Results 101 to 110 of about 1,383 (171)

The Effect of Remimazolam Administration on Emergence Delirium in Children After General Anesthesia: A Systematic Review With Meta‐Analysis of Randomized Controlled Trials

Pediatric Anesthesia, Volume 36, Issue 6, Page 628-640, June 2026.
ABSTRACT Background Emergence delirium commonly occurs in pediatric patients after general anesthesia, causing distress and potential harm. Remimazolam, an ultra‐short‐acting benzodiazepine, has recently been introduced in pediatric anesthesia, but its preventive role against emergence delirium remains unclear.
Ji‐Na Kim, Hyo‐Seok Na, Hyun‐Jung Shin   +2 more
wiley   +1 more source

Functional analysis of epilepsy‐associated GABAA receptor mutations using Caenorhabditis elegans

Epilepsia Open
Objective GABAA receptor subunit mutations pose a significant risk for genetic generalized epilepsy; however, there are over 150 identified variants, many with unknown or unvalidated pathogenicity.
Ami Gadhia, Eleanor Barker, Alan Morgan, Jeff W. Barclay   +3 more
doaj   +1 more source

Dystrophinopathy with a DMD exon 49–50 deletion in a female patient who developed schizophrenia: An autopsy case

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.
Abstract Background Mutations in DMD affect not only muscles but also the brain. Cases of schizophrenia with DMD mutations have been described previously. Although female dystrophinopathy often has a milder phenotype, some affected females also have intellectual disabilities and psychiatric disorders.
Shusei Arafuka, Youta Torii, Ayako Miwa, Itaru Kushima, Hirotaka Sekiguchi, Hiroshige Fujishiro, Chikako Habuchi, Hiroaki Miyahara, Yosuke Kawai, Ran Wei, Katsushi Tokunaga, Norio Ozaki, Mari Yoshida, Shuji Iritani, Yasushi Iwasaki, Masashi Ikeda   +15 more
wiley   +1 more source

Formulation and Pharmacological Evaluation of a Medicine‐Food Homology Herb‐Based Formula for Sleep Enhancement

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
This outlines the progress for developing a sleep‐modulating herbal formula (SMF). It begins with the identification of effective compounds and quality control, then uses network pharmacology and molecular docking to explain the mechanisms behind the observation found on the behavioural and neurobiological results in animal study.
Jasmine U. Ting, Chunxue Zhao, Jia Xu, Chenrui Liu, Yungang Tian, Min Ye, Tao Cui, Jian Huang   +7 more
wiley   +1 more source

Behavioral Domain‐Specific Effects of Positive Modulation of α5 and α6 GABAA Receptors in a Rat Double‐Hit Stress Model

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
A double‐hit stress model in Sprague–Dawley rats induces alterations in motivation, motor impulsivity, and social recognition that are partially ameliorated by α5‐ and α6‐GABAA receptor modulation, suggesting domain‐specific effects of this modulation on the stress‐induced phenotype. ABSTRACT Impulsivity is an understudied area of post‐traumatic stress
Đorđe Đorović, Jovana Aranđelović, Jana Ivanović, Kristina Jezdić, Bojan Batinić, Dishary Sharmin, Prithu Mondal, James M. Cook, Miroslav M. Savić   +8 more
wiley   +1 more source

Investigating the Phytochemical Constituents, Anti‐Inflammatory, and Neuropharmacological Activities of Podocarpus neriifolius Leaves Through FT‐IR, GC–MS, Experimental Studies, Molecular Docking, and Molecular Dynamics Simulations

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Podocarpus neriifolius, a widely distributed medicinal plant in South and Southeast Asia, has traditionally been used to treat rheumatism and joint pain. This study aimed to investigate the phytochemical profile and therapeutic potential of the ethanolic leaf extract of P.
Neamul Hoque, Md. Tashrif Rahman Tipu, Md Abul Bashar, Raju Dash, Kutub Uddin Ahamed, Md. Liakot Ali, Md. Jahirul Islam Mamun, Bakul Akter, Mohammed Kamrul Hossain, Nawreen Monir Proma   +9 more
wiley   +1 more source

Maternal Intake of Dipteryx alata Vog. Reduces Offspring's Brain Oxidative Stress and Anxiety: Insights From In Silico and In Vivo Studies

Journal of Food Science, Volume 91, Issue 6, June 2026.
ABSTRACT We undertook a computational investigation and evaluation of the impact of maternal supplementation with baru almonds (Dipteryx alata Vog.) on anxiety‐like behavior and oxidative stress in the brains of adolescent and adult rat offspring. Molecular docking studies were conducted and revealed that the phenolic compounds (PCs) from the baru ...
Diego Elias Pereira, Rita de Cássia de Araújo Bidô, Maciel da Costa Alves, Renally de Lima Moura, Ana Carolina dos Santos Costa, Larissa Maria Gomes Dutra, Louis Gustavo da Costa Sobral e Sá, Vanessa Bordin Viera, Jaqueline Ferreira Ramos, Juliano Carlo Rufino Freitas, Daline Fernandes de Araújo, Gerlane Coelho Bernardo Guerra, Juliana Késsia Barbosa Soares   +12 more
wiley   +1 more source

Ca2+‐Activated Cl− Channels: Do Bestrophins and TMEM16A Interact?

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim Ca2+‐activated Cl– conductances are present in many cell types and are important for regulating membrane potential as well as other cellular functions. TMEM16A is widely accepted as the principal molecular basis for Ca2+‐activated Cl– conductances, but also members of the bestrophin family may be important for some Ca2+‐activated Cl ...
Christian Aalkjær, Vibeke Secher Dam, Holger Nilsson, Donna B. Boedtkjer, Vladimir Matchkov   +4 more
wiley   +1 more source

The Long Haul: Microtubule Motors as the Essential Supply Line for Neuronal Longevity

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
To survive a lifetime, neurons depend on a high‐fidelity logistics network powered by microtubule motors. We explore how a broad spectrum of genetic defects in this machinery drive a devastating spectrum of neurodevelopmental and neurodegenerative diseases, including Hereditary Spastic Paraplegia (HSP), Charcot–Marie‐Tooth Type 2 (CMT2), and ...
Emma D. Turner, Alison E. Twelvetrees
wiley   +1 more source

NMDA and glycine receptors provide dual presynaptic regulation on climbing fibre inputs to cerebellar Purkinje cells

The Journal of Physiology, Volume 604, Issue 12, Page 4926-4944, 15 June 2026.
Abstract figure legend Vibrodissociated Pukinje neurons retain active synaptic connections, including those from adhering fragments of the climbing fibre. These fragments generate excitatory synaptic events and the frequency of these events is increased by exposure to either NMDA [with d‐serine (d‐ser) as a co‐agonist] or glycine at a high (100 µM ...
David C. H. Benton, Alan D. Robertson, Matthew Caldwell, Yuriy Pankratov, Lema Imam, Trevor G. Smart, Gareth Morris, Guy W. J. Moss   +7 more
wiley   +1 more source