Results 71 to 80 of about 339,221 (330)

Distinct Contributions of Different Domains within the HIV-1 Gag Polyprotein to Specific and Nonspecific Interactions with RNA

open access: yesViruses, 2020
Viral genomic RNA is packaged into virions with high specificity and selectivity. However, in vitro the Gag specificity towards viral RNA is obscured when measured in buffers containing physiological salt. Interestingly, when the binding is challenged by
Tomas Kroupa   +2 more
doaj   +1 more source

The deregulation of New Zealand agriculture : market intervention (1964-84) and free market readjustment (1984-90) [PDF]

open access: yes, 1991
The impacts of deregulation on New Zealand's agricultural sector are examined. Economic liberalization of all sectors of economic activity is the hallmark of current economic policy designs in New Zealand.
Frengley, GAG, Johnston, WE
core  

Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3. [PDF]

open access: yes, 2016
CC chemokine ligand 5 (CCL5) and CCL3 are critical for immune surveillance and inflammation. Consequently, they are linked to the pathogenesis of many inflammatory conditions and are therapeutic targets.
Banerjee, S   +7 more
core   +1 more source

CRISPR/Cas9‐Assisted Microrobots for Fast and Ultrasensitive “On‐The‐Fly” Next‐Generation DNA Detection

open access: yesAdvanced Functional Materials, EarlyView.
This work presents self‐propelled CRISPR/Cas9‐functionalized Au–MRs for rapid, amplification‐free, “on‐the‐fly” DNA detection. By harnessing motion‐assisted signal recovery, the platform achieved the limit of detection in low fM DNA concentrations, enabling detection across a wide dynamic range within only 5 min, which is significantly faster than any ...
Jyoti   +3 more
wiley   +1 more source

Moloney murine leukemia virus glyco-gag facilitates xenotropic murine leukemia virus-related virus replication through human APOBEC3-independent mechanisms

open access: yesRetrovirology, 2012
Background One of the unique features of gammaretroviruses is that they contain an additional extended form of Gag, glyco-gag, which initiates in the leader sequence.
Nitta Takayuki   +5 more
doaj   +1 more source

Analysis of the initiating events in HIV-1 particle assembly and genome packaging. [PDF]

open access: yesPLoS Pathogens, 2010
HIV-1 Gag drives a number of events during the genesis of virions and is the only viral protein required for the assembly of virus-like particles in vitro and in cells.
Sebla B Kutluay, Paul D Bieniasz
doaj   +1 more source

HIV-1 Gag-specific immunity induced by a lentivector-based vaccine directed to dendritic cells [PDF]

open access: yes, 2009
Lentivectors (LVs) have attracted considerable interest for their potential as a vaccine delivery vehicle. In this study, we evaluate in mice a dendritic cell (DC)-directed LV system encoding the Gag protein of human immunodeficiency virus (HIV) (LV-Gag)
Baltimore, David   +5 more
core   +2 more sources

Wafer‐Scale Integration of α‐quartz Thin Films toward Super High Frequency Piezoelectric bioNEMS for Chikungunya Virus Detection

open access: yesAdvanced Functional Materials, EarlyView.
Epitaxial piezoelectric α‐quartz/Si BioNEMS sensors, made using soft chemistry, effectively detect the Chikungunya virus. They have a mass sensitivity of 205 pg Hz−1 in liquid and can detect the virus at a limit of 9 ng mL−1. This development enables high‐frequency mass devices for point‐of‐care testing in healthcare and other electronic applications ...
Raissa Rathar   +12 more
wiley   +1 more source

Molecular mechanisms by which HERV-K Gag interferes with HIV-1 Gag assembly and particle infectivity

open access: yesRetrovirology, 2017
Background Human endogenous retroviruses (HERVs), the remnants of ancient retroviral infections, constitute approximately 8% of human genomic DNA. Since HERV-K Gag expression is induced by HIV-1 Tat in T cells, induced HERV-K proteins could affect HIV-1 ...
Kazuaki Monde   +6 more
doaj   +1 more source

The Ty1 Retrotransposon Restriction Factor p22 Targets Gag. [PDF]

open access: yesPLoS Genetics, 2015
A novel form of copy number control (CNC) helps maintain a low number of Ty1 retrovirus-like transposons in the Saccharomyces genome. Ty1 produces an alternative transcript that encodes p22, a trans-dominant negative inhibitor of Ty1 retrotransposition ...
Jessica M Tucker   +4 more
doaj   +1 more source

Home - About - Disclaimer - Privacy