Results 111 to 120 of about 1,383 (171)

The endogenous cannabinoid system gates plasticity of tonic GABA inhibition

The Journal of Physiology, Volume 604, Issue 12, Page 4984-5010, 15 June 2026.
Abstract figure legend Postsynaptic depolarisation and increases in intracellular Ca2+ ([Ca2+]i) trigger the synthesis of endocannabinoids (eCBs), which are hypothesised to enhance tonic GABAergic inhibition via two primary pathways. In the proposed autocrine mechanism, eCBs activate postsynaptic somatodendritic or mitochondrial CB1 receptors ...
Roberto Colangeli, Fiorenzo Conti
wiley   +1 more source

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Epilepsia Open, Volume 11, Issue 3, Page 683-691, June 2026.
wiley   +1 more source

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An update on GABAA receptors

Brain Research Reviews, 1999
Recent advances in molecular biology and complementary information derived from neuropharmacology, biochemistry and behavior have dramatically increased our understanding of various aspects of GABAA receptors. These studies have revealed that the GABAA receptor is derived from various subunits such as alpha1-alpha6, beta1-beta3, gamma1-gamma3, delta ...
A K, Mehta, M K, Ticku
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Pharmacological modulation of GABAA receptors

Current Opinion in Pharmacology, 2021
Ligand-gated ion channels are integral membrane proteins that activate through a change in conformation upon transmitter binding and were identified as key players of brain function. GABAA receptors are major inhibitory ligand-gated ion channels of this protein family.
Frédéric, Knoflach, Daniel, Bertrand
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Molecular Biology of the GABAA Receptor

1988
The GABAA receptorreceptor is the major molecular site of the ubiquitous inhibitory acEivities of the brain, being present on the great majority of mammalian brain neurones (1). Electrophysiological studies and, especially, recent patch-clamp studies on cultured neurones (2,3) have established that at these sites GABA opens a chloride channel which is ...
Barnard, E., Darlison, M., Fujita, N., Glencorse, T., Levitan, E., Reale, V., Schofield, P., Seeburg, P., Squire, M., Stephenson, A.   +9 more
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Neurosteroids and GABAA receptor function

Trends in Pharmacological Sciences, 1995
In 1984, a potent and selective interaction of the steroidal anaesthetic alphaxalone with the GABAA receptor was demonstrated. Subsequent studies established that certain naturally occurring steroids were potent positive allosteric modulators of the GABAA receptor.
Lambert, Jeremy J., Belelli, Delia, Hill-Venning, Claire, Peters, John A.   +3 more
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The GABAA Receptors

1996
Transmitter-gated ion channels are multisubunit membrane-spanning receptors that serve as rapid signal transduction devices regulating the flow of cations or anions through the cell membrane. Cell type—specific flexibility in neurotransmission is accomplished by a multiplicity of channel variants based on the combinatorial assembly of structurally ...
H. Mohler, J. M. Fritschy, B. Lüscher, U. Rudolph, J. Benson, D. Benke   +5 more
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Neurosteroid modulation of GABAA receptors

Progress in Neurobiology, 2003
Certain metabolites of progesterone and deoxycorticosterone are established as potent and selective positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor. Upon administration these steroids exhibit clear behavioural effects that include anxiolysis, sedation and analgesia, they are anticonvulsant and at high doses ...
Lambert, Jeremy J., Belelli, Delia, Peden, Dianne R., Vardy, Audrey W., Peters, John A.   +4 more
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Cyclothiazide binding to the GABAA receptor

Neuroscience Letters, 2008
In order to explore the molecular interaction between cyclothiazide (CTZ) and gamma-aminobutyric acidA (GABAA) receptors, possibly underlying inhibition of GABAA receptor currents, [3H]-CTZ was synthesized. Binding of [3H]-CTZ to rat brain synaptic membranes could be observed only in the presence of the GABAA receptor antagonist (-)[1S,9R]-bicuculline ...
Eva, Szárics, Agnes, Simon, Júlia, Visy, Edit, Simon-Trompler, Zoltán, Banka, László, Héja, László Gábor, Hársing, Gábor, Blaskó, Julianna, Kardos   +8 more
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Molecular Neurobiology of the GabaA Receptor

1994
Publisher Summary This chapter discusses the molecular neurobiology of the GABAA receptor. The GABAA receptor is responsible for the majority of neuronal inhibition in the vertebrate CNS. The ubiquitous distribution of the GABAA receptor in the mammalian CNS is revealed by the use of [3H]GABA radioligand binding techniques, whereas autoradiographic ...
S M, Dunn, A N, Bateson, I L, Martin
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