Results 121 to 130 of about 759,534 (341)

Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type

Nature Neuroscience, 2017
We describe convergent evidence from transcriptomics, morphology, and physiology for a specialized GABAergic neuron subtype in human cortex. Using unbiased single-nucleus RNA sequencing, we identify ten GABAergic interneuron subtypes with combinatorial ...
Eszter Boldog, Trygve E Bakken, R. Hodge, M. Novotny, B. Aevermann, Judith Baka, Sándor Bordé, J. Close, F. Díez-Fuertes, S. Ding, N. Faragó, Á. Kocsis, Balázs Kovács, Zoe Maltzer, J. McCorrison, Jeremy A. Miller, G. Molnár, G. Oláh, A. Ozsvár, Márton Rózsa, Soraya I. Shehata, Kimberly A. Smith, S. Sunkin, Danny N. Tran, P. Venepally, A. Wall, L. Puskás, P. Barzó, F. Steemers, N. Schork, R. Scheuermann, R. Lasken, E. Lein, G. Tamás   +33 more
semanticscholar   +1 more source

Hominoid‐specific calretinin‐immunopositivity of the optic radiation (geniculocalcarine tract)

The Anatomical Record, EarlyView.
Calretinin‐immunostained coronal section through the primary (V1) and extrastriate (ExSt) cortex of the lar gibbon. Note that the optic radiation (OR) is strongly calretinin‐immunoreactive. This calretinin‐immunopositivity of the OR distinguishes the Hominoidea from other primates in terms of the neurochemistry of the OR.
Nelyane N. M. Santana, Jordan Swiegers, Mads F. Bertelsen, Chet C. Sherwood, José R. L. P. Cavalcanti, Paul R. Manger   +5 more
wiley   +1 more source

Striatal function scrutinized through the PAN-TAN-FSI triumvirate

Frontiers in Cellular Neuroscience
Understanding the information encoded by distinct components of the neuronal circuitry in the striatum represents an avenue for elucidating the role of this subcortical region in adaptive behavior and its dysfunction in pathological conditions.
Paul Apicella, Anne-Caroline Martel, Kevin Marche   +2 more
doaj   +1 more source

Motor alterations induced by chronic 4-aminopyridine infusion in the spinal cord in vivo: role of glutamate and GABA receptors

Frontiers in Neuroscience, 2016
Motor neuron degeneration is the pathological hallmark of motor neuron diseases, a group of neurodegenerative disorders clinically manifested as muscle fasciculations and hyperreflexia, followed by paralysis, respiratory failure and death. Ample evidence
Rafael eLazo-Gómez, Ricardo eTapia
doaj   +1 more source

Dietary Transfer of Zinc Oxide Nanoparticles Induces Locomotive Defects Associated with GABAergic Motor Neuron Damage in Caenorhabditis elegans [PDF]

, 2023
Chun Ming How, Chi‐Wei Huang
openalex   +1 more source

Rubrolides A, D, P, T, U: Total Syntheses and Antibacterial Evaluation of Highly Brominated Marine Natural Products

ChemistryEurope, EarlyView.
Following the Danube Flow. The first total syntheses of highly brominated rubrolides T, U, and U‐analog, together with the efficient and divergent syntheses of rubrolides A, D, and P. The dibrominated key intermediate, obtained via a Suzuki‐Miyaura cross‐coupling reaction, is the centerpiece of the synthesis.
Jasmin Janneschütz, Paul G. Schebek, Alexander Meyer, Celina Haller, Sophia Khom, Wolfgang R. Streit, Ifey Alio, Nina Schützenmeister   +7 more
wiley   +1 more source

Excitatory neuron-prone prion propagation and excitatory neuronal loss in prion-infected mice

Frontiers in Molecular Neuroscience
The accumulation of a disease-specific isoform of prion protein (PrPSc) and histopathological lesions, such as neuronal loss, are unevenly distributed in the brains of humans and animals affected with prion diseases. This distribution varies depending on
Temuulen Erdenebat, Yusuke Komatsu, Nozomi Uwamori, Misaki Tanaka, Takashi Hoshika, Takeshi Yamasaki, Ayano Shimakura, Akio Suzuki, Akio Suzuki, Toyotaka Sato, Toyotaka Sato, Motohiro Horiuchi, Motohiro Horiuchi, Motohiro Horiuchi   +13 more
doaj   +1 more source

A VTA GABAergic Neural Circuit Mediates Visually Evoked Innate Defensive Responses

Neuron, 2018
Innate defensive responses are essential for animal survival and are conserved across species. The ventral tegmental area (VTA) plays important roles in learned appetitive and aversive behaviors, but whether it plays a role in mediating or modulating ...
Zheng Zhou, Xuemei Liu, Shanping Chen, Zhijian Zhang, Yuanming Liu, Q. Montardy, Yongqiang Tang, Pengfei Wei, Nan Liu, Lei Li, Ru Song, Juan Lai, Xiaobin He, Chen Chen, Guoqiang Bi, G. Feng, Fuqiang Xu, Liping Wang   +17 more
semanticscholar   +1 more source

In Vivo Cytoskeletal AMPA Receptor Transport Imaging in C. elegans

Cytoskeleton, EarlyView.
ABSTRACT Long‐distance intracellular transport of ionotropic glutamate receptors (iGluRs) is essential for proper excitatory synaptic function underlying learning and memory. Many neuropsychiatric and neurodegenerative conditions have abnormal iGluR transport and trafficking, leading to an intense interest in the mechanisms and factors regulating these
Michaelis A. K., Hoerndli F. J.
wiley   +1 more source

Synaptic interaction of hippocampal gabaergic neurones

, 1996
Current concepts of hippocampal circuitry assume a large population of excitatory principal neurones whose activity is largely governed by a network of local-circuit GABAergic interneurones. The diversity of hippocampal local-circuit neurones and their synaptic control over principal cell activity was investigated in vitro, in order to define their ...
Cobb, S, Cobb, Stuart
openaire   +1 more source