore, we sought to examine the relationship between these electrophysiological markers and the excitation–inhibition balance, as well as to explore the potential moderating role of sex in these associations.
Alberto del Cerro‐León, Marcos Uceta, Danylyna Shpakivska‐Bilan, Isabel Suárez‐Méndez, Héctor Peribáñez‐Baz, Pablo Cuesta, Ricardo Bruña, Luis M. García‐Moreno, Fernando Maestú, Luis Fernando Antón‐Toro   +9 more
wiley   +1 more source

Ethanol-Withanolides Interactions: Compound-Specific Effects on Zebrafish Larvae Locomotor Behavior and GABAA Receptor Subunit Expression. [PDF]

Int J Mol Sci
Czora-Poczwardowska K, Kujawski R, Jarczak W, Cicha E, Mikołajczak P, Szulc M.   +5 more
europepmc   +1 more source

Impact of long‐term treatment with cenobamate on concomitant usage of antiseizure medications: A real‐world retrospective study in Spain

Epilepsia, Volume 67, Issue 3, Page 1221-1234, March 2026.
Abstract Objectives This study explored the safety and effectiveness of adjunctive cenobamate (CNB) in patients with different levels of drug‐resistant epilepsy (DRE) in a real‐world setting, including its impact on the use of co‐antiseizure medication (co‐ASM). Methods This was a single‐center, retrospective, observational study.
Juan María Sánchez‐Caro, Roshan Hariramani Ramchandani, Iratxe Maestro Saiz, Juan Jesús Rodríguez Uranga   +3 more
wiley   +1 more source

Progress in GABAA receptor agonists for insomnia disorder. [PDF]

Front Pharmacol
Wang W, Fu W, Zhu H, Ma J, Zhang J, Qi J.   +5 more
europepmc   +1 more source

Spreading depolarization and its influence on epileptiform activity

Epilepsia, Volume 67, Issue 3, Page 1078-1089, March 2026.
Abstract Spreading depolarization (SD) is a transient disruption of electrographic activity that slowly propagates through the gray matter by chemical contiguity, and it is characterized by a large depolarization of neurons and glial cells. SD, which is associated with massive changes in ion homeostasis, including extreme increases in [K+]o, was shown ...
Maxime Lévesque, Rüdiger Köhling, Massimo Avoli   +2 more
wiley   +1 more source

Neuronal hyperexcitability: A key to unraveling hippocampal synaptic dysfunction in Lafora disease

Epilepsia, Volume 67, Issue 3, Page 1449-1468, March 2026.
Abstract Background and Objective Lafora disease (LD) is a rare progressive disorder caused by mutations in the EPM2A or EPM2B genes, characterized by the accumulation of Lafora bodies, drug‐resistant epilepsy, and cognitive decline. To investigate the early molecular mechanisms of LD, we studied electrophysiological changes in the dentate gyrus (DG ...
Cinzia Costa, Laura Bellingacci, Jacopo Canonichesi, Valentina Imperatore, Anna Aurora Taddei, Luis Zafra‐Puerta, Nerea Iglesias‐Cabeza, Paolo Prontera, Andrea Mancini, Massimiliano Di Filippo, Alessandro Tozzi, Katiuscia Martinello, Marta Barzasi, Fabrizio Gardoni, Marina P. Sánchez, José M. Serratosa, Lucilla Parnetti, Miriam Sciaccaluga   +17 more
wiley   +1 more source

Improving Proteostasis of Trafficking-Deficient GABA_A Receptor Variants by Activating IRE1. [PDF]

ACS Chem Neurosci
Fu X, Wang YJ, Lee K, Ahn LY, Chen X, Harvey BT, Wang M, Seibert H, Zhang PP, Guerrero A, Schaffer AE, Richards CI, Wiseman RL, Kelly JW, Mu TW.   +14 more
europepmc   +1 more source

Prefrontal Cortex Dysfunction as a Precipitating Factor for Schizophrenia and Depression

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
Stress during adolescence or adulthood affects the ability of the prefrontal cortex (PFC) to adaptively regulate stress. Maladaptive adult stress leads to PFC hypofunction and a hypodopaminergic state in the medial, affect‐related ventral tegmental area (VTA), resulting in amotivation.
Daniela L. Uliana, Anthony A. Grace
wiley   +1 more source