Results 181 to 190 of about 184,302 (307)

Identification and validation of glycosaminoglycan metabolism-associated immune biomarkers in patients with ischemic stroke based on weighted gene co-expression network analysis and machine learning. [PDF]

Front Neurol
Xie B, Ou Y, Liu Q, Li Y.
europepmc   +1 more source

Introduction of a Double‐Headed Nucleotide Into G‐Quadruplex DNA: Position‐Dependent Stabilization and Structural Insights

Chemistry – A European Journal, EarlyView.
A double‐headed bis‐guanine (G) nucleotide (GG) was evaluated as a noncanonical building block in G‐quadruplexes (G4s). Biophysical and computational analyses reveal that GG can directly participate in G‐tetrads and strongly stabilize G4s in a position‐ and topology‐dependent manner. These findings establish design rules for using GG to engineer highly
Krista Urup, Peter Reinholdt, Kasper Munch Beck, Michael Petersen, Jean‐Louis Mergny, Poul Nielsen   +5 more
wiley   +1 more source

Proteoglycans as Regulators of Receptor Trafficking and Spatial Signaling in Cancer. [PDF]

Cancers (Basel)
Berdiaki A, Konstantaraki M, Ajlan Z, Marmara M, Tsatsakis A, Tzanakakis G, Nikitovic D.   +6 more
europepmc   +1 more source

Multivalent RNA‐Cleaving Agents on a Cubic Octameric Silsesquioxane Core

Chemistry – A European Journal, EarlyView.
RNA‐cleaving agents on a cubic octameric silsesquioxane core were synthesized and characterized. Several catalytic systems of these structures were screened using hexaribonucleotide models. The best systems were then further used to study their catalytic efficiency in cleaving a HER2 mRNA model sequence. The induced cleavage sites were also determined.
Hanni Haapsaari, Iris Tuomi, Pasi Virta
wiley   +1 more source

Pre-Cambrian origin of <i>envelope</i>-carrying retrotransposons in metazoans. [PDF]

Elife
Chary S, Hayashi R.
europepmc   +1 more source

Demulsifying agent simplified model for offshore oil wells

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract This article addresses key challenges in offshore petroleum production caused by multiphase flow instabilities, such as slug flow and emulsion formation. Traditionally, severe slugging is mitigated by increasing wellhead backpressure through partial choke valve closure. In this context, a simplified dynamic model—the fast offshore wells model (
Fernanda Bernardi de Souza, Bárbara Isabel Santarossa, Ricardo França Rodrigues, Fabio Diehl, Marcelo Farenzena, Jorge Otávio Trierweiler   +5 more
wiley   +1 more source

Proximity labeling puts ZFP36L1 as central hub for posttranscriptional regulation networks in T cells. [PDF]

Life Sci Alliance
Jurgens AP, Popović B, van Alphen FP, Steinmetz M, Wardak L, Bradarić A, Engels S, van der Zwaan C, van den Biggelaar M, Hoogendijk AJ, Béthune J, Wolkers MC.   +11 more
europepmc   +1 more source

GAGs [PDF]

, 2019
openaire   +1 more source

Occurrence of severe slugging in oil production lines and mitigation methods: A numerical simulation approach using ALFAsim®

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract Severe slugging represents a major challenge in offshore production systems, potentially compromising operational stability and the integrity of installations. Although established simulators such as OLGA® are widely used for its analysis, there is a gap in the literature regarding the application of the one‐dimensional simulator ALFAsim® for ...
Wayne Gabriel Nóbrega Firme, Tony Herbert Freire de Andrade, Phillipe Augusto Sales, Ricardo Soares Gomez, João Alves de Lima   +4 more
wiley   +1 more source

Engineering Allogeneic FE002-Cart Chondroprogenitor Spheroids for Large Knee Chondral Defects: Investigating Microenvironmental Cues for Functional Control, GMP Formulation, and Logistical Viability. [PDF]

Pharmaceutics
Applegate LA, Hadjab F, Jaccoud S, Porcello A, Philippe V, Hirt-Burri N, Scaletta C, Jolles BM, Pioletti DP, Martin R, Laurent AE.   +10 more
europepmc   +1 more source