Integrative cross-species analysis of GABAergic neuron cell types and their functions in Alzheimer’s disease [PDF]
Scientific Reports, 2022 Understanding the phenotypic and functional diversity of cerebral cortical GABAergic neurons requires a comprehensive analysis of key transcriptional signatures and neuronal subtype identity.
Shiyou Wang +8 more
doaj +3 more sources
Transcriptomic and spatial GABAergic neuron subtypes in zona incerta mediate distinct innate behaviors [PDF]
Nature CommunicationsUnderstanding the anatomical connection and behaviors of transcriptomic neuron subtypes is critical to delineating cell type-specific functions in the brain.
Mengyue Zhu +11 more
doaj +3 more sources
Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity [PDF]
Cell, 2017 SUMMARY Understanding the organizational logic of neural circuits requires deciphering the biological basis of neuronal diversity and identity, but there is no consensus on defining a neuron type.
Anirban Paul, Jesse Gillis, Megan Crow
exaly +3 more sources
Endoplasmic Reticulum Stress-Mediated Basolateral Amygdala GABAergic Neuron Injury Is Associated With Stress-Induced Mental Disorders in Rats [PDF]
Frontiers in Cellular Neuroscience, 2019 The amygdala is an important center of fear learning and memory and plays a critical role in regulating stress disorders. Previous studies have shown that changes in the amygdala caused by stress are an important cause of mental disorders including ...
Songjun Wang +7 more
doaj +3 more sources
GABAergic System in Stress: Implications of GABAergic Neuron Subpopulations and the Gut-Vagus-Brain Pathway [PDF]
Neural Plasticity, 2020 Stress can cause a variety of central nervous system disorders, which are critically mediated by the γ-aminobutyric acid (GABA) system in various brain structures.
Xueqin Hou +5 more
doaj +3 more sources
NaV1.1 haploinsufficiency impairs glutamatergic and GABAergic neuron function in the thalamus. [PDF]
Neurobiol Dis, 2022 Thalamocortical network dysfunction contributes to seizures and sleep deficits in Dravet syndrome (DS), an infantile epileptic encephalopathy, but the underlying molecular and cellular mechanisms remain elusive. DS is primarily caused by mutations in the
Studtmann C +4 more
europepmc +2 more sources
CNSC-01. GABAERGIC NEURON-TO-GLIOMA SYNAPSES IN DIFFUSE MIDLINE GLIOMAS [PDF]
Neuro Oncol, 2023 High-grade gliomas include clinically and molecularly distinct subtypes that stratify by anatomical location into diffuse midline gliomas (DMG) such as diffuse intrinsic pontine glioma (DIPG) and hemispheric high-grade gliomas.
Tara Barron +20 more
europepmc +2 more sources
Chromatin remodeller CHD7 is required for GABAergic neuron development by promoting PAQR3 expression. [PDF]
EMBO Rep, 2021 Mutations in the chromatin remodeller‐coding gene CHD7 cause CHARGE syndrome (CS). CS features include moderate to severe neurological and behavioural problems, clinically characterized by intellectual disability, attention‐deficit/hyperactivity disorder
Jamadagni P +8 more
europepmc +2 more sources
GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter. [PDF]
Mol Brain, 2021 GABAergic interneurons play a critical role in tuning neural networks in the central nervous system, and their defects are associated with neuropsychiatric disorders.
Hoshino C +6 more
europepmc +2 more sources
Total Number and Ratio of GABAergic Neuron Types in the Mouse Lateral and Basal Amygdala. [PDF]
J Neurosci, 2021 GABAergic neurons are key circuit elements in cortical networks. Despite growing evidence showing that inhibitory cells play a critical role in the lateral (LA) and basal (BA) amygdala functions, neither the number of GABAergic neurons nor the ratio of ...
Vereczki VK +8 more
europepmc +2 more sources