Results 191 to 200 of about 2,290,618 (347)

A single histidine in GABAA receptors is essential for benzodiazepine agonist binding.

, 1992
H. Wieland, Hartmut Lüddens, P. H. Seeburg   +2 more
openalex   +1 more source

Assessment of Sedative Activity of Lonicerin: In Vivo Approach With Pharmacokinetics and Molecular Docking

Brain and Behavior, Volume 15, Issue 5, May 2025.
Lonicerin (LON) at doses of 5 and 10 mg/kg reduced sleep latency and increased sleep duration in mice, with combined LON and diazepam showing maximal effects. Computational docking showed LON binds to GABAA receptor sites with a strong affinity (−8.1 kcal/mol), suggesting potential as an insomnia treatment. ABSTRACT Background: Lonicerin (LON) has been
Tanzila Akter Eity, Md. Shimul Bhuia, Raihan Chowdhury, Salehin Sheikh, Siddique Akber Ansari, Nowreen Tabassum Ahammed, Hossam Kamli, Muhammad Torequl Islam   +7 more
wiley   +1 more source

Progress in GABAA receptor agonists for insomnia disorder. [PDF]

Front Pharmacol
Wang W, Fu W, Zhu H, Ma J, Zhang J, Qi J.   +5 more
europepmc   +1 more source

Effects of Pulsatile Infusion of the GABAA Receptor Blocker Bicuculline on the Onset of Puberty in Female Rhesus Monkeys1 [PDF]

, 1999
Kim L. Keen, Andrew J. Burich, Dai Mitsushima, Etsuko Kasuya, Ei Terasawa   +4 more
openalex   +1 more source

Role of Glutamate Excitotoxicity in Glioblastoma Growth and Its Implications in Treatment

Cell Biology International, Volume 49, Issue 5, Page 421-434, May 2025.
ABSTRACT Glioblastoma is a highly malignant and invasive type of primary brain tumor that originates from astrocytes. Glutamate, a neurotransmitter in the brain plays a crucial role in excitotoxic cell death. Excessive glutamate triggers a pathological process known as glutamate excitotoxicity, leading to neuronal damage.
Colin Moriarty, Natasha Gupta, Debanjan Bhattacharya   +2 more
wiley   +1 more source

Curcumin reduces pain after spinal cord injury in rats by decreasing oxidative stress and increasing GABAA receptor and GAD65 levels. [PDF]

Sci Rep
Hadadi M, Farazi MM, Mehrabani M, Tashakori-Miyanroudi M, Behroozi Z.   +4 more
europepmc   +1 more source

Amyloid-β Impairs Synaptic Inhibition via GABAA Receptor Endocytosis

Journal of Neuroscience, 2015
D. Ulrich
semanticscholar   +1 more source

Astrocytes Mediate Psychostimulant‐Induced Alterations of Spike‐Timing Dependent Synaptic Plasticity

Glia, Volume 73, Issue 5, Page 1051-1067, May 2025.
Main Points Cocaine and amphetamine stimulates astrocytes and downregulates the GLT‐1. The dysfunction in GLT‐1 modify EPSP kinetics and modulate STDP, switching LTP to LTD in psychostimulant‐treated mice. These effects were restored by upregulation of GLT‐1.
Samuel Alberquilla, Carmen Nanclares, Sara Expósito, Grace Gall, Paulo Kofuji, Alfonso Araque, Eduardo D. Martín, Rosario Moratalla   +7 more
wiley   +1 more source

Early developmental changes in GABAA receptor expression in nucleus accumbens medium spiny neurons. [PDF]

Front Neurosci
Wang ZZ, Folorunso OO, Morris K, Berretta S, Engin E.   +4 more
europepmc   +1 more source

Cryo-EM structures reveal native GABA_A receptor assemblies and pharmacology. [PDF]

Nature, 2023
Sun C, Zhu H, Clark S, Gouaux E.
europepmc   +1 more source