Results 171 to 180 of about 41,401 (221)
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Trends in Neurosciences, 1996
In a recent issue, a review addressed the important question of which GABAA-receptor subtypes occur in our brain1xMcKernan, R.M. and Whiting, P.J. Trends Neurosci. 1996; 19: 139–143Abstract | Full Text PDF | PubMed | Scopus (939)See all References1.
Erwin Sigel, Kai Kannenberg
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In a recent issue, a review addressed the important question of which GABAA-receptor subtypes occur in our brain1xMcKernan, R.M. and Whiting, P.J. Trends Neurosci. 1996; 19: 139–143Abstract | Full Text PDF | PubMed | Scopus (939)See all References1.
Erwin Sigel, Kai Kannenberg
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Neurosteroids and GABAA receptor function
Trends in Pharmacological Sciences, 1995In 1984, a potent and selective interaction of the steroidal anaesthetic alphaxalone with the GABAA receptor was demonstrated. Subsequent studies established that certain naturally occurring steroids were potent positive allosteric modulators of the GABAA receptor.
Lambert, Jeremy J. +3 more
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1996
Transmitter-gated ion channels are multisubunit membrane-spanning receptors that serve as rapid signal transduction devices regulating the flow of cations or anions through the cell membrane. Cell type—specific flexibility in neurotransmission is accomplished by a multiplicity of channel variants based on the combinatorial assembly of structurally ...
H. Mohler +5 more
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Transmitter-gated ion channels are multisubunit membrane-spanning receptors that serve as rapid signal transduction devices regulating the flow of cations or anions through the cell membrane. Cell type—specific flexibility in neurotransmission is accomplished by a multiplicity of channel variants based on the combinatorial assembly of structurally ...
H. Mohler +5 more
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Multiplicity of GABAA-benzodiazepine receptors
Trends in Pharmacological Sciences, 1989Binding studies suggest the presence of at least two pharmacologically distinct 'central' benzodiazepine receptors in the brain. Since central benzodiazepine receptors are allosteric modulatory sites on GABAA receptors, this evidence indirectly points to the existence of at least two GABAA receptors.
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Molecular Biology of the GABAA Receptor
1988The GABAA receptorreceptor is the major molecular site of the ubiquitous inhibitory acEivities of the brain, being present on the great majority of mammalian brain neurones (1). Electrophysiological studies and, especially, recent patch-clamp studies on cultured neurones (2,3) have established that at these sites GABA opens a chloride channel which is ...
Barnard, E. +9 more
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2001
Studies of human diseases of the nervous system have demonstrated that many of the disorders result from disruption of normal developmental processes which promote organization and maturation of neuronal circuitry. Such disorders include many different forms of inherited childhood epilepsies in which genetic factors contribute to the abnormal ...
H. Y. Kim, R. W. Olsen
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Studies of human diseases of the nervous system have demonstrated that many of the disorders result from disruption of normal developmental processes which promote organization and maturation of neuronal circuitry. Such disorders include many different forms of inherited childhood epilepsies in which genetic factors contribute to the abnormal ...
H. Y. Kim, R. W. Olsen
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