Results 121 to 130 of about 546,048 (293)

Quantitative comparison of axon growth in non-GABAergic and GABAergic neurons.

, 2016
(A) Box plots of axon lengths of non-GABAergic (red) and GABAergic (blue) neurons on micropatterns (Pattern #3; n = 89 cells). The boxes indicate the interquartile range of the data, the range between the 75th percentile and the 25th percentile.
Takatoshi Kushida (2938257), Sho Kono (2938260), Hideaki Yamamoto (331180), Ayumi Hirano-Iwata (1961665), Takashi Tanii (843278), Michio Niwano (1961668)   +5 more
core   +1 more source

Generation of pure GABAergic neurons by transcription factor programming [PDF]

, 2017
Transient transcription factor expression rapidly induces a homogenous population of mature GABAergic neurons from human pluripotent stem cells, aiding the study of inhibitory neuron function and ...
Wernig, Marius, Ng, Yi-Han, Mall, Moritz, Buylla, Arturo Alvarez, Marro, Samuele, Ng, Yi Han, Yang, Nan, Moritz Mall, Quetzal Flores, Tang, Yunshuo, Cheen Euong Ang, Nan Yang, Daniel Haag, Soham Chanda, Mavis Li, Marius Wernig, Yi-Han Ng, Flores, Quetzal, Südhof, Thomas C, Ang, Cheen Euong, Wapinski, Orly, Ahlenius, Henrik, Rubenstein, John L, Orly Wapinski, Janas, Justyna A., Janas, Justyna A, Chang, Howard Y, Südhof, Thomas C., Arturo Alvarez Buylla, Samuele Marro, Chang, Howard Y., John L Rubenstein, Thomas C Südhof, Yunshuo Tang, Henrik Ahlenius, Howard Y Chang, Chanda, Soham, Justyna A Janas, Haag, Daniel, Rubenstein, John L., Li, Mavis, Haag, Daniel,, Chanda, Soham,, Mall, Moritz,, Marro, Samuele,, Lund University., Tang, Yunshuo,, Janas, Justyna A.,, Ng, Yi Han,, Flores, Quetzal,, Yang, Nan,, Ahlenius, Henrik,, Ang, Cheen Euong,   +52 more
core   +1 more source

T Cell‐Mediated Targeting of Interneurons in Mice Shapes Hippocampal Remodeling and Epilepsy

Annals of Neurology, EarlyView.
Objective Autoimmune encephalitis (AE) is associated with autoantibodies targeting distinct neuronal populations. In AE, antibodies against glutamate decarboxylase 65 (GAD65), expressed in GABAergic interneurons, are frequently detected. In GAD65‐AE, hippocampal biopsies often show infiltrates of CD8+ cytotoxic T cells (CTLs), suggesting a prominent T ...
Daniel S. Galvis‐Montes, Lukas Henning, Karen M. J. van Loo, Rainer Surges, Susanne Schoch, Albert J. Becker, Julika Pitsch   +6 more
wiley   +1 more source

GABAergic inhibition shapes interictal dynamics in awake epileptic mice

, 2015
International audienceEpilepsy is characterized by recurrent seizures and brief, synchronous bursts called interictal spikes that are present in-between seizures and observed as transient events in EEG signals.
Bartolomei, Fabrice, Villette, Vincent, Tressard, Thomas, Cossart, Rosa, Muldoon, Sarah, Feldt, Reichinnek, Susanne, Malvache, Arnaud   +6 more
core   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Linking actions to outcomes : the role of the posterior pedunculopontine tegmental nucleus in instrumental learning [PDF]

, 2012
Located in the mesopontine tegmentum, the pedunculopontine tegmental nucleus (PPTg) is comprised principally of glutamatergic, cholinergic and GABAergic neurons.
MacLaren, Duncan A. A.
core   +1 more source

Moving beyond neurophobia to cultivate the neuroquisitive learner

Anatomical Sciences Education, EarlyView.
Abstract “Neurophobia,” a pervasive fear of the neurological sciences, poses a significant barrier in medical education, affecting learners and physicians worldwide. Its consequences are far‐reaching, contributing to a limited neurology workforce and diminished confidence among non‐specialists in managing neurological conditions.
Joanna R. Appel, Kirsten A. Porter‐Stransky   +1 more
wiley   +1 more source

Dose‐related propofol resistance in COVID‐19 patients: Altered drug plasma levels, mechanistic insights from neuronal‐derived extracellular vesicles and miRNA analysis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Critical care for COVID‐19 patients presents unique challenges, particularly in sedation management. Patients demonstrate notable dose‐related resistance to propofol, potentially due to complex pharmacokinetic alterations. Emerging evidence suggests that plasma extracellular vesicle‐associated miRNA represents valuable predictive ...
Debora Curci, Carlotta Bidoli, Marco Gerdol, Charisse Winston, Robert A. Rissman, Giuliana Decorti, Antonella Fabretto, Andrea Taddio, Gabriele Stocco, Erik Roman‐Pognuz, Marianna Lucafò   +10 more
wiley   +1 more source

Simultaneous release of glutamate and acetylcholine from single magnocellular "cholinergic" basal forebrain neurons [PDF]

, 2006
Basal forebrain (BF) neurons provide the principal cholinergic drive to the hippocampus and cortex. Their degeneration is associated with the cognitive defects of Alzheimer's disease. Immunohistochemical studies suggest that some of these neurons contain
Allen, TGJ, Abogadie, FC, Brown, DA
core  

In Vivo Cytoskeletal AMPA Receptor Transport Imaging in C. elegans

Cytoskeleton, EarlyView.
ABSTRACT Long‐distance intracellular transport of ionotropic glutamate receptors (iGluRs) is essential for proper excitatory synaptic function underlying learning and memory. Many neuropsychiatric and neurodegenerative conditions have abnormal iGluR transport and trafficking, leading to an intense interest in the mechanisms and factors regulating these
Michaelis A. K., Hoerndli F. J.
wiley   +1 more source