Results 151 to 160 of about 80,549 (314)

Impaired Volume Regulation and Electrophysiology of Astrocytes In Situ in a Mouse Model for Megalencephalic Leukoencephalopathy With Subcortical Cysts

Glia, Volume 73, Issue 9, Page 1899-1909, September 2025.
Main Points Cell culture studies show disrupted astrocyte physiology in the leukodystrophy MLC. Are intact astrocytes similarly affected? This study on astrocytes in MLC mouse brain slices confirms and extends in vitro studies on altered astrocyte physiology.
Sven Kerst, Nina Meesters, Tim S. Heistek, Marjo S. van der Knaap, Huibert D. Mansvelder, Rogier Min   +5 more
wiley   +1 more source

Cloning of GABAA/benzodiazepine receptor subunit cDNAs

, 1987
N Fujita, David Burt, MG Darlison, T. Gleneorse, Anne Stephenson, E.A. Barnard, Peter W. Schofield, P. H. Seeburg, Henrique Rodrigues, J. Ramachandran   +9 more
openalex   +1 more source

Propofol: A Medication That Changed Pediatric Anesthesia Practice

Pediatric Anesthesia, Volume 35, Issue 9, Page 695-706, September 2025.
ABSTRACT The introduction of propofol changed our understanding of pediatric anesthesia pharmacology, research approaches for intravenous drug study, and led to infusion pump development for the maintenance phase of anesthesia. The story of propofol development provides a blueprint for other intravenous drug development.
Brian J. Anderson, L. Ignacio Cortinez
wiley   +1 more source

Neurochemical studies on γ-aminobutyric acid(GABA) receptor.(XV) Pharmacological properties of purified GABAA/benzodiazepine receptor complex from bovine cerebral cortex and its co-purification with [35S]t-butylbicyclophosphorothionate binding site by benzodiazepine affinity column chromatography

, 1986
Junichi Taguchi, Kinya Kuriyama
openalex   +1 more source

Laminar Distribution of GABAA Receptor 1, 2, and 2 Subunit mRNAs in the Granular and Agranular Frontal Cortex of the Rat during Pre- and Postnatal Development [PDF]

, 1995
Corbert G. van Eden, R. Parmar, W. Lichtensteiger, M. Schlumpf   +3 more
openalex   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, Volume 12, Issue 29, August 7, 2025.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Modulation of GABAA receptor-activated current by norepinephrine in cerebellar purkinje cells

, 1992
J.E. Cheun, Hermes H. Yeh
openalex   +1 more source

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, Volume 12, Issue 29, August 7, 2025.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source

Astroglial CB1 Reveal Sex‐Specific Synaptic Effects of Amphetamine

Glia, Volume 73, Issue 8, Page 1673-1691, August 2025.
Main Points Astroglial CB1 mediate long‐term depression in the NAc through purine release. Amphetamine occludes LTD in male mice by inducing the saturation of A1 receptors. Astroglial CB1 mediate behavioral amphetamine effects in males, but not in females.
Yamuna Mariani, Tommaso Dalla‐Tor, Tommaso Garavaldi, Francisca Julio‐Kalajzić, Doriane Gisquet, Paula Gomez‐Sotres, Astrid Cannich, Giuditta Gambino, Filippo Drago, Roman Serrat, Imane Hurel, Francis Chaouloff, Sandrine Pouvreau, Luigi Bellocchio, Giovanni Marsicano, Ana Covelo   +15 more
wiley   +1 more source

MRI Characteristics of Autoimmune Encephalitis With Autoantibodies to GABAA Receptor: A Case Series. [PDF]

Neurol Neuroimmunol Neuroinflamm, 2022
Deng B, Cai M, Qiu Y, Liu X, Yu H, Zhang X, Huang H, Zhao X, Yang W, Dong S, Jin L, Chu S, Chen X.   +12 more
europepmc   +2 more sources